Progress and challenges in the prevention and control of nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide. Individuals with NAFLD have a high frequency of developing progressive liver disease and metabolism‐related comorbidities, which result from of a lack of awareness and poor surveillance of the disea...

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Vydáno v:Medicinal research reviews Ročník 39; číslo 1; s. 328 - 348
Hlavní autoři: Cai, Jingjing, Zhang, Xiao‐Jing, Li, Hongliang
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Wiley Subscription Services, Inc 01.01.2019
Témata:
animal model
awareness
Disease prevention
epidemiology
Fatty liver
Liver diseases
molecular target
nonalcoholic fatty liver disease (NAFLD)
epidemiology
nonalcoholic fatty liver disease (NAFLD)
awareness
animal model
molecular target
ISSN:0198-6325, 1098-1128, 1098-1128
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Shrnutí:Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide. Individuals with NAFLD have a high frequency of developing progressive liver disease and metabolism‐related comorbidities, which result from of a lack of awareness and poor surveillance of the disease and a paucity of approved and effective therapies. Managing the complications of NAFLD has already begun to place a tremendous burden on health‐care systems. Although efforts to identify effective therapies are underway, the lack of validated preclinical NAFLD models that represent the biology and outcomes of human disease remains a major barrier. This review summarizes the characteristics and prevalence of the disease and the status of our understanding of its mechanisms and potential therapeutic targets.
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ISSN:0198-6325
1098-1128
1098-1128
DOI:10.1002/med.21515