Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

[Display omitted] The calcitonin receptor (CTR) is a class B G protein-coupled receptor that is a therapeutic target for the treatment of hypercalcaemia of malignancy, Paget’s disease and osteoporosis. In primates, the CTR is subject to alternative splicing, with a unique, primate-specific splice va...

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Veröffentlicht in:	Biochemical pharmacology Jg. 148; S. 111 - 129
Hauptverfasser:	Dal Maso, Emma, Just, Rasmus, Hick, Caroline, Christopoulos, Arthur, Sexton, Patrick M., Wootten, Denise, Furness, Sebastian G.B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Inc 01.02.2018
Schlagworte:	Animals Calcitonin Calcitonin receptor Cercopithecus aethiops COS Cells G protein-coupled receptor Gene Expression Regulation HEK293 Cells Humans Polymorphism Polymorphism, Genetic Protein Isoforms Receptors, Calcitonin - genetics Receptors, Calcitonin - metabolism Signal Transduction - physiology Splice variant G protein-coupled receptor Splice variant Calcitonin receptor Calcitonin Polymorphism
ISSN:	0006-2952, 1873-2968, 1873-2968
Online-Zugang:	Volltext
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