Blood-derived amyloid-β protein induces Alzheimer's disease pathologies
The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue itself. However, Aβ is generated in both brain and peripheral tissues. Whether circulating Aβ contributes to br...
Saved in:
| Published in: | Molecular psychiatry Vol. 23; no. 9; pp. 1948 - 1956 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Nature Publishing Group
01.09.2018
|
| Subjects: | |
| ISSN: | 1359-4184, 1476-5578, 1476-5578 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue itself. However, Aβ is generated in both brain and peripheral tissues. Whether circulating Aβ contributes to brain AD-type pathologies remains largely unknown. In this study, using a model of parabiosis between APPswe/PS1dE9 transgenic AD mice and their wild-type littermates, we observed that the human Aβ originated from transgenic AD model mice entered the circulation and accumulated in the brains of wild-type mice, and formed cerebral amyloid angiopathy and Aβ plaques after a 12-month period of parabiosis. AD-type pathologies related to the Aβ accumulation including tau hyperphosphorylation, neurodegeneration, neuroinflammation and microhemorrhage were found in the brains of the parabiotic wild-type mice. More importantly, hippocampal CA1 long-term potentiation was markedly impaired in parabiotic wild-type mice. To the best of our knowledge, our study is the first to reveal that blood-derived Aβ can enter the brain, form the Aβ-related pathologies and induce functional deficits of neurons. Our study provides novel insight into AD pathogenesis and provides evidence that supports the development of therapies for AD by targeting Aβ metabolism in both the brain and the periphery. |
|---|---|
| AbstractList | The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue itself. However, Aβ is generated in both brain and peripheral tissues. Whether circulating Aβ contributes to brain AD-type pathologies remains largely unknown. In this study, using a model of parabiosis between APPswe/PS1dE9 transgenic AD mice and their wild-type littermates, we observed that the human Aβ originated from transgenic AD model mice entered the circulation and accumulated in the brains of wild-type mice, and formed cerebral amyloid angiopathy and Aβ plaques after a 12-month period of parabiosis. AD-type pathologies related to the Aβ accumulation including tau hyperphosphorylation, neurodegeneration, neuroinflammation and microhemorrhage were found in the brains of the parabiotic wild-type mice. More importantly, hippocampal CA1 long-term potentiation was markedly impaired in parabiotic wild-type mice. To the best of our knowledge, our study is the first to reveal that blood-derived Aβ can enter the brain, form the Aβ-related pathologies and induce functional deficits of neurons. Our study provides novel insight into AD pathogenesis and provides evidence that supports the development of therapies for AD by targeting Aβ metabolism in both the brain and the periphery. The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue itself. However, Aβ is generated in both brain and peripheral tissues. Whether circulating Aβ contributes to brain AD-type pathologies remains largely unknown. In this study, using a model of parabiosis between APPswe/PS1dE9 transgenic AD mice and their wild-type littermates, we observed that the human Aβ originated from transgenic AD model mice entered the circulation and accumulated in the brains of wild-type mice, and formed cerebral amyloid angiopathy and Aβ plaques after a 12-month period of parabiosis. AD-type pathologies related to the Aβ accumulation including tau hyperphosphorylation, neurodegeneration, neuroinflammation and microhemorrhage were found in the brains of the parabiotic wild-type mice. More importantly, hippocampal CA1 long-term potentiation was markedly impaired in parabiotic wild-type mice. To the best of our knowledge, our study is the first to reveal that blood-derived Aβ can enter the brain, form the Aβ-related pathologies and induce functional deficits of neurons. Our study provides novel insight into AD pathogenesis and provides evidence that supports the development of therapies for AD by targeting Aβ metabolism in both the brain and the periphery.The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue itself. However, Aβ is generated in both brain and peripheral tissues. Whether circulating Aβ contributes to brain AD-type pathologies remains largely unknown. In this study, using a model of parabiosis between APPswe/PS1dE9 transgenic AD mice and their wild-type littermates, we observed that the human Aβ originated from transgenic AD model mice entered the circulation and accumulated in the brains of wild-type mice, and formed cerebral amyloid angiopathy and Aβ plaques after a 12-month period of parabiosis. AD-type pathologies related to the Aβ accumulation including tau hyperphosphorylation, neurodegeneration, neuroinflammation and microhemorrhage were found in the brains of the parabiotic wild-type mice. More importantly, hippocampal CA1 long-term potentiation was markedly impaired in parabiotic wild-type mice. To the best of our knowledge, our study is the first to reveal that blood-derived Aβ can enter the brain, form the Aβ-related pathologies and induce functional deficits of neurons. Our study provides novel insight into AD pathogenesis and provides evidence that supports the development of therapies for AD by targeting Aβ metabolism in both the brain and the periphery. |
| Author | Liu, Y-H Song, W Xiang, Y Chen, S-H Dong, Z-F Zhou, H-D Shen, L-L Zeng, F Chen, X-W Yao, X-Q Jin, W-S Sun, H-L Bu, X-L Shan, Y-C Wang, J Liu, J-H Huang, Z-L Zhuang, Z-Q Giunta, B Tan, J Zhou, X-F Zhang, K Wang, Y-J |
| Author_xml | – sequence: 1 givenname: X-L surname: Bu fullname: Bu, X-L organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 2 givenname: Y surname: Xiang fullname: Xiang, Y organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 3 givenname: W-S surname: Jin fullname: Jin, W-S organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 4 givenname: J surname: Wang fullname: Wang, J organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 5 givenname: L-L surname: Shen fullname: Shen, L-L organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 6 givenname: Z-L surname: Huang fullname: Huang, Z-L organization: Ministry of Education Key Laboratory of Child Development and Disorders and Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China – sequence: 7 givenname: K surname: Zhang fullname: Zhang, K organization: Brain Research Center and State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China – sequence: 8 givenname: Y-H surname: Liu fullname: Liu, Y-H organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 9 givenname: F surname: Zeng fullname: Zeng, F organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 10 givenname: J-H surname: Liu fullname: Liu, J-H organization: University of Chinese Academy of Sciences, Beijing, China – sequence: 11 givenname: H-L surname: Sun fullname: Sun, H-L organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 12 givenname: Z-Q surname: Zhuang fullname: Zhuang, Z-Q organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 13 givenname: S-H surname: Chen fullname: Chen, S-H organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 14 givenname: X-Q surname: Yao fullname: Yao, X-Q organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 15 givenname: B surname: Giunta fullname: Giunta, B organization: Neuroimmunology Laboratory, Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, FL, USA – sequence: 16 givenname: Y-C surname: Shan fullname: Shan, Y-C organization: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China – sequence: 17 givenname: J surname: Tan fullname: Tan, J organization: Rashid Laboratory for Developmental Neurobiology, Silver Child Development Center, Department of Psychiatry and Behavioral Neurosciences, Morsani College of Medicine, University of South Florida, Tampa, FL, USA – sequence: 18 givenname: X-W surname: Chen fullname: Chen, X-W organization: Brain Research Center and State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China – sequence: 19 givenname: Z-F surname: Dong fullname: Dong, Z-F organization: Ministry of Education Key Laboratory of Child Development and Disorders and Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China – sequence: 20 givenname: H-D surname: Zhou fullname: Zhou, H-D organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China – sequence: 21 givenname: X-F surname: Zhou fullname: Zhou, X-F organization: School of Pharmacy and Medical Sciences and Sansom Institute, University of South Australia, Adelaide, SA, Australia – sequence: 22 givenname: W surname: Song fullname: Song, W email: weihong@mail.ubc.ca organization: Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada. weihong@mail.ubc.ca – sequence: 23 givenname: Y-J surname: Wang fullname: Wang, Y-J email: yanjiang_wang@tmmu.edu.cn organization: Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. yanjiang_wang@tmmu.edu.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29086767$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkMtKw0AUhgep2Iuu3EvAhW5S5z6TZS1qhYIbXYfJzKmdkmRiJhHqY_kgPpMR68bN-Q_8H4ePM0WjOtSA0DnBc4KZvqmaOcVEDYMfoQnhSqZCKD0adiaylBPNx2ga4w7jn1KcoDHNsJZKqgla3ZYhuNRB69_BJabal8G79OszadrQga8TX7veQkwW5ccWfAXtVUycj2AiJI3ptqEMrx7iKTremDLC2SFn6OX-7nm5StdPD4_LxTq1TPAutS6zmG2swEKBVAYzuyHAOC2kcdoqqxjRBS6kwIxwSzixWBYgLKeYCkPYDF3_3h383nqIXV75aKEsTQ2hjznJhBZMSsEG9PIfugt9Ww92OSWMUqGE5gN1caD6ogKXN62vTLvP_37EvgGDkGky |
| CitedBy_id | crossref_primary_10_1007_s00401_018_1939_3 crossref_primary_10_1016_j_biomaterials_2025_123146 crossref_primary_10_1016_j_biochi_2020_04_011 crossref_primary_10_1038_s41582_020_0333_7 crossref_primary_10_1038_s41467_023_37316_z crossref_primary_10_1038_nrneurol_2017_164 crossref_primary_10_1016_j_biosystems_2020_104256 crossref_primary_10_3233_JAD_220122 crossref_primary_10_1134_S0026893319060104 crossref_primary_10_1186_s12974_021_02086_2 crossref_primary_10_3389_fnmol_2024_1362581 crossref_primary_10_1111_jnc_15096 crossref_primary_10_3389_fnmol_2022_927530 crossref_primary_10_3389_fnagi_2019_00236 crossref_primary_10_3233_JAD_190298 crossref_primary_10_3390_biom11111652 crossref_primary_10_3390_coatings13061122 crossref_primary_10_1007_s12264_023_01175_x crossref_primary_10_3390_biom11091287 crossref_primary_10_3390_pharmaceutics16070948 crossref_primary_10_2174_0109298673269288231123095215 crossref_primary_10_1007_s11357_020_00164_6 crossref_primary_10_3390_ijms24021088 crossref_primary_10_3389_fmicb_2024_1358179 crossref_primary_10_1093_jalm_jfaa235 crossref_primary_10_1186_s12951_024_02428_1 crossref_primary_10_1038_s41593_018_0332_9 crossref_primary_10_1016_S1474_4422_20_30238_6 crossref_primary_10_3389_fnagi_2020_557384 crossref_primary_10_1016_j_envres_2025_121898 crossref_primary_10_3389_fnagi_2021_706765 crossref_primary_10_1038_s41380_021_01350_4 crossref_primary_10_1007_s11357_023_00855_w crossref_primary_10_1111_jfbc_14183 crossref_primary_10_1016_j_arr_2021_101451 crossref_primary_10_4103_1673_5374_391305 crossref_primary_10_1007_s00604_020_04650_8 crossref_primary_10_1111_ejn_14390 crossref_primary_10_1155_2019_5030475 crossref_primary_10_3390_cells11152285 crossref_primary_10_1016_j_cej_2020_126055 crossref_primary_10_1177_13872877251378778 crossref_primary_10_1186_s40478_018_0511_7 crossref_primary_10_1055_s_0041_1733960 crossref_primary_10_1007_s00109_019_01810_z crossref_primary_10_1007_s00415_024_12337_w crossref_primary_10_1080_1061186X_2018_1491979 crossref_primary_10_1007_s00401_018_1891_2 crossref_primary_10_3390_cimb46070384 crossref_primary_10_3390_ijms19061705 crossref_primary_10_1134_S1022795422060126 crossref_primary_10_3389_fimmu_2020_00747 crossref_primary_10_1016_j_nbd_2024_106427 crossref_primary_10_1111_acel_70094 crossref_primary_10_15252_embr_202154405 crossref_primary_10_1038_s41380_018_0225_z crossref_primary_10_1186_s12974_023_03003_5 crossref_primary_10_3389_fnins_2020_00658 crossref_primary_10_3233_JAD_220415 crossref_primary_10_3389_fimmu_2020_571083 crossref_primary_10_1002_agt2_70078 crossref_primary_10_1007_s12975_021_00921_5 crossref_primary_10_1038_s41398_024_02836_9 crossref_primary_10_1007_s12264_018_0249_z crossref_primary_10_1016_j_ygcen_2022_114126 crossref_primary_10_3390_ijms24010183 crossref_primary_10_1007_s12640_019_00035_9 crossref_primary_10_3390_jdb6010001 crossref_primary_10_4103_NRR_NRR_D_24_01440 crossref_primary_10_3389_fnagi_2020_511562 crossref_primary_10_3390_diagnostics12071522 crossref_primary_10_1177_1721727X221095383 crossref_primary_10_1186_s13024_022_00559_3 crossref_primary_10_3389_fnmol_2018_00302 crossref_primary_10_1038_s41598_025_14559_y crossref_primary_10_1038_s41598_021_94048_0 crossref_primary_10_1080_15548627_2019_1596488 crossref_primary_10_1007_s12264_019_00382_9 crossref_primary_10_1186_s13195_022_01104_6 crossref_primary_10_1002_brb3_70501 crossref_primary_10_3389_fnagi_2020_619866 crossref_primary_10_3389_fncel_2018_00307 crossref_primary_10_1016_j_nbd_2024_106485 crossref_primary_10_1016_j_tmrv_2024_150858 crossref_primary_10_1111_jre_13224 crossref_primary_10_1016_j_mad_2022_111725 crossref_primary_10_1007_s12035_023_03420_w crossref_primary_10_3233_JAD_180176 crossref_primary_10_3389_fnagi_2019_00279 crossref_primary_10_1002_trc2_12004 crossref_primary_10_1016_j_nano_2019_02_004 crossref_primary_10_1002_1873_3468_14549 crossref_primary_10_1007_s12264_019_00394_5 crossref_primary_10_3390_molecules25071659 crossref_primary_10_1002_adma_202006357 crossref_primary_10_1002_cbic_202400912 crossref_primary_10_1186_s13195_022_00964_2 crossref_primary_10_1016_j_neuroscience_2025_06_018 crossref_primary_10_1186_s12920_020_0689_y crossref_primary_10_1136_jnnp_2022_328792 crossref_primary_10_3390_ijms24065383 crossref_primary_10_1186_s13195_025_01840_5 crossref_primary_10_3389_fnins_2018_00518 crossref_primary_10_1182_blood_2022015970 crossref_primary_10_1186_s40478_020_01087_1 crossref_primary_10_1002_dad2_12581 crossref_primary_10_1038_s41380_022_01679_4 crossref_primary_10_3390_biomedicines11051383 crossref_primary_10_3389_fnins_2021_654785 crossref_primary_10_1016_j_exger_2021_111274 crossref_primary_10_3390_biom13040648 crossref_primary_10_1177_26331055221123072 crossref_primary_10_1186_s40035_024_00434_9 crossref_primary_10_1186_s12944_024_02398_1 crossref_primary_10_1186_s12979_023_00366_4 crossref_primary_10_3389_fnins_2022_980658 crossref_primary_10_3390_cells11213442 crossref_primary_10_1515_revneuro_2020_0122 crossref_primary_10_1186_s43088_023_00407_3 crossref_primary_10_1039_D2FO00815G crossref_primary_10_1016_j_arr_2021_101420 crossref_primary_10_3390_molecules27030735 crossref_primary_10_2147_NDT_S374722 crossref_primary_10_1038_s41598_021_02632_1 crossref_primary_10_3233_JAD_190476 crossref_primary_10_1080_14787210_2020_1792292 crossref_primary_10_1038_s41576_018_0011_4 crossref_primary_10_3389_fnagi_2023_1170663 crossref_primary_10_3389_fpsyt_2019_00571 crossref_primary_10_1093_brain_awac013 crossref_primary_10_1038_s41392_023_01484_7 crossref_primary_10_1007_s11357_025_01657_y crossref_primary_10_1177_13872877241299832 crossref_primary_10_1016_j_preteyeres_2020_100899 crossref_primary_10_1002_ana_26935 crossref_primary_10_3389_fnagi_2018_00085 crossref_primary_10_3390_healthcare13050452 crossref_primary_10_1111_ejn_70142 crossref_primary_10_1007_s12264_019_00456_8 crossref_primary_10_3233_JAD_200104 crossref_primary_10_3389_fendo_2023_1127481 crossref_primary_10_1007_s12035_022_02863_x crossref_primary_10_1016_j_jns_2020_116974 crossref_primary_10_1371_journal_pone_0328470 crossref_primary_10_1111_acel_70205 crossref_primary_10_1155_2018_7302045 crossref_primary_10_3389_fncel_2021_680126 |
| ContentType | Journal Article |
| Copyright | Copyright Nature Publishing Group Sep 2018 |
| Copyright_xml | – notice: Copyright Nature Publishing Group Sep 2018 |
| DBID | CGR CUY CVF ECM EIF NPM 3V. 7TK 7X7 7XB 88E 88G 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2M M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 |
| DOI | 10.1038/mp.2017.204 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Psychology Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China One Psychology ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic ProQuest One Psychology |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1476-5578 |
| EndPage | 1956 |
| ExternalDocumentID | 29086767 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: CIHR grantid: TAD-117948 |
| GroupedDBID | --- -Q- 0R~ 123 29M 2WC 36B 39C 4.4 406 53G 70F 7X7 88E 8AO 8FI 8FJ 8R4 8R5 AACDK AANZL AASML AATNV AAYZH ABAKF ABAWZ ABBRH ABDBE ABDBF ABFSG ABIVO ABJNI ABLJU ABRTQ ABUWG ABZZP ACAOD ACGFS ACKTT ACPRK ACRQY ACSTC ACUHS ACZOJ ADBBV AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AEZWR AFBBN AFDZB AFHIU AFKRA AFRAH AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AHWEU AIGIU AILAN AIXLP AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF ATHPR AXYYD AYFIA AZQEC B0M BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CAG CCPQU CGR COF CS3 CUY CVF DIK DNIVK DPUIP DU5 DWQXO E3Z EAD EAP EBC EBD EBLON EBS ECM EE. EIF EIOEI EJD EMB EMK EMOBN EPL EPS ESX F5P FDQFY FEDTE FERAY FIGPU FIZPM FSGXE FYUFA GNUQQ HCIFZ HMCUK HVGLF HZ~ IAO IHR INH INR IPY ITC IWAJR JSO JZLTJ KQ8 M1P M2M M7P NPM NQJWS O9- OK1 OVD P2P PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PSYQQ Q2X RNS RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TEORI TR2 TSG TUS UKHRP ~8M 3V. 7TK 7XB 8FE 8FH 8FK K9. LK8 PKEHL PQEST PQUKI PRINS Q9U 7X8 |
| ID | FETCH-LOGICAL-c354t-cd9c03fc5057e67a03cf1e342b6ad8c7c7318b0b650314c141c06be5c42025a13 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 155 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000450892900008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1359-4184 1476-5578 |
| IngestDate | Sun Nov 09 11:52:08 EST 2025 Thu Nov 06 13:48:43 EST 2025 Mon Jul 21 06:01:58 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c354t-cd9c03fc5057e67a03cf1e342b6ad8c7c7318b0b650314c141c06be5c42025a13 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 29086767 |
| PQID | 2132257584 |
| PQPubID | 44096 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_1958536653 proquest_journals_2132257584 pubmed_primary_29086767 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-09-01 |
| PublicationDateYYYYMMDD | 2018-09-01 |
| PublicationDate_xml | – month: 09 year: 2018 text: 2018-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: New York |
| PublicationTitle | Molecular psychiatry |
| PublicationTitleAlternate | Mol Psychiatry |
| PublicationYear | 2018 |
| Publisher | Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group |
| References | 29123251 - Nat Rev Neurol. 2018 Jan;14(1):4 |
| References_xml | – reference: 29123251 - Nat Rev Neurol. 2018 Jan;14(1):4 |
| SSID | ssj0014765 |
| Score | 2.6206803 |
| Snippet | The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). It is believed that Aβ deposited in the brain... The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD). It is believed that Aβ deposited in the brain... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1948 |
| SubjectTerms | Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - blood Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - physiology Amyloid beta-Protein Precursor - metabolism Animals Blood Brain Brain - metabolism Brain - pathology Cerebral amyloid angiopathy Cerebral Amyloid Angiopathy - metabolism Cerebral blood flow Disease Models, Animal Female Hippocampus Hippocampus - metabolism Inflammation Long-term potentiation Male Mice Mice, Inbred C57BL Mice, Transgenic Neurodegeneration Neurons - metabolism Parabiosis Parabiosis - methods Pathogenesis Phosphorylation Plaque, Amyloid - etiology Plaque, Amyloid - metabolism Presenilin-1 - metabolism Proteins Rodents Senile plaques Tau protein Transgenic mice |
| Title | Blood-derived amyloid-β protein induces Alzheimer's disease pathologies |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29086767 https://www.proquest.com/docview/2132257584 https://www.proquest.com/docview/1958536653 |
| Volume | 23 |
| WOSCitedRecordID | wos000450892900008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NSsNAEB5sVfDi_0_9KRG8hia7m2xykiqKiC1FVHoL6e4GAzatTVvQk6_ha_ggPoRP4uwmrSe9eBkIgSXs_OT7dmZnAE48GSacMWH7imiCEgsbUbWyqZMw6ScxKe5xP9zwdjvodsNOeeCWl2WVs5hoArUcCH1G3iCaNiG2CNjp8NnWU6N0drUcoVGBRd0lgZjSvc48i8C4GSXpUk9nOwNW3s9zaNDo616VLkfBfseW5h9zufbfr1uH1RJdWs3CHDZgQWWbsFzMm3zZguszU6Yu0eqmSlpxH9l6Ku3PD8u0a0gzCxk66jq3mk-vjyrtq9HX23tulVkcS48vNsFS5dtwf3lxd35ll8MUbEE9NraFDIVDE6EJifJ57FCRuIoy0vNjGQguOHp3z-khYqMuEy5zheP3lCcYQVgUu3QHqtkgU3tgEUSJVLCQe4lkKnFCzYPQ96nvSYwXqgaHs02KSo_Io58dqsHx_DXask5QxJkaTPJIN77BVXyP1mC3UEQ0LJpuRCRE8sV9vv_34gewgnoNiiqwQ6iORxN1BEtiOk7zUR0qvMuNDOqweHbR7tziU4u06sZwULY7rW_hwcjt |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V25TsQwEB1xChruYzmNBGVEYjtxUiDEKY5lRQGILmRtR0Ris7BZQEvFb_ATFHwIH8GXME6yUEFHQZMm0kjOvBm_yVwAq64KYsG5tDxNTYASSQtZtbaYHXPlxREt-rgvqqJW8y8vg9MeeO32wpiyyq5PzB21akrzj3ydmrAJuYXPN2_vLLM1ymRXuys0Clgc684jhmzZxuEu6neN0v29s50Dq9wqYEnm8rYlVSBtFkvDzLUnIpvJ2NGM07oXKV8KKRDmdbuO1IU5XDrckbZX167kFPlB5DCU2wv93LSMmlJBevKVteAiX13pMNdkV31e9gPazF9vmNmYjsAH_5nL5nfa_uh_-xpjMFKyZ7JVwH0cenQ6AYPFPs3OJBxt52X4Cq3qQSsSNTo3zURZ728kH0eRpCRJFWI5I1s3T9c6aejWx_NLRsosFTHrmfPLQGdTcP4nB5mGvrSZ6lkgFFkwkzwQbqy4ju3AxHno25jnKvSHugILXaWEpcVn4bdGKrDy9Rpt1SRgolQ377PQDPZBKZ7LKjBTKD68LYaKhDTA4FJ4Yu534cswdHB2Ug2rh7XjeRhGTPlFxdsC9LVb93oRBuRDO8laSzk0CVz9tfY_AaV8Hx4 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NTttAEB7RQBGXtpSWBmhZpHK0Yu-uvfYBVVCIgERRhCji5tq7a9VSYtM4gNJTX6Ov0SMPwUPwJJ21nXAqtxy4-GJppPV8M_uN5w_gs6uCRHAuLU9TE6BE0kJWrS1mJ1x5SUSrPu6Lruj1_MvLoL8Ad9NeGFNWOfWJpaNWuTT_yFvUhE3ILXzeSuqyiP5h-8vVT8tskDKZ1uk6jQoiHT25xfCt2Ds5RF3vUto-Ov96bNUbBizJXD62pAqkzRJpWLr2RGQzmTiacRp7kfKlkAIhH9sx0hjmcOlwR9perF3JKXKFyGEo9wUsCiQZvAGLB0e9_tksh8FFucjSYa7Jtfq87g60md8amkmZjsAH_z-zLW-49uvn_G3ewKuaV5P9yhBWYUFnb-FltWlzsganB2WBvkJ7u9GKRMPJIE-Vdf-XlIMq0oykmUKUF2R_8OuHTod69PD7T0Hq_BUxi5vLa0IX7-DbXA7yHhpZnukPQCjyYyZ5INxEcZ3YgYkA0esxz1XoKXUTtqYKCmtfUISP2mnCzuw1WrFJzUSZzq-L0Iz8QSmey5qwXoEgvKrGjYQ0wLBTeGLjaeHbsIxKD7snvc4mrCC8_KoUbgsa49G1_ghL8macFqNPNU4JfJ-3-v8BfZspOA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Blood-derived+amyloid-%CE%B2+protein+induces+Alzheimer%E2%80%99s+disease+pathologies&rft.jtitle=Molecular+psychiatry&rft.au=Bu%2C+X-L&rft.au=Xiang%2C+Y&rft.au=W-S%2C+Jin&rft.au=Wang%2C+J&rft.date=2018-09-01&rft.pub=Nature+Publishing+Group&rft.issn=1359-4184&rft.eissn=1476-5578&rft.volume=23&rft.issue=9&rft.spage=1948&rft.epage=1956&rft_id=info:doi/10.1038%2Fmp.2017.204&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1359-4184&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1359-4184&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1359-4184&client=summon |