Methods for evaluating penetration of drug into the skin: A review

Background Skin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug delivery system (TDDS) plays a major role in managing dermal infections and attaining sustained plasma drug concentration. Thus, eval...

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Vydáno v:Skin research and technology Ročník 27; číslo 3; s. 299 - 308
Hlavní autoři: Supe, Shibani, Takudage, Pooja
Médium: Journal Article
Jazyk:angličtina
Vydáno: England John Wiley & Sons, Inc 01.05.2021
Témata:
Dosage
Drug delivery
Drug delivery systems
Franz diffusion
Penetration
percutaneous absorption
Physiochemistry
Skin
tape stripping
transdermal drug delivery system
Transdermal medication
Franz diffusion
percutaneous absorption
tape stripping
transdermal drug delivery system
penetration
ISSN:0909-752X, 1600-0846, 1600-0846
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Shrnutí:Background Skin being the largest organ of the human body plays a very important role in the permeation and penetration of the drug. In addition, the transdermal drug delivery system (TDDS) plays a major role in managing dermal infections and attaining sustained plasma drug concentration. Thus, evaluation of percutaneous penetration of the drug through the skin is important in developing TDDS for human use. Material and methods Various techniques are used for getting the desired drug penetration, permeation, and absorption through the skin in managing these dermal disorders. The development of novel pharmaceutical dosage forms for dermal use is much explored in the current era. However, it is very important to evaluate these methods to determine the bioequivalence and risk of these topically applied drugs, which ultimately penetrate and are absorbed through the skin. Results Currently, numerous skin permeation models are being developed and persuasively used in studying dermatopharmacokinetic (DPK) profile and various models have been developed, to evaluate the TDD which include ex vivo human skin, ex vivo animal skin, and artificial or reconstructed skin models. Conclusion This review discusses the general physiology of the skin, the physiochemical characteristics affecting particle penetration, understand the models used for human skin permeation studies and understanding their advantages, and disadvantages.
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ISSN:0909-752X
1600-0846
1600-0846
DOI:10.1111/srt.12968