Dopamine drives binge‐like consumption of a palatable food in experimental Parkinsonism

Background Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be e...

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Published in:Movement disorders Vol. 34; no. 6; pp. 821 - 831
Main Authors: Mineo, Désirée, Cacace, Fabrizio, Mancini, Maria, Vannelli, Anna, Campanelli, Federica, Natale, Giuseppina, Marino, Gioia, Cardinale, Antonella, Calabresi, Paolo, Picconi, Barbara, Ghiglieri, Veronica
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.06.2019
Wiley Subscription Services, Inc
Subjects:
Addictions
Animal behavior
Animals
Basal ganglia
Behavioral plasticity
Binge eating
Body weight gain
Brain diseases
Central nervous system diseases
Cortex
Denervation
Dihydroxyphenylalanine
Dopamine
Dopamine Agents - pharmacology
Dopamine receptors
Eating - drug effects
Eating disorders
Feeding Behavior - drug effects
Food
Food intake
Food preferences
Food Preferences - drug effects
impulse control disorders
Impulsive behavior
Laboratory animals
Levodopa
Levodopa - pharmacology
Long-Term Potentiation - drug effects
l‐dopa
Male
Mesolimbic system
Movement disorders
Neostriatum
Nucleus accumbens
Nucleus Accumbens - drug effects
Nucleus Accumbens - physiopathology
Oxidopamine
Parkinson's disease
Parkinsonian Disorders - chemically induced
Parkinsonian Disorders - physiopathology
plasticity
Potentiation
Rats
Rats, Wistar
Rodents
Spiny neurons
Synaptic plasticity
Weight Gain - drug effects
impulse control disorders
l-dopa
plasticity
nucleus accumbens
ISSN:0885-3185, 1531-8257, 1531-8257
Online Access:Get full text
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Summary:Background Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals. Objectives We hypothesize that manipulation of dopamine levels in a 6‐hydroxydopamine–lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge‐like eating behavior. Methods Food preference, food intake, and weight gain were monitored in sham‐operated and unilaterally lesioned rats, subjected to a modified version of Corwin's limited access protocol, modelling binge eating disorder. Electrophysiological properties and long‐term potentiation of GABAergic spiny projection neurons of the nucleus accumbens core were studied through ex vivo intracellular and patch‐clamp recordings from corticostriatal slices of naïve and l‐dopa–treated rats. Results Sham‐operated animals with intact nucleus accumbens core plasticity reliably developed food‐addiction–like behavior when exposed to intermittent access to a highly palatable food. In contrast, parkinsonian rats were unresponsive to such restriction regimens, and also plasticity was lost in ventral spiny neurons. Chronic l‐dopa reestablished long‐term potentiation and compulsive eating, but with a different temporal dynamic that follows that of drug administration. Conclusions Our data indicate that endogenous and exogenous dopamine drive binge‐like consumption of a palatable food in healthy and parkinsonian rats with distinct temporal dynamics, providing new insights into the complexity of l‐dopa effects on the mesolimbic dopaminergic system. © 2019 International Parkinson and Movement Disorder Society
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ISSN:0885-3185
1531-8257
1531-8257
DOI:10.1002/mds.27683