Targeting a Novel ER/HOXB7 Signaling Loop in Tamoxifen-Resistant Breast Cancer

The majority of patients with breast cancer present with an estrogen receptor-positive (ER(+)) tumor, and the endocrine agent tamoxifen is a mainstay for their treatment. Unfortunately, however, resistance remains a major problem because most patients who respond eventually have a recurrence. Thus,...

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Veröffentlicht in:	Cancer discovery Jg. 5; H. 9; S. 909
Hauptverfasser:	Heideman, Marinus R, Frei, Anna, Hynes, Nancy E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.09.2015
Schlagworte:	Animals Antineoplastic Agents, Hormonal - pharmacology Drug Resistance, Neoplasm - genetics Estrogen Receptor alpha - metabolism Female Gene Expression Regulation, Neoplastic Homeodomain Proteins - metabolism Humans Receptor, ErbB-2 - metabolism
ISSN:	2159-8290, 2159-8290
Online-Zugang:	Weitere Angaben
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