Methods for evaluating penetration of drug into the skin: A review
Background Skin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug delivery system (TDDS) plays a major role in managing dermal infections and attaining sustained plasma drug concentration. Thus, eval...
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| Veröffentlicht in: | Skin research and technology Jg. 27; H. 3; S. 299 - 308 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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England
John Wiley & Sons, Inc
01.05.2021
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| ISSN: | 0909-752X, 1600-0846, 1600-0846 |
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| Abstract | Background
Skin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug delivery system (TDDS) plays a major role in managing dermal infections and attaining sustained plasma drug concentration. Thus, evaluation of percutaneous penetration of the drug through the skin is important in developing TDDS for human use.
Material and methods
Various techniques are used for getting the desired drug penetration, permeation, and absorption through the skin in managing these dermal disorders. The development of novel pharmaceutical dosage forms for dermal use is much explored in the current era. However, it is very important to evaluate these methods to determine the bioequivalence and risk of these topically applied drugs, which ultimately penetrate and are absorbed through the skin.
Results
Currently, numerous skin permeation models are being developed and persuasively used in studying dermatopharmacokinetic (DPK) profile and various models have been developed, to evaluate the TDD which include ex vivo human skin, ex vivo animal skin, and artificial or reconstructed skin models.
Conclusion
This review discusses the general physiology of the skin, the physiochemical characteristics affecting particle penetration, understand the models used for human skin permeation studies and understanding their advantages, and disadvantages. |
|---|---|
| AbstractList | Skin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug delivery system (TDDS) plays a major role in managing dermal infections and attaining sustained plasma drug concentration. Thus, evaluation of percutaneous penetration of the drug through the skin is important in developing TDDS for human use.BACKGROUNDSkin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug delivery system (TDDS) plays a major role in managing dermal infections and attaining sustained plasma drug concentration. Thus, evaluation of percutaneous penetration of the drug through the skin is important in developing TDDS for human use.Various techniques are used for getting the desired drug penetration, permeation, and absorption through the skin in managing these dermal disorders. The development of novel pharmaceutical dosage forms for dermal use is much explored in the current era. However, it is very important to evaluate these methods to determine the bioequivalence and risk of these topically applied drugs, which ultimately penetrate and are absorbed through the skin.MATERIAL AND METHODSVarious techniques are used for getting the desired drug penetration, permeation, and absorption through the skin in managing these dermal disorders. The development of novel pharmaceutical dosage forms for dermal use is much explored in the current era. However, it is very important to evaluate these methods to determine the bioequivalence and risk of these topically applied drugs, which ultimately penetrate and are absorbed through the skin.Currently, numerous skin permeation models are being developed and persuasively used in studying dermatopharmacokinetic (DPK) profile and various models have been developed, to evaluate the TDD which include ex vivo human skin, ex vivo animal skin, and artificial or reconstructed skin models.RESULTSCurrently, numerous skin permeation models are being developed and persuasively used in studying dermatopharmacokinetic (DPK) profile and various models have been developed, to evaluate the TDD which include ex vivo human skin, ex vivo animal skin, and artificial or reconstructed skin models.This review discusses the general physiology of the skin, the physiochemical characteristics affecting particle penetration, understand the models used for human skin permeation studies and understanding their advantages, and disadvantages.CONCLUSIONThis review discusses the general physiology of the skin, the physiochemical characteristics affecting particle penetration, understand the models used for human skin permeation studies and understanding their advantages, and disadvantages. BackgroundSkin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug delivery system (TDDS) plays a major role in managing dermal infections and attaining sustained plasma drug concentration. Thus, evaluation of percutaneous penetration of the drug through the skin is important in developing TDDS for human use.Material and methodsVarious techniques are used for getting the desired drug penetration, permeation, and absorption through the skin in managing these dermal disorders. The development of novel pharmaceutical dosage forms for dermal use is much explored in the current era. However, it is very important to evaluate these methods to determine the bioequivalence and risk of these topically applied drugs, which ultimately penetrate and are absorbed through the skin.ResultsCurrently, numerous skin permeation models are being developed and persuasively used in studying dermatopharmacokinetic (DPK) profile and various models have been developed, to evaluate the TDD which include ex vivo human skin, ex vivo animal skin, and artificial or reconstructed skin models.ConclusionThis review discusses the general physiology of the skin, the physiochemical characteristics affecting particle penetration, understand the models used for human skin permeation studies and understanding their advantages, and disadvantages. Background Skin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug delivery system (TDDS) plays a major role in managing dermal infections and attaining sustained plasma drug concentration. Thus, evaluation of percutaneous penetration of the drug through the skin is important in developing TDDS for human use. Material and methods Various techniques are used for getting the desired drug penetration, permeation, and absorption through the skin in managing these dermal disorders. The development of novel pharmaceutical dosage forms for dermal use is much explored in the current era. However, it is very important to evaluate these methods to determine the bioequivalence and risk of these topically applied drugs, which ultimately penetrate and are absorbed through the skin. Results Currently, numerous skin permeation models are being developed and persuasively used in studying dermatopharmacokinetic (DPK) profile and various models have been developed, to evaluate the TDD which include ex vivo human skin, ex vivo animal skin, and artificial or reconstructed skin models. Conclusion This review discusses the general physiology of the skin, the physiochemical characteristics affecting particle penetration, understand the models used for human skin permeation studies and understanding their advantages, and disadvantages. Skin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug delivery system (TDDS) plays a major role in managing dermal infections and attaining sustained plasma drug concentration. Thus, evaluation of percutaneous penetration of the drug through the skin is important in developing TDDS for human use. Various techniques are used for getting the desired drug penetration, permeation, and absorption through the skin in managing these dermal disorders. The development of novel pharmaceutical dosage forms for dermal use is much explored in the current era. However, it is very important to evaluate these methods to determine the bioequivalence and risk of these topically applied drugs, which ultimately penetrate and are absorbed through the skin. Currently, numerous skin permeation models are being developed and persuasively used in studying dermatopharmacokinetic (DPK) profile and various models have been developed, to evaluate the TDD which include ex vivo human skin, ex vivo animal skin, and artificial or reconstructed skin models. This review discusses the general physiology of the skin, the physiochemical characteristics affecting particle penetration, understand the models used for human skin permeation studies and understanding their advantages, and disadvantages. |
| Author | Supe, Shibani Takudage, Pooja |
| Author_xml | – sequence: 1 givenname: Shibani orcidid: 0000-0001-5188-0130 surname: Supe fullname: Supe, Shibani email: shibanisupe@gmail.com organization: Institute of Chemical technology – sequence: 2 givenname: Pooja surname: Takudage fullname: Takudage, Pooja organization: Sinhgad College of Pharmacy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33095948$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/j.1365-2710.2007.00803.x 10.4172/2161‐1459.1000180 10.1517/13543784.6.12.1887 10.1211/0022357991777164 10.1016/j.ejpb.2011.11.009 10.1016/B978-0-08-100094-6.00010-9 10.3109/03639045.2013.828219 10.1016/S0168-3659(02)00056-1 10.4103/jphi.JPHI_35_16 10.1002/jps.21817 10.1016/S0035-9203(01)90158-0 10.4269/ajtmh.2010.10-0171 10.1111/1523-1747.ep12259184 10.1590/S1984-82502013000300004 10.1111/j.2042-7158.1994.tb03791.x 10.4161/derm.1.4.9501 10.1016/j.addr.2012.09.032 10.1007/978-3-662-47039-8 10.1016/0378-5173(91)90274-R 10.1016/S0190-9622(84)80078-X 10.1016/S0168-3659(98)00060-1 10.1159/000235827 10.1016/0378-4347(91)80049-I 10.1159/000091978 10.2174/1567201052772915 10.1080/10717540500455975 10.1016/j.fct.2014.10.017 10.2903/j.efsa.2017.4873 10.1039/C5RA24516H 10.1016/S0939-6411(01)00166-7 10.1016/S0939-6411(03)00021-3 10.1016/j.cocis.2012.02.001 10.1177/026119299902700504 10.1002/jat.3004 10.55782/ane-2004-1504 10.1007/978-1-349-58632-5_51 10.1016/j.ejpb.2005.03.004 10.1111/1523-1747.ep12524077 10.1007/s11095-006-9206-z 10.1016/S0731-7085(97)00238-0 10.1016/0378-5173(95)04278-4 10.1016/j.addr.2012.10.003 10.1517/17425247.2012.701204 10.1111/j.2042-7158.1995.tb05725.x 10.3109/09687688.2010.522203 10.4103/0973-8398.72115 10.1208/s12249-012-9839-7 10.1034/j.1600-0625.2000.009003165.x 10.1517/17425255.2013.816284 10.2174/092986712803306358 10.1586/edm.12.32 10.1021/nl801323y 10.1038/nbt.1504 10.1016/j.jconrel.2004.08.016 10.1007/s11095-007-9429-7 10.1128/AAC.42.12.3092 10.1590/s1984-82502016000300018 10.1128/AAC.38.9.2221 10.1016/S0378-5173(96)04766-7 10.3109/03639045.2016.1171334 10.1002/9781118140505.ch5 10.1159/000093119 10.1016/j.ejps.2008.05.002 10.1046/j.1523-1747.2001.01258.x 10.2165/00128071-200102050-00001 10.18433/J3201Z 10.1016/S0168-3659(01)00394-7 10.1007/s40265-013-0069-4 10.1002/aic.690210522 10.1016/j.ejps.2015.02.018 10.1111/j.1600-0846.2006.00179.x 10.1016/j.ejpb.2008.08.008 10.1023/A:1011067300397 10.4103/0975-1483.55741 10.1016/S0024-3205(98)00071-X |
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| References | 2015; 35 2010; 99 2017; 7 2004; 64 2013; 65 2015; 75 2000; 9 2002; 98 2008; 34 2012; 19 2008; 8 2012; 17 2005; 60 2007; 32 1997; 6 2018; 44 2012; 13 2013; 5 1998; 42 2003; 55 2013; 9 1997; 146 1998; 17 2010; 27 2015; 05 1980; 75 1984; 10 2008; 25 2008; 26 2016; 42 1994; 38 1996; 132 1999; 51 2001; 18 2010; 4 2007; 24 2001; 95 1998; 56 2001; 52 2012; 64 2004; 100 2009; 22 2012; 80 2013; 49 2012 2006; 13 1991; 76 2010 1999; 27 2002; 3 1970; 54 2007 2016; 52 2006; 19 1994; 46 2002; 81 2004 2008; 11 1998; 62 2014; 40 2007; 13 2010; 83 2010; 1358 2016; 6 1989; 11 1991; 563 2017; 15 2009; 72 1995; 47 2013; 73 2013; 137 2016 2015 2001; 2 1975; 21 2005; 2 2012; 7 2012; 4 2009; 1 2016; 8 2001; 75 2012; 9 2001; 116 e_1_2_9_75_1 e_1_2_9_31_1 e_1_2_9_50_1 e_1_2_9_73_1 e_1_2_9_79_1 e_1_2_9_10_1 Dubey A (e_1_2_9_22_1) 2012; 4 e_1_2_9_35_1 e_1_2_9_56_1 e_1_2_9_77_1 e_1_2_9_12_1 e_1_2_9_33_1 e_1_2_9_54_1 Scientific Committee on Consumer Safety (e_1_2_9_17_1) 2010; 1358 e_1_2_9_71_1 Shelke SJ (e_1_2_9_18_1) 2013; 5 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_58_1 Orłowska‐Majdak M (e_1_2_9_70_1) 2004; 64 Mishra J (e_1_2_9_59_1) 2013; 137 e_1_2_9_64_1 e_1_2_9_87_1 Aly R (e_1_2_9_52_1) 1989; 11 e_1_2_9_20_1 e_1_2_9_62_1 e_1_2_9_45_1 e_1_2_9_68_1 e_1_2_9_83_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_66_1 e_1_2_9_85_1 e_1_2_9_8_1 e_1_2_9_6_1 e_1_2_9_81_1 e_1_2_9_4_1 e_1_2_9_60_1 e_1_2_9_2_1 e_1_2_9_26_1 e_1_2_9_49_1 e_1_2_9_28_1 e_1_2_9_47_1 Maibach HI (e_1_2_9_34_1) 1984; 10 Garnier T (e_1_2_9_3_1) 2002; 3 e_1_2_9_30_1 e_1_2_9_53_1 e_1_2_9_74_1 e_1_2_9_51_1 e_1_2_9_72_1 e_1_2_9_11_1 e_1_2_9_57_1 e_1_2_9_78_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_55_1 e_1_2_9_76_1 Schaefer UF (e_1_2_9_41_1) 2007 Bhowmik B (e_1_2_9_21_1) 2016; 8 Abd E (e_1_2_9_42_1) 2016; 8 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_36_1 e_1_2_9_19_1 e_1_2_9_63_1 e_1_2_9_88_1 e_1_2_9_40_1 e_1_2_9_61_1 e_1_2_9_46_1 e_1_2_9_67_1 e_1_2_9_84_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_65_1 e_1_2_9_86_1 e_1_2_9_7_1 e_1_2_9_80_1 e_1_2_9_5_1 e_1_2_9_82_1 e_1_2_9_9_1 e_1_2_9_25_1 e_1_2_9_27_1 e_1_2_9_48_1 e_1_2_9_69_1 Malan SF (e_1_2_9_29_1) 2002; 98 |
| References_xml | – volume: 47 start-page: 8 issue: 1 year: 1995 end-page: 16 article-title: The factors that influence skin penetration of solutes publication-title: J Pharm Pharmacol – volume: 15 issue: 6 year: 2017 article-title: Guidance on dermal absorption publication-title: EFSA Journal – volume: 80 start-page: 604 issue: 3 year: 2012 end-page: 614 article-title: In vitro vs. in vivo tape stripping: Validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions publication-title: Eur J Pharm Biopharm – volume: 2 start-page: 23 issue: 1 year: 2005 end-page: 33 article-title: Transdermal drug delivery: penetration enhancement techniques publication-title: Curr Drug Deliv – volume: 26 start-page: 1261 issue: 11 year: 2008 end-page: 1268 article-title: Transdermal drug delivery publication-title: Nat Biotechnol – volume: 35 start-page: 1 issue: 1 year: 2015 end-page: 10 article-title: Animal models for percutaneous absorption publication-title: J Appl Toxicol – volume: 95 start-page: 184 issue: 2 year: 2001 end-page: 186 article-title: Efficacious topical treatment for human cutaneous leishmaniasis with ethanolic lipid amphotericin B publication-title: Trans R Soc Trop Med Hyg – volume: 99 start-page: 21 issue: 1 year: 2010 end-page: 50 article-title: Penetration of nanoparticles and nanomaterials in the skin: Fiction or reality? publication-title: J Pharm Sci – volume: 42 start-page: 1742 issue: 11 year: 2016 end-page: 1751 article-title: In vitro models to estimate drug penetration through the compromised stratum corneum barrier publication-title: Drug Dev Ind Pharm – volume: 34 start-page: 203 issue: 4–5 year: 2008 end-page: 222 article-title: Liposomes and skin: From drug delivery to model membranes publication-title: Eur J Pharm Sci – volume: 98 start-page: 385 issue: 7–8 year: 2002 end-page: 391 article-title: Physicochemical properties of drugs and membrane permeability publication-title: S Afr J Sci – volume: 75 start-page: 297 issue: 3 year: 2001 end-page: 306 article-title: Application of the minimal trauma tissue biopsy to transdermal clinical pharmacokinetic studies publication-title: J Control Release – volume: 22 start-page: 231 issue: 5 year: 2009 end-page: 239 article-title: Experimental models in predicting topical antifungal efficacy: practical aspects and challenges publication-title: Skin Pharmacol Physiol – volume: 42 start-page: 3092 issue: 12 year: 1998 end-page: 3096 article-title: Efficacious topical treatment for murine cutaneous leishmaniasis with ethanolic formulations of amphotericin B publication-title: Antimicrob Agents Chemother – volume: 9 start-page: 165 issue: 3 year: 2000 end-page: 169 article-title: The 500 Dalton rule for the skin penetration of chemical compounds and drugs publication-title: Exp Dermatol – volume: 100 start-page: 181 issue: 2 year: 2004 end-page: 189 article-title: Excised porcine skin experimental systems to validate quantitative microdialysis methods for determination of drugs in skin after topical application publication-title: J Control Release – volume: 10 start-page: 152 issue: 1 year: 1984 article-title: Dermatologie formulations: percutaneous absorption publication-title: J Am Acad Dermatol – volume: 137 start-page: 767 issue: 4 year: 2013 end-page: 776 article-title: Evaluation of toxicity & therapeutic efficacy of a new liposomal formulation of amphotericin B in a mouse model publication-title: Indian J Med Res – volume: 563 start-page: 407 issue: 2 year: 1991 end-page: 413 article-title: High‐performance liquid chromatographic determination of citropten and bergapten in suction blister fluid after solar product application in humans publication-title: J Chromatogr B Biomed Sci Appl – volume: 18 start-page: 367 issue: 3 year: 2001 end-page: 373 article-title: Dermal pharmacokinetics of microemulsion formulations determined by in vivo microdialysis publication-title: Pharm Res – volume: 19 start-page: 106 issue: 2 year: 2006 end-page: 121 article-title: Overcoming the stratum corneum: the modulation of skin penetration publication-title: Skin Pharmacol Physiol – volume: 19 start-page: 4671 issue: 27 year: 2012 end-page: 4677 article-title: Transdermal drug delivery in vitro using diffusion cells publication-title: Curr Med Chem – volume: 6 start-page: 1887 issue: 12 year: 1997 end-page: 1937 article-title: Drug delivery across the skin publication-title: Expert Opin Investig Drugs – volume: 64 start-page: 177 issue: 2 year: 2004 end-page: 188 article-title: Microdialysis of the brain structures: application in behavioral research on vasopressin and oxytocin publication-title: Acta Neurobiol Exp (Wars) – volume: 73 start-page: 919 issue: 9 year: 2013 end-page: 934 article-title: Formulations: a comparative review of efficacy and toxicity publication-title: Drugs – volume: 75 start-page: 39 year: 2015 end-page: 49 article-title: In vitro‐to‐in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine publication-title: Food Chem Toxicol – volume: 3 start-page: 538 issue: 4 year: 2002 end-page: 544 article-title: Topical treatment for cutaneous leishmaniasis publication-title: Curr Opin Investig Drugs – volume: 6 start-page: 20713 issue: 25 year: 2016 end-page: 20727 article-title: Aceclofenac–β‐cyclodextrin‐vesicles: a dual carrier approach for skin with enhanced stability, efficacy and dermatokinetic profile publication-title: RSC Adv – volume: 24 start-page: 1014 issue: 5 year: 2007 end-page: 1025 article-title: AAPS‐FDA Workshop White Paper: microdialysis principles, application and regulatory perspectives publication-title: Pharm Res – volume: 72 start-page: 317 issue: 2 year: 2009 end-page: 323 article-title: The tape stripping procedure – evaluation of some critical parameters publication-title: Eur J Pharm Biopharm – volume: 55 start-page: 271 issue: 3 year: 2003 end-page: 277 article-title: Liposomes increase skin penetration of entrapped and non‐entrapped hydrophilic substances into human skin: a skin penetration and confocal laser scanning microscopy study publication-title: Eur J Pharm Biopharm – volume: 8 start-page: 2779 issue: 9 year: 2008 end-page: 2787 article-title: In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR publication-title: Nano Lett – year: 2004 – volume: 1 start-page: 110 issue: 2 year: 2009 article-title: Skin penetration enhancement techniques publication-title: J Young Pharm – volume: 1358 start-page: 1 year: 2010 end-page: 14 article-title: Basic criteria for the in vitro assessment of dermal absorption of cosmetic ingredients publication-title: Eur Comm – volume: 38 start-page: 2221 issue: 9 year: 1994 end-page: 2223 article-title: Penetration of cefotetan into suction skin blister fluid and tissue homogenates in patients undergoing abdominal surgery publication-title: Antimicrob Agents Chemother – volume: 32 start-page: 143 issue: 2 year: 2007 end-page: 148 article-title: Evaluation of skin penetration of topically applied drugs in humans by cutaneous microdialysis: acyclovir vs. salicylic acid publication-title: J Clin Pharm Ther – start-page: 1 year: 2010 end-page: 53 – volume: 1 start-page: 197 issue: 4 year: 2009 end-page: 206 article-title: Nanoparticles and their interactions with the dermal barrier publication-title: Dermatoendocrinology – volume: 4 start-page: 705 issue: 2 year: 2012 end-page: 714 article-title: Nano structured lipid carriers: a novel topical drug delivery system publication-title: Int J PharmTech Res – year: 2015 – volume: 13 start-page: 175 issue: 3 year: 2006 end-page: 187 article-title: Dermal and transdermal drug delivery systems: current and future prospects publication-title: Drug Deliv – volume: 05 start-page: 1 issue: 04 year: 2015 end-page: 11 article-title: Microdialysis techniques in pharmacokinetic and biomarker studies past, present and future directions a review publication-title: Clin Exp Pharmacol – volume: 60 start-page: 167 issue: 2 year: 2005 end-page: 178 article-title: The human epidermis models EpiSkin®, SkinEthic® and EpiDerm®: An evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport publication-title: Eur J Pharm Biopharm – volume: 54 start-page: 399 issue: 5 year: 1970 end-page: 404 article-title: Absorption of some organic compounds through the skin in man publication-title: J Invest Dermatol – volume: 5 start-page: 2739 issue: 3 year: 2013 end-page: 2763 article-title: Topical gel: a novel approach for development of topical drug delivery system publication-title: Int J Pharm Technol – volume: 51 start-page: 1339 issue: 12 year: 1999 end-page: 1357 article-title: Evaluation and prediction of drug permeation publication-title: J Pharm Pharmacol – start-page: 155 year: 2016 end-page: 167 – volume: 44 start-page: 1 year: 2018 end-page: 36 – volume: 52 start-page: 527 issue: 3 year: 2016 end-page: 544 article-title: Evaluation of skin absorption of drugs from topical and transdermal formulations publication-title: Braz J Pharm Sci – volume: 40 start-page: 433 issue: 4 year: 2014 end-page: 440 article-title: Recent advances in gel technologies for topical and transdermal drug delivery publication-title: Drug Dev Ind Pharm – start-page: 85 year: 2012 end-page: 108 – volume: 52 start-page: 103 issue: 2 year: 2001 end-page: 112 article-title: Passive skin penetration enhancement and its quantification in vitro publication-title: Eur J Pharm Biopharm – volume: 17 start-page: 493 issue: 3 year: 1998 end-page: 499 article-title: Evaluation of a novel diffusion cell for in vitro transdermal permeation: effects of injection height, volume and temperature publication-title: J Pharm Biomed Anal – start-page: 3 year: 2007 end-page: 33 – volume: 11 start-page: 290 issue: 3 year: 1989 end-page: 303 article-title: Ciclopirox olamine lotion 1%: bioequivalence to ciclopirox olamine cream 1% and clinical efficacy in tinea pedis publication-title: Clin Ther – volume: 19 start-page: 232 issue: 4 year: 2006 end-page: 236 article-title: Hair follicles – a long‐term reservoir for drug delivery publication-title: Skin Pharmacol Physiol – volume: 64 start-page: 128 year: 2012 end-page: 137 article-title: Penetration enhancers publication-title: Adv Drug Deliv Rev – volume: 27 start-page: 247 issue: 7 year: 2010 end-page: 259 article-title: Interaction of nanoparticles and cell‐penetrating peptides with skin for transdermal drug delivery publication-title: Mol Membr Biol – volume: 11 start-page: 104 issue: 1 year: 2008 article-title: The tape‐stripping technique as a method for drug quantification in skin publication-title: J Pharm Pharm Sci – volume: 83 start-page: 1028 issue: 5 year: 2010 end-page: 1033 article-title: Lipsosomal amphotericin B for treatment of cutaneous leishmaniasis publication-title: Am J Trop Med Hyg – volume: 76 start-page: 217 issue: 3 year: 1991 end-page: 224 article-title: Effect of penetration enhancers on the phase transition of multilamellar liposomes of dipalmitoylphosphatidylcholine. A study by differential scanning calorimetry publication-title: Int J Pharm – volume: 4 start-page: 173 issue: 3 year: 2010 article-title: Physical and chemical penetration enhancers in transdermal drug delivery system publication-title: Asian J Pharm – volume: 13 start-page: 19 issue: 1 year: 2007 end-page: 24 article-title: Porcine ear skin: an in vitro model for human skin publication-title: Ski Res Technol – volume: 116 start-page: 434 issue: 3 year: 2001 end-page: 442 article-title: In vivo confocal raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles publication-title: J Invest Dermatol – volume: 75 start-page: 10 year: 2015 end-page: 24 article-title: In vitro skin models as a tool in optimization of drug formulation publication-title: Eur J Pharm Sci – volume: 8 start-page: 169 issue: 4 year: 2016 end-page: 178 article-title: Recent trends and advances in fungal drug delivery publication-title: J Chem Pharm Res – volume: 75 start-page: 421 issue: 5 year: 1980 end-page: 424 article-title: Biochemical composition of suction blister fluid determined by high resolution multicomponent analysis (Capillary Gas Chromatography—Mass Spectrometry and Two‐Dimensional Electrophoresis) publication-title: J Invest Dermatol – volume: 17 start-page: 156 issue: 3 year: 2012 end-page: 165 article-title: Penetration of drugs through skin, a complex rate‐controlling membrane publication-title: Curr Opin Colloid Interface Sci – volume: 9 start-page: 1083 issue: 9 year: 2012 end-page: 1097 article-title: Drug delivery systems for the topical treatment of cutaneous leishmaniasis publication-title: Expert Opin Drug Deliv – volume: 9 start-page: 1255 issue: 10 year: 2013 end-page: 1263 article-title: Reconstructed skin models as emerging tools for drug absorption studies publication-title: Expert Opin Drug Metab Toxicol – volume: 81 start-page: 225 issue: 3 year: 2002 end-page: 233 article-title: Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration publication-title: J Control Release – volume: 2 start-page: 275 issue: 5 year: 2001 end-page: 280 article-title: Progress in methodologies for evaluating bioequivalence of topical formulations publication-title: Am J Clin Dermatol – volume: 132 start-page: 23 issue: 1–2 year: 1996 end-page: 32 article-title: Epidermal permeability: Penetrant structure relationships. 2. The effect of h‐bonding groups in penetrants on their diffusion through the stratum corneum publication-title: Int J Pharm – volume: 46 start-page: 261 issue: 4 year: 1994 end-page: 269 article-title: Sesquiterpene components of volatile oils as skin penetration enhancers for the hydrophilic permeant 5‐fluorouracil publication-title: J Pharm Pharmacol – volume: 13 start-page: 1110 issue: 4 year: 2012 end-page: 1115 article-title: Understanding the oral mucosal absorption and resulting clinical pharmacokinetics of asenapine publication-title: AAPS PharmSciTech – volume: 27 start-page: 723 issue: 5 year: 1999 end-page: 743 article-title: The use of human keratinocytes and human skin models for predicting skin irritation: the report and recommendations of ECVAM Workshop 38 publication-title: ATLA Altern to Lab Anim – volume: 7 start-page: 383 issue: 4 year: 2012 end-page: 397 article-title: Delivery of drugs applied topically to the skin publication-title: Expert Rev Dermatol – volume: 62 start-page: PL227 issue: 15 year: 1998 end-page: PL234 article-title: Comparison of three different experimental methods for the assessment of peripheral compartment pharmacokinetics in humans publication-title: Life Sci – volume: 146 start-page: 41 issue: 1 year: 1997 end-page: 54 article-title: A lamellar matrix model for stratum corneum intercellular lipids. V. Effects of terpene penetration enhancers on the structure and thermal behaviour of the matrix publication-title: Int J Pharm – volume: 21 start-page: 985 issue: 5 year: 1975 end-page: 996 article-title: Drug permeation through human skin: Theory andinvitro experimental measurement publication-title: AIChE J – volume: 49 start-page: 423 issue: 3 year: 2013 end-page: 434 article-title: Basic considerations in the dermatokinetics of topical formulations publication-title: Brazilian J Pharm Sci – volume: 65 start-page: 104 issue: 1 year: 2013 end-page: 120 article-title: Advanced materials and processing for drug delivery: the past and the future publication-title: Adv Drug Deliv Rev – volume: 56 start-page: 7 issue: 1–3 year: 1998 end-page: 21 article-title: Methods for quantitative determination of drug localized in the skin publication-title: J Control Release – volume: 8 start-page: 163 year: 2016 end-page: 176 article-title: Skin models for the testing of transdermal drugs publication-title: Clin Pharmacol Adv Appl – volume: 7 start-page: 10 issue: 1 year: 2017 article-title: Formulation and evaluation of transdermal drug delivery of topiramate publication-title: Int J Pharm Investig – volume: 25 start-page: 87 issue: 1 year: 2008 end-page: 103 article-title: In vivo methods for the assessment of topical drug bioavailability publication-title: Pharm Res – ident: e_1_2_9_11_1 doi: 10.1111/j.1365-2710.2007.00803.x – ident: e_1_2_9_71_1 doi: 10.4172/2161‐1459.1000180 – ident: e_1_2_9_25_1 doi: 10.1517/13543784.6.12.1887 – volume: 8 start-page: 163 year: 2016 ident: e_1_2_9_42_1 article-title: Skin models for the testing of transdermal drugs publication-title: Clin Pharmacol Adv Appl – ident: e_1_2_9_79_1 doi: 10.1211/0022357991777164 – ident: e_1_2_9_57_1 doi: 10.1016/j.ejpb.2011.11.009 – ident: e_1_2_9_86_1 doi: 10.1016/B978-0-08-100094-6.00010-9 – ident: e_1_2_9_74_1 doi: 10.3109/03639045.2013.828219 – ident: e_1_2_9_9_1 doi: 10.1016/S0168-3659(02)00056-1 – ident: e_1_2_9_47_1 doi: 10.4103/jphi.JPHI_35_16 – ident: e_1_2_9_40_1 doi: 10.1002/jps.21817 – ident: e_1_2_9_80_1 doi: 10.1016/S0035-9203(01)90158-0 – ident: e_1_2_9_5_1 doi: 10.4269/ajtmh.2010.10-0171 – ident: e_1_2_9_24_1 doi: 10.1111/1523-1747.ep12259184 – volume: 8 start-page: 169 issue: 4 year: 2016 ident: e_1_2_9_21_1 article-title: Recent trends and advances in fungal drug delivery publication-title: J Chem Pharm Res – volume: 98 start-page: 385 issue: 7 year: 2002 ident: e_1_2_9_29_1 article-title: Physicochemical properties of drugs and membrane permeability publication-title: S Afr J Sci – ident: e_1_2_9_13_1 doi: 10.1590/S1984-82502013000300004 – ident: e_1_2_9_35_1 doi: 10.1111/j.2042-7158.1994.tb03791.x – ident: e_1_2_9_83_1 doi: 10.4161/derm.1.4.9501 – ident: e_1_2_9_37_1 doi: 10.1016/j.addr.2012.09.032 – start-page: 3 volume-title: Drug Absorption Studies year: 2007 ident: e_1_2_9_41_1 – ident: e_1_2_9_33_1 doi: 10.1007/978-3-662-47039-8 – ident: e_1_2_9_28_1 doi: 10.1016/0378-5173(91)90274-R – volume: 10 start-page: 152 issue: 1 year: 1984 ident: e_1_2_9_34_1 article-title: Dermatologie formulations: percutaneous absorption publication-title: J Am Acad Dermatol doi: 10.1016/S0190-9622(84)80078-X – ident: e_1_2_9_82_1 doi: 10.1016/S0168-3659(98)00060-1 – ident: e_1_2_9_51_1 doi: 10.1159/000235827 – ident: e_1_2_9_66_1 doi: 10.1016/0378-4347(91)80049-I – ident: e_1_2_9_2_1 doi: 10.1159/000091978 – ident: e_1_2_9_19_1 doi: 10.2174/1567201052772915 – ident: e_1_2_9_6_1 doi: 10.1080/10717540500455975 – ident: e_1_2_9_87_1 doi: 10.1016/j.fct.2014.10.017 – volume: 137 start-page: 767 issue: 4 year: 2013 ident: e_1_2_9_59_1 article-title: Evaluation of toxicity & therapeutic efficacy of a new liposomal formulation of amphotericin B in a mouse model publication-title: Indian J Med Res – ident: e_1_2_9_16_1 doi: 10.2903/j.efsa.2017.4873 – ident: e_1_2_9_32_1 doi: 10.1039/C5RA24516H – ident: e_1_2_9_44_1 – ident: e_1_2_9_27_1 doi: 10.1016/S0939-6411(01)00166-7 – ident: e_1_2_9_54_1 doi: 10.1016/S0939-6411(03)00021-3 – ident: e_1_2_9_30_1 doi: 10.1016/j.cocis.2012.02.001 – ident: e_1_2_9_49_1 doi: 10.1177/026119299902700504 – ident: e_1_2_9_12_1 doi: 10.1002/jat.3004 – volume: 64 start-page: 177 issue: 2 year: 2004 ident: e_1_2_9_70_1 article-title: Microdialysis of the brain structures: application in behavioral research on vasopressin and oxytocin publication-title: Acta Neurobiol Exp (Wars) doi: 10.55782/ane-2004-1504 – ident: e_1_2_9_39_1 doi: 10.1007/978-1-349-58632-5_51 – ident: e_1_2_9_85_1 doi: 10.1016/j.ejpb.2005.03.004 – ident: e_1_2_9_64_1 doi: 10.1111/1523-1747.ep12524077 – ident: e_1_2_9_69_1 doi: 10.1007/s11095-006-9206-z – ident: e_1_2_9_53_1 doi: 10.1016/S0731-7085(97)00238-0 – ident: e_1_2_9_78_1 doi: 10.1016/0378-5173(95)04278-4 – ident: e_1_2_9_15_1 doi: 10.1016/j.addr.2012.10.003 – ident: e_1_2_9_50_1 doi: 10.1517/17425247.2012.701204 – ident: e_1_2_9_4_1 doi: 10.1111/j.2042-7158.1995.tb05725.x – ident: e_1_2_9_26_1 doi: 10.3109/09687688.2010.522203 – ident: e_1_2_9_36_1 doi: 10.4103/0973-8398.72115 – ident: e_1_2_9_81_1 doi: 10.1208/s12249-012-9839-7 – ident: e_1_2_9_77_1 doi: 10.1034/j.1600-0625.2000.009003165.x – volume: 3 start-page: 538 issue: 4 year: 2002 ident: e_1_2_9_3_1 article-title: Topical treatment for cutaneous leishmaniasis publication-title: Curr Opin Investig Drugs – ident: e_1_2_9_67_1 doi: 10.1517/17425255.2013.816284 – ident: e_1_2_9_48_1 doi: 10.2174/092986712803306358 – ident: e_1_2_9_61_1 doi: 10.1586/edm.12.32 – ident: e_1_2_9_84_1 doi: 10.1021/nl801323y – volume: 11 start-page: 290 issue: 3 year: 1989 ident: e_1_2_9_52_1 article-title: Ciclopirox olamine lotion 1%: bioequivalence to ciclopirox olamine cream 1% and clinical efficacy in tinea pedis publication-title: Clin Ther – ident: e_1_2_9_7_1 doi: 10.1038/nbt.1504 – ident: e_1_2_9_14_1 doi: 10.1016/j.jconrel.2004.08.016 – ident: e_1_2_9_56_1 doi: 10.1007/s11095-007-9429-7 – volume: 5 start-page: 2739 issue: 3 year: 2013 ident: e_1_2_9_18_1 article-title: Topical gel: a novel approach for development of topical drug delivery system publication-title: Int J Pharm Technol – ident: e_1_2_9_20_1 doi: 10.1128/AAC.42.12.3092 – ident: e_1_2_9_75_1 doi: 10.1590/s1984-82502016000300018 – volume: 4 start-page: 705 issue: 2 year: 2012 ident: e_1_2_9_22_1 article-title: Nano structured lipid carriers: a novel topical drug delivery system publication-title: Int J PharmTech Res – ident: e_1_2_9_65_1 doi: 10.1128/AAC.38.9.2221 – ident: e_1_2_9_88_1 doi: 10.1016/S0378-5173(96)04766-7 – ident: e_1_2_9_58_1 doi: 10.3109/03639045.2016.1171334 – ident: e_1_2_9_46_1 doi: 10.1002/9781118140505.ch5 – ident: e_1_2_9_31_1 doi: 10.1159/000093119 – ident: e_1_2_9_73_1 doi: 10.1016/j.ejps.2008.05.002 – ident: e_1_2_9_76_1 doi: 10.1046/j.1523-1747.2001.01258.x – ident: e_1_2_9_43_1 doi: 10.2165/00128071-200102050-00001 – ident: e_1_2_9_60_1 doi: 10.18433/J3201Z – ident: e_1_2_9_63_1 doi: 10.1016/S0168-3659(01)00394-7 – ident: e_1_2_9_72_1 doi: 10.1007/s40265-013-0069-4 – ident: e_1_2_9_10_1 doi: 10.1002/aic.690210522 – ident: e_1_2_9_8_1 doi: 10.1016/j.ejps.2015.02.018 – ident: e_1_2_9_23_1 doi: 10.1111/j.1600-0846.2006.00179.x – ident: e_1_2_9_55_1 doi: 10.1016/j.ejpb.2008.08.008 – ident: e_1_2_9_68_1 doi: 10.1023/A:1011067300397 – ident: e_1_2_9_38_1 doi: 10.4103/0975-1483.55741 – volume: 1358 start-page: 1 year: 2010 ident: e_1_2_9_17_1 article-title: Basic criteria for the in vitro assessment of dermal absorption of cosmetic ingredients publication-title: Eur Comm – ident: e_1_2_9_45_1 – ident: e_1_2_9_62_1 doi: 10.1016/S0024-3205(98)00071-X |
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Skin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the... Skin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug... BackgroundSkin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the... |
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| SubjectTerms | Dosage Drug delivery Drug delivery systems Franz diffusion Penetration percutaneous absorption Physiochemistry Skin tape stripping transdermal drug delivery system Transdermal medication |
| Title | Methods for evaluating penetration of drug into the skin: A review |
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