The construction of multi-factor crossover designs in animal husbandry studies

For ethical reasons it is important to try to obtain as much useful information as possible from an animal experiment whilst minimizing the number of animals used. Crossover designs, where applicable, provide an ideal framework for achieving this. If two or more treatment factors are included in the...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Pharmaceutical statistics : the journal of the pharmaceutical industry Ročník 7; číslo 3; s. 179 - 194
Hlavní autori:	Bate, S.T., Boxall, J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Chichester, UK John Wiley & Sons, Ltd 01.07.2008
Predmet:	Animal Husbandry - methods Animal Husbandry - statistics & numerical data Animals balance carry-over Cross-Over Studies crossover Dogs Drug Industry - methods Drug Industry - statistics & numerical data Female Male orthogonality Research Design - statistics & numerical data universal optimality
ISSN:	1539-1604, 1539-1612, 1539-1612
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	For ethical reasons it is important to try to obtain as much useful information as possible from an animal experiment whilst minimizing the number of animals used. Crossover designs, where applicable, provide an ideal framework for achieving this. If two or more treatment factors are included in the crossover design then the reduction in total animal usage can be considerable. In this paper we consider such designs, defined as multi‐factor crossover designs. The designs are applicable when there are several different treatment factors, each at t levels, to be applied to the experimental units. The motivation for investigating these designs was a study conducted at GlaxoSmithKline to determine the preference of male and female dogs for t=5 different types of bed and t=5 different bedding conditions. A construction method is given for forming universally optimal designs for t not too large. Also given is an example for the special case where the number of treatment levels t=6. Copyright © 2007 John Wiley & Sons, Ltd.
Bibliografia:	ark:/67375/WNG-GSJ329KD-R ArticleID:PST288 istex:4CB3DFB57557D934740A8D5A23E1B5B7D91589EA ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1539-1604 1539-1612 1539-1612
DOI:	10.1002/pst.288