Dopamine drives binge‐like consumption of a palatable food in experimental Parkinsonism
Background Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be e...
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| Vydané v: | Movement disorders Ročník 34; číslo 6; s. 821 - 831 |
|---|---|
| Hlavní autori: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Hoboken, USA
John Wiley & Sons, Inc
01.06.2019
Wiley Subscription Services, Inc |
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| ISSN: | 0885-3185, 1531-8257, 1531-8257 |
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| Abstract | Background
Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals.
Objectives
We hypothesize that manipulation of dopamine levels in a 6‐hydroxydopamine–lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge‐like eating behavior.
Methods
Food preference, food intake, and weight gain were monitored in sham‐operated and unilaterally lesioned rats, subjected to a modified version of Corwin's limited access protocol, modelling binge eating disorder. Electrophysiological properties and long‐term potentiation of GABAergic spiny projection neurons of the nucleus accumbens core were studied through ex vivo intracellular and patch‐clamp recordings from corticostriatal slices of naïve and l‐dopa–treated rats.
Results
Sham‐operated animals with intact nucleus accumbens core plasticity reliably developed food‐addiction–like behavior when exposed to intermittent access to a highly palatable food. In contrast, parkinsonian rats were unresponsive to such restriction regimens, and also plasticity was lost in ventral spiny neurons. Chronic l‐dopa reestablished long‐term potentiation and compulsive eating, but with a different temporal dynamic that follows that of drug administration.
Conclusions
Our data indicate that endogenous and exogenous dopamine drive binge‐like consumption of a palatable food in healthy and parkinsonian rats with distinct temporal dynamics, providing new insights into the complexity of l‐dopa effects on the mesolimbic dopaminergic system. © 2019 International Parkinson and Movement Disorder Society |
|---|---|
| AbstractList | Background
Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals.
Objectives
We hypothesize that manipulation of dopamine levels in a 6‐hydroxydopamine–lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge‐like eating behavior.
Methods
Food preference, food intake, and weight gain were monitored in sham‐operated and unilaterally lesioned rats, subjected to a modified version of Corwin's limited access protocol, modelling binge eating disorder. Electrophysiological properties and long‐term potentiation of GABAergic spiny projection neurons of the nucleus accumbens core were studied through ex vivo intracellular and patch‐clamp recordings from corticostriatal slices of naïve and l‐dopa–treated rats.
Results
Sham‐operated animals with intact nucleus accumbens core plasticity reliably developed food‐addiction–like behavior when exposed to intermittent access to a highly palatable food. In contrast, parkinsonian rats were unresponsive to such restriction regimens, and also plasticity was lost in ventral spiny neurons. Chronic l‐dopa reestablished long‐term potentiation and compulsive eating, but with a different temporal dynamic that follows that of drug administration.
Conclusions
Our data indicate that endogenous and exogenous dopamine drive binge‐like consumption of a palatable food in healthy and parkinsonian rats with distinct temporal dynamics, providing new insights into the complexity of l‐dopa effects on the mesolimbic dopaminergic system. © 2019 International Parkinson and Movement Disorder Society Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals.BACKGROUNDProlonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals.We hypothesize that manipulation of dopamine levels in a 6-hydroxydopamine-lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge-like eating behavior.OBJECTIVESWe hypothesize that manipulation of dopamine levels in a 6-hydroxydopamine-lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge-like eating behavior.Food preference, food intake, and weight gain were monitored in sham-operated and unilaterally lesioned rats, subjected to a modified version of Corwin's limited access protocol, modelling binge eating disorder. Electrophysiological properties and long-term potentiation of GABAergic spiny projection neurons of the nucleus accumbens core were studied through ex vivo intracellular and patch-clamp recordings from corticostriatal slices of naïve and l-dopa-treated rats.METHODSFood preference, food intake, and weight gain were monitored in sham-operated and unilaterally lesioned rats, subjected to a modified version of Corwin's limited access protocol, modelling binge eating disorder. Electrophysiological properties and long-term potentiation of GABAergic spiny projection neurons of the nucleus accumbens core were studied through ex vivo intracellular and patch-clamp recordings from corticostriatal slices of naïve and l-dopa-treated rats.Sham-operated animals with intact nucleus accumbens core plasticity reliably developed food-addiction-like behavior when exposed to intermittent access to a highly palatable food. In contrast, parkinsonian rats were unresponsive to such restriction regimens, and also plasticity was lost in ventral spiny neurons. Chronic l-dopa reestablished long-term potentiation and compulsive eating, but with a different temporal dynamic that follows that of drug administration.RESULTSSham-operated animals with intact nucleus accumbens core plasticity reliably developed food-addiction-like behavior when exposed to intermittent access to a highly palatable food. In contrast, parkinsonian rats were unresponsive to such restriction regimens, and also plasticity was lost in ventral spiny neurons. Chronic l-dopa reestablished long-term potentiation and compulsive eating, but with a different temporal dynamic that follows that of drug administration.Our data indicate that endogenous and exogenous dopamine drive binge-like consumption of a palatable food in healthy and parkinsonian rats with distinct temporal dynamics, providing new insights into the complexity of l-dopa effects on the mesolimbic dopaminergic system. © 2019 International Parkinson and Movement Disorder Society.CONCLUSIONSOur data indicate that endogenous and exogenous dopamine drive binge-like consumption of a palatable food in healthy and parkinsonian rats with distinct temporal dynamics, providing new insights into the complexity of l-dopa effects on the mesolimbic dopaminergic system. © 2019 International Parkinson and Movement Disorder Society. Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals. We hypothesize that manipulation of dopamine levels in a 6-hydroxydopamine-lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge-like eating behavior. Food preference, food intake, and weight gain were monitored in sham-operated and unilaterally lesioned rats, subjected to a modified version of Corwin's limited access protocol, modelling binge eating disorder. Electrophysiological properties and long-term potentiation of GABAergic spiny projection neurons of the nucleus accumbens core were studied through ex vivo intracellular and patch-clamp recordings from corticostriatal slices of naïve and l-dopa-treated rats. Sham-operated animals with intact nucleus accumbens core plasticity reliably developed food-addiction-like behavior when exposed to intermittent access to a highly palatable food. In contrast, parkinsonian rats were unresponsive to such restriction regimens, and also plasticity was lost in ventral spiny neurons. Chronic l-dopa reestablished long-term potentiation and compulsive eating, but with a different temporal dynamic that follows that of drug administration. Our data indicate that endogenous and exogenous dopamine drive binge-like consumption of a palatable food in healthy and parkinsonian rats with distinct temporal dynamics, providing new insights into the complexity of l-dopa effects on the mesolimbic dopaminergic system. © 2019 International Parkinson and Movement Disorder Society. BackgroundProlonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals.ObjectivesWe hypothesize that manipulation of dopamine levels in a 6‐hydroxydopamine–lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge‐like eating behavior.MethodsFood preference, food intake, and weight gain were monitored in sham‐operated and unilaterally lesioned rats, subjected to a modified version of Corwin's limited access protocol, modelling binge eating disorder. Electrophysiological properties and long‐term potentiation of GABAergic spiny projection neurons of the nucleus accumbens core were studied through ex vivo intracellular and patch‐clamp recordings from corticostriatal slices of naïve and l‐dopa–treated rats.ResultsSham‐operated animals with intact nucleus accumbens core plasticity reliably developed food‐addiction–like behavior when exposed to intermittent access to a highly palatable food. In contrast, parkinsonian rats were unresponsive to such restriction regimens, and also plasticity was lost in ventral spiny neurons. Chronic l‐dopa reestablished long‐term potentiation and compulsive eating, but with a different temporal dynamic that follows that of drug administration.ConclusionsOur data indicate that endogenous and exogenous dopamine drive binge‐like consumption of a palatable food in healthy and parkinsonian rats with distinct temporal dynamics, providing new insights into the complexity of l‐dopa effects on the mesolimbic dopaminergic system. © 2019 International Parkinson and Movement Disorder Society |
| Author | Calabresi, Paolo Picconi, Barbara Campanelli, Federica Cacace, Fabrizio Marino, Gioia Mineo, Désirée Mancini, Maria Vannelli, Anna Ghiglieri, Veronica Natale, Giuseppina Cardinale, Antonella |
| Author_xml | – sequence: 1 givenname: Désirée surname: Mineo fullname: Mineo, Désirée organization: IRCCS Fondazione Santa Lucia – sequence: 2 givenname: Fabrizio surname: Cacace fullname: Cacace, Fabrizio organization: IRCCS Fondazione Santa Lucia – sequence: 3 givenname: Maria surname: Mancini fullname: Mancini, Maria organization: IRCCS Fondazione Santa Lucia – sequence: 4 givenname: Anna surname: Vannelli fullname: Vannelli, Anna organization: IRCCS Fondazione Santa Lucia – sequence: 5 givenname: Federica surname: Campanelli fullname: Campanelli, Federica organization: IRCCS Fondazione Santa Lucia – sequence: 6 givenname: Giuseppina surname: Natale fullname: Natale, Giuseppina organization: IRCCS Fondazione Santa Lucia – sequence: 7 givenname: Gioia surname: Marino fullname: Marino, Gioia organization: IRCCS Fondazione Santa Lucia – sequence: 8 givenname: Antonella surname: Cardinale fullname: Cardinale, Antonella organization: Università di Perugia – sequence: 9 givenname: Paolo surname: Calabresi fullname: Calabresi, Paolo organization: Università di Perugia – sequence: 10 givenname: Barbara surname: Picconi fullname: Picconi, Barbara organization: IRCCS San Raffaele Pisana e Università San Raffaele – sequence: 11 givenname: Veronica surname: Ghiglieri fullname: Ghiglieri, Veronica email: veronica.ghiglieri@unipg.it organization: Università di Perugia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31002748$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neuron.2008.07.004 10.1176/appi.books.9780890425596 10.1152/jn.1999.82.6.3575 10.1523/JNEUROSCI.22-11-04709.2002 10.1523/JNEUROSCI.6588-10.2011 10.1038/nn1040 10.1007/BF00589894 10.1038/nn1429 10.1016/S0031-9384(98)00201-7 10.1056/NEJM196907312810517 10.1016/S0002-8223(99)00307-7 10.3389/fnbeh.2016.00054 10.1523/JNEUROSCI.6491-10.2011 10.1093/scan/nst059 10.1523/JNEUROSCI.3958-10.2010 10.1038/nn1713 10.1007/978-3-7091-0932-8_24 10.1016/S1474-4422(09)70287-X 10.1038/nrn2234 10.1093/ilar.53.1.23 10.1002/0471142301.ns0923bs36 10.1016/j.appet.2010.09.010 10.1016/j.nbd.2015.11.022 10.1016/j.biopsych.2015.08.013 10.1016/j.neubiorev.2013.02.010 10.1016/S1474-4422(17)30004-2 10.1002/oby.21626 10.1002/mds.27181 10.1093/ajcn/69.6.1264 10.1113/jphysiol.2009.172759 10.1002/mds.26121 10.1098/rstb.2002.1236 10.1016/j.appet.2003.08.010 10.1016/j.nbd.2007.10.001 10.1038/382677a0 10.1523/JNEUROSCI.2344-15.2015 |
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| References | 2015; 35 2010; 55 2004; 42 2003; 358 2015; 30 2006; 9 1999; 69 2011; 31 2016; 10 1996; 382 2008; 59 2006 2005 1999; 82 1998; 65 2012; 53 2016; 79 1969; 281 1989; 99 2013; 37 2012; 970 2017; 16 2003; 6 2008; 29 2017; 32 2005; 8 2002; 22 2007; 8 2016; 86 1999; 99 2009; 8 2013 2014; 9 2014; 8 2010; 30 2009; 587 2016; 24 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_26_1 e_1_2_7_28_1 e_1_2_7_29_1 Paxinos G (e_1_2_7_21_1) 2005 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_35_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_37_1 e_1_2_7_38_1 e_1_2_7_39_1 De Luca MA (e_1_2_7_27_1) 2014; 8 |
| References_xml | – volume: 358 start-page: 815 year: 2003 end-page: 819 article-title: Synaptic plasticity in the mesolimbic dopamine system publication-title: Philos Trans R Soc Lond B Biol Sci – year: 2005 – volume: 970 start-page: 553 year: 2012 end-page: 572 article-title: Synaptic dysfunction in Parkinson's disease publication-title: Adv Exp Med Biol – year: 2006 article-title: Binge eating in rats with limited access to vegetable shortening publication-title: Curr Protoc Neurosci – volume: 6 start-page: 501 year: 2003 end-page: 506 article-title: Loss of bidirectional striatal synaptic plasticity in L‐DOPA‐induced dyskinesia publication-title: Nat Neurosci – volume: 99 start-page: 473 year: 1989 end-page: 478 article-title: Nicotine maintains robust self‐administration in rats on a limited‐access schedule publication-title: Psychopharmacology (Berl) – volume: 86 start-page: 140 year: 2016 end-page: 153 article-title: Modulation of serotonergic transmission by eltoprazine in L‐DOPA‐induced dyskinesia: behavioral, molecular, and synaptic mechanisms publication-title: Neurobiol Dis – volume: 587 start-page: 4405 issue: Pt 18 year: 2009 end-page: 4423 article-title: The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico‐subthalamic nucleus‐globus pallidus pathway publication-title: J Physiol – volume: 32 start-page: 1557 year: 2017 end-page: 1565 article-title: Impulse control disorders in advanced Parkinson's disease with dyskinesia: the ALTHEA study publication-title: Mov Disord – volume: 22 start-page: 4709 year: 2002 end-page: 4719 article-title: Differential expression of motivational stimulus properties by dopamine in nucleus accumbens shell versus core and prefrontal cortex publication-title: J Neurosci – volume: 29 start-page: 327 year: 2008 end-page: 335 article-title: l‐DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation publication-title: Neurobiol Dis – volume: 8 start-page: 484 year: 2005 end-page: 489 article-title: The subthalamic nucleus exerts opposite control on cocaine and ‘natural’ rewards publication-title: Nat Neurosci – volume: 281 start-page: 272 year: 1969 article-title: L‐dopa in Parkinson's syndrome publication-title: N Engl J Med – volume: 30 start-page: 90 year: 2015 end-page: 102 article-title: Behavioral effects of levodopa publication-title: Mov Disord – volume: 16 start-page: 238 year: 2017 end-page: 250 article-title: Impulse control disorders and levodopa‐induced dyskinesias in Parkinson's disease: an update publication-title: Lancet Neurol – volume: 31 start-page: 6820 year: 2011 end-page: 6830 article-title: Roles of nucleus accumbens core and shell in incentive‐cue responding and behavioral inhibition publication-title: J Neurosci – volume: 79 start-page: 402 year: 2016 end-page: 414 article-title: Alpha‐synuclein produces early behavioral alterations via striatal cholinergic synaptic dysfunction by interacting with GluN2D N‐methyl‐D‐aspartate receptor subunit publication-title: Biol Psychiatry – volume: 9 start-page: 932 year: 2014 end-page: 938 article-title: Relation of obesity to neural activation in response to food commercials publication-title: Soc Cogn Affect Neurosci – volume: 8 start-page: 844 year: 2007 end-page: 858 article-title: Synaptic plasticity and addiction publication-title: Nat Rev Neurosci – volume: 31 start-page: 6001 year: 2011 end-page: 6007 article-title: Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing publication-title: J Neurosci – volume: 69 start-page: 1264 year: 1999 end-page: 1272 article-title: Restricting access to palatable foods affects children's behavioral response, food selection, and intake publication-title: Am J Clin Nutr – volume: 99 start-page: 1249 year: 1999 end-page: 1256 article-title: Chocolate: food or drug? publication-title: J Am Diet Assoc – volume: 59 start-page: 648 year: 2008 end-page: 661 article-title: Basolateral amygdala neurons facilitate reward‐seeking behavior by exciting nucleus accumbens neurons publication-title: Neuron – volume: 8 start-page: 21 year: 2014 article-title: Habituation of the responsiveness of mesolimbic and mesocortical dopamine transmission to taste stimuli publication-title: Front Integr Neurosci – volume: 53 start-page: 23 year: 2012 end-page: 34 article-title: Rodent models of binge eating: are they models of addiction? publication-title: ILAR J – volume: 10 start-page: 54 year: 2016 article-title: Prolonged consumption of sucrose in a binge‐like manner, alters the morphology of medium spiny neurons in the nucleus accumbens shell publication-title: Front Behav Neurosci – volume: 24 start-page: 2118 year: 2016 end-page: 2125 article-title: Binge‐type eating disrupts dopaminergic and GABAergic signaling in the prefrontal cortex and ventral tegmental area publication-title: Obesity – volume: 30 start-page: 16585 year: 2010 end-page: 16600 article-title: The flexible approach hypothesis: unification of effort and cue‐responding hypotheses for the role of nucleus accumbens dopamine in the activation of reward‐seeking behavior publication-title: J Neurosci – volume: 35 start-page: 11572 year: 2015 end-page: 11582 article-title: Differential dopamine release dynamics in the nucleus accumbens core and shell reveal complementary signals for error prediction and incentive motivation publication-title: J Neurosci – volume: 42 start-page: 139 year: 2004 end-page: 142 article-title: Binge‐type eating induced by limited access in rats does not require energy restriction on the previous day publication-title: Appetite – volume: 82 start-page: 3575 year: 1999 end-page: 3579 article-title: Unilateral dopamine denervation blocks corticostriatal LTP publication-title: J Neurophysiol – volume: 8 start-page: 1140 year: 2009 end-page: 1149 article-title: Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders publication-title: Lancet Neurol – volume: 9 start-page: 868 year: 2006 end-page: 869 article-title: Cocaine self‐administration selectively abolishes LTD in the core of the nucleus accumbens publication-title: Nat Neurosci – volume: 382 start-page: 677 year: 1996 end-page: 678 article-title: Brain cannabinoids in chocolate publication-title: Nature – volume: 37 start-page: 1946 issue: 9 Pt A year: 2013 end-page: 1954 article-title: From the ventral to the dorsal striatum: devolving views of their roles in drug addiction publication-title: Neurosci Biobehav Rev – volume: 65 start-page: 545 year: 1998 end-page: 553 article-title: Limited access to a dietary fat option affects ingestive behavior but not body composition in male rats publication-title: Physiol Behav – year: 2013 – volume: 55 start-page: 734 year: 2010 end-page: 737 article-title: The study of food addiction using animal models of binge eating publication-title: Appetite – ident: e_1_2_7_8_1 doi: 10.1016/j.neuron.2008.07.004 – ident: e_1_2_7_12_1 doi: 10.1176/appi.books.9780890425596 – ident: e_1_2_7_22_1 doi: 10.1152/jn.1999.82.6.3575 – ident: e_1_2_7_5_1 doi: 10.1523/JNEUROSCI.22-11-04709.2002 – ident: e_1_2_7_6_1 doi: 10.1523/JNEUROSCI.6588-10.2011 – ident: e_1_2_7_20_1 doi: 10.1038/nn1040 – ident: e_1_2_7_25_1 doi: 10.1007/BF00589894 – ident: e_1_2_7_36_1 doi: 10.1038/nn1429 – ident: e_1_2_7_15_1 doi: 10.1016/S0031-9384(98)00201-7 – ident: e_1_2_7_2_1 doi: 10.1056/NEJM196907312810517 – ident: e_1_2_7_26_1 doi: 10.1016/S0002-8223(99)00307-7 – ident: e_1_2_7_17_1 doi: 10.3389/fnbeh.2016.00054 – ident: e_1_2_7_10_1 doi: 10.1523/JNEUROSCI.6491-10.2011 – volume: 8 start-page: 21 year: 2014 ident: e_1_2_7_27_1 article-title: Habituation of the responsiveness of mesolimbic and mesocortical dopamine transmission to taste stimuli publication-title: Front Integr Neurosci – ident: e_1_2_7_13_1 doi: 10.1093/scan/nst059 – ident: e_1_2_7_9_1 doi: 10.1523/JNEUROSCI.3958-10.2010 – ident: e_1_2_7_18_1 doi: 10.1038/nn1713 – ident: e_1_2_7_30_1 doi: 10.1007/978-3-7091-0932-8_24 – ident: e_1_2_7_3_1 doi: 10.1016/S1474-4422(09)70287-X – ident: e_1_2_7_4_1 doi: 10.1038/nrn2234 – ident: e_1_2_7_32_1 doi: 10.1093/ilar.53.1.23 – ident: e_1_2_7_16_1 doi: 10.1002/0471142301.ns0923bs36 – ident: e_1_2_7_14_1 doi: 10.1016/j.appet.2010.09.010 – ident: e_1_2_7_19_1 doi: 10.1016/j.nbd.2015.11.022 – ident: e_1_2_7_35_1 doi: 10.1016/j.biopsych.2015.08.013 – ident: e_1_2_7_33_1 doi: 10.1016/j.neubiorev.2013.02.010 – ident: e_1_2_7_31_1 doi: 10.1016/S1474-4422(17)30004-2 – ident: e_1_2_7_39_1 doi: 10.1002/oby.21626 – ident: e_1_2_7_29_1 doi: 10.1002/mds.27181 – volume-title: The Rat Brain in Stereotaxic Coordinates. Amsterdam year: 2005 ident: e_1_2_7_21_1 – ident: e_1_2_7_24_1 doi: 10.1093/ajcn/69.6.1264 – ident: e_1_2_7_37_1 doi: 10.1113/jphysiol.2009.172759 – ident: e_1_2_7_11_1 doi: 10.1002/mds.26121 – ident: e_1_2_7_34_1 doi: 10.1098/rstb.2002.1236 – ident: e_1_2_7_38_1 doi: 10.1016/j.appet.2003.08.010 – ident: e_1_2_7_23_1 doi: 10.1016/j.nbd.2007.10.001 – ident: e_1_2_7_28_1 doi: 10.1038/382677a0 – ident: e_1_2_7_7_1 doi: 10.1523/JNEUROSCI.2344-15.2015 |
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Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing... Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off,... BackgroundProlonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing... |
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| SubjectTerms | Addictions Animal behavior Animals Basal ganglia Behavioral plasticity Binge eating Body weight gain Brain diseases Central nervous system diseases Cortex Denervation Dihydroxyphenylalanine Dopamine Dopamine Agents - pharmacology Dopamine receptors Eating - drug effects Eating disorders Feeding Behavior - drug effects Food Food intake Food preferences Food Preferences - drug effects impulse control disorders Impulsive behavior Laboratory animals Levodopa Levodopa - pharmacology Long-Term Potentiation - drug effects l‐dopa Male Mesolimbic system Movement disorders Neostriatum Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - physiopathology Oxidopamine Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - physiopathology plasticity Potentiation Rats Rats, Wistar Rodents Spiny neurons Synaptic plasticity Weight Gain - drug effects |
| Title | Dopamine drives binge‐like consumption of a palatable food in experimental Parkinsonism |
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