STRATEGIES AND CHALLENGES IN METHOD DEVELOPMENT AND VALIDATION FOR THE ABSOLUTE QUANTIFICATION OF ENDOGENOUS BIOMARKER METABOLITES USING LIQUID CHROMATOGRAPHY‐TANDEM MASS SPECTROMETRY

Metabolomics is a dynamically evolving field, with a major application in identifying biomarkers for drug development and personalized medicine. Numerous metabolomic studies have identified endogenous metabolites that, in principle, are eligible for translation to clinical practice. However, few met...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Mass spectrometry reviews Ročník 40; číslo 1; s. 31 - 52
Hlavní autori:	Khamis, Mona M., Adamko, Darryl J., El‐Aneed, Anas
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Wiley Subscription Services, Inc 01.01.2021
Predmet:	Biomarkers blank matrix Drug development endogenous biomarkers internal standards LC‐MS/MS Liquid chromatography Mass spectroscopy Metabolites Metabolomics Precision medicine validation LC-MS/MS endogenous biomarkers metabolomics blank matrix internal standards validation
ISSN:	0277-7037, 1098-2787, 1098-2787
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!