STRATEGIES AND CHALLENGES IN METHOD DEVELOPMENT AND VALIDATION FOR THE ABSOLUTE QUANTIFICATION OF ENDOGENOUS BIOMARKER METABOLITES USING LIQUID CHROMATOGRAPHY‐TANDEM MASS SPECTROMETRY

Metabolomics is a dynamically evolving field, with a major application in identifying biomarkers for drug development and personalized medicine. Numerous metabolomic studies have identified endogenous metabolites that, in principle, are eligible for translation to clinical practice. However, few met...

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Bibliographic Details
Published in:	Mass spectrometry reviews Vol. 40; no. 1; pp. 31 - 52
Main Authors:	Khamis, Mona M., Adamko, Darryl J., El‐Aneed, Anas
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.01.2021
Subjects:	Biomarkers blank matrix Drug development endogenous biomarkers internal standards LC‐MS/MS Liquid chromatography Mass spectroscopy Metabolites Metabolomics Precision medicine validation LC-MS/MS endogenous biomarkers metabolomics blank matrix internal standards validation
ISSN:	0277-7037, 1098-2787, 1098-2787
Online Access:	Get full text
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