DNA double-strand break repair within heterochromatic regions

DNA DSBs (double-strand breaks) represent a critical lesion for a cell, with misrepair being potentially as harmful as lack of repair. In mammalian cells, DSBs are predominantly repaired by non-homologous end-joining or homologous recombination. The kinetics of repair of DSBs can differ widely, and...

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Bibliographic Details
Published in:	Biochemical Society transactions Vol. 40; no. 1; p. 173
Main Authors:	Murray, Johanne M, Stiff, Tom, Jeggo, Penny A
Format:	Journal Article
Language:	English
Published:	England 01.02.2012
Subjects:	Animals Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins - metabolism Chromatin Assembly and Disassembly DNA Breaks, Double-Stranded DNA Helicases - metabolism DNA Repair DNA-Binding Proteins - metabolism Euchromatin - metabolism Heterochromatin - metabolism Histones - metabolism Humans Mi-2 Nucleosome Remodeling and Deacetylase Complex Phosphorylation Protein-Serine-Threonine Kinases - metabolism Repressor Proteins - metabolism Tripartite Motif-Containing Protein 28 Tumor Suppressor Proteins - metabolism
ISSN:	1470-8752, 1470-8752
Online Access:	Get more information
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