Single-chain bolalipids PC-C24-PC and PC-C32-PC: impact on skin permeation and penetration of caffeine ex vivo, structural organization of the stratum corneum and corneocyte morphology

•synthetic symmetric single-chain bolalipids (SSCBs) do not promote the skin penetration of caffeine ex vivo using the porcine ear model.•both quantitative confocal Raman spectroscopy ex vivo and classic diffusion cell studies support this observation.•SSCBs can be tracked after penetration into por...

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Bibliographic Details
Published in:	European journal of pharmaceutical sciences Vol. 212; p. 107205
Main Authors:	Abdelrahman, Namarig, Schmolz, Jakob, Schwarzinger, Jacqueline, Drescher, Simon, Riethmüller, Christoph, Dailey, Lea Ann, Klang, Victoria
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2025
Subjects:	Administration, Cutaneous Animals ATR-FTIR Bolalipids Caffeine Caffeine - administration & dosage Caffeine - chemistry Caffeine - pharmacokinetics Confocal Raman spectroscopy Epidermis - metabolism Penetration, permeation Permeability Skin - drug effects Skin - metabolism Skin Absorption - drug effects Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman Swine Penetration, permeation Bolalipids Confocal Raman spectroscopy ATR-FTIR Caffeine
ISSN:	0928-0987, 1879-0720, 1879-0720
Online Access:	Get full text
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