The spike‐and‐slab quantile LASSO for robust variable selection in cancer genomics studies

Data irregularity in cancer genomics studies has been widely observed in the form of outliers and heavy‐tailed distributions in the complex traits. In the past decade, robust variable selection methods have emerged as powerful alternatives to the nonrobust ones to identify important genes associated...

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Veröffentlicht in:	Statistics in medicine Jg. 43; H. 26; S. 4928 - 4983
Hauptverfasser:	Liu, Yuwen, Ren, Jie, Ma, Shuangge, Wu, Cen
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Hoboken, USA John Wiley & Sons, Inc 20.11.2024 Wiley Subscription Services, Inc
Schlagworte:	Bayes Theorem Cancer Computer Simulation expectation‐maximization (EM) algorithm Genomics Genomics - methods Humans Likelihood Functions Lung cancer Lung Neoplasms - genetics Melanoma - genetics Models, Statistical Neoplasms - genetics quantile LASSO regularized Bayesian quantile regression robust variable selection Skin Neoplasms - genetics spike‐and‐slab prior expectation‐maximization (EM) algorithm robust variable selection quantile LASSO regularized Bayesian quantile regression spike‐and‐slab prior
ISSN:	0277-6715, 1097-0258, 1097-0258
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Zusammenfassung:	Data irregularity in cancer genomics studies has been widely observed in the form of outliers and heavy‐tailed distributions in the complex traits. In the past decade, robust variable selection methods have emerged as powerful alternatives to the nonrobust ones to identify important genes associated with heterogeneous disease traits and build superior predictive models. In this study, to keep the remarkable features of the quantile LASSO and fully Bayesian regularized quantile regression while overcoming their disadvantage in the analysis of high‐dimensional genomics data, we propose the spike‐and‐slab quantile LASSO through a fully Bayesian spike‐and‐slab formulation under the robust likelihood by adopting the asymmetric Laplace distribution (ALD). The proposed robust method has inherited the prominent properties of selective shrinkage and self‐adaptivity to the sparsity pattern from the spike‐and‐slab LASSO (Roc̆ková and George, J Am Stat Associat, 2018, 113(521): 431–444). Furthermore, the spike‐and‐slab quantile LASSO has a computational advantage to locate the posterior modes via soft‐thresholding rule guided Expectation‐Maximization (EM) steps in the coordinate descent framework, a phenomenon rarely observed for robust regularization with nondifferentiable loss functions. We have conducted comprehensive simulation studies with a variety of heavy‐tailed errors in both homogeneous and heterogeneous model settings to demonstrate the superiority of the spike‐and‐slab quantile LASSO over its competing methods. The advantage of the proposed method has been further demonstrated in case studies of the lung adenocarcinomas (LUAD) and skin cutaneous melanoma (SKCM) data from The Cancer Genome Atlas (TCGA).
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0277-6715 1097-0258 1097-0258
DOI:	10.1002/sim.10196