Accelerated 3D‐GRASE imaging improves quantitative multiple post labeling delay arterial spin labeling

Purpose To investigate the impact of accelerated, single‐shot 3D‐GRASE acquisition on quantitative arterial spin labeling (ASL) with multiple and single post‐labeling delay (PLD) in terms of perfusion‐weighted SNR per unit scan time (TSNRPW) and quantification accuracy. Methods Five subjects were sc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Magnetic resonance in medicine Jg. 80; H. 6; S. 2475 - 2484
Hauptverfasser: Boland, Markus, Stirnberg, Rüdiger, Pracht, Eberhard D., Kramme, Johanna, Viviani, Roberto, Stingl, Julia, Stöcker, Tony
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Wiley Subscription Services, Inc 01.12.2018
Schlagworte:
3D‐GRASE
Acceleration
Blood flow
Blurring
Cerebral blood flow
Delay
Imaging
Labeling
Magnetic resonance imaging
multiple post labeling delay
Perfusion
Programmable logic controllers
pseudo‐continuous arterial spin labeling
Sampling
Shot
single‐shot
Spin labeling
Substantia alba
Substantia grisea
Time measurement
Transit time
Uncertainty
3D-GRASE
cerebral blood flow
single-shot
multiple post labeling delay
perfusion
pseudo-continuous arterial spin labeling
ISSN:0740-3194, 1522-2594, 1522-2594
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Purpose To investigate the impact of accelerated, single‐shot 3D‐GRASE acquisition on quantitative arterial spin labeling (ASL) with multiple and single post‐labeling delay (PLD) in terms of perfusion‐weighted SNR per unit scan time (TSNRPW) and quantification accuracy. Methods Five subjects were scanned on a 3T MRI scanner using the pseudo‐continuous arterial spin labeling (PCASL) technique with a 3D‐GRASE imaging sequence capable of parallel imaging acceleration. A 3‐inversion pulse background suppression was simulated and implemented in the sequence. Three time‐matched single PLD measurements, a segmented one without acceleration, 1 with conventional GRAPPA, and 1 with CAIPIRINHA sampling, were used to compare TSNRPW. Three time‐matched multiple PLD measurements with the identical imaging parameters were additionally evaluated (no acceleration vs. CAIPIRINHA sampling vs. CAIPIRINHA sampling with doubled number of PLDs). Cerebral blood flow and arterial transit time fit uncertainties were compared and used as a quality measure. Results The single PLD measurements show an 11% TSNRPW increase using CAIPIRINHA sampling instead of GRAPPA sampling, while the non‐accelerated scan exhibits 35% higher TSNRPW compared to the GRAPPA scan. However, taking advantage of the increased number of averages for multiple PLD acquisitions, a 14%/16% (gray matter) and 34%/36% (white matter) reduction of CBF fit uncertainty is observed with CAIPIRINHA sampling (6 PLDs/12 PLDs) compared to no acceleration. Conclusion Accelerated single‐shot 3D‐GRASE with PCASL allows for smaller quantification uncertainties than time‐matched segmented acquisitions. Corresponding single‐shot acquisitions with acceptable blurring and no intra‐volume motion render state‐of‐the‐art ASL methods in a clinically feasible time possible.
Bibliographie:Funding information
Federal Institute for Drugs and Medical Devices, Grant/Award Number: V‐15840/68502/2014‐17
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.27226