Progress and challenges in the prevention and control of nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide. Individuals with NAFLD have a high frequency of developing progressive liver disease and metabolism‐related comorbidities, which result from of a lack of awareness and poor surveillance of the disea...

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Bibliographic Details
Published in:Medicinal research reviews Vol. 39; no. 1; pp. 328 - 348
Main Authors: Cai, Jingjing, Zhang, Xiao‐Jing, Li, Hongliang
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.01.2019
Subjects:
animal model
awareness
Disease prevention
epidemiology
Fatty liver
Liver diseases
molecular target
nonalcoholic fatty liver disease (NAFLD)
epidemiology
nonalcoholic fatty liver disease (NAFLD)
awareness
animal model
molecular target
ISSN:0198-6325, 1098-1128, 1098-1128
Online Access:Get full text
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Summary:Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide. Individuals with NAFLD have a high frequency of developing progressive liver disease and metabolism‐related comorbidities, which result from of a lack of awareness and poor surveillance of the disease and a paucity of approved and effective therapies. Managing the complications of NAFLD has already begun to place a tremendous burden on health‐care systems. Although efforts to identify effective therapies are underway, the lack of validated preclinical NAFLD models that represent the biology and outcomes of human disease remains a major barrier. This review summarizes the characteristics and prevalence of the disease and the status of our understanding of its mechanisms and potential therapeutic targets.
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ISSN:0198-6325
1098-1128
1098-1128
DOI:10.1002/med.21515