Association of antiviral drugs and their possible mechanisms with DRESS syndrome using data mining algorithms

Antiviral drugs are not known for drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. The current study aims is to find out the association of antiviral drugs and their possible mechanism with DRESS. Data mining algorithms such as proportional reporting ratio that is, PRR (≥2) wi...

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Bibliographic Details
Published in:Journal of medical virology Vol. 95; no. 3; pp. e28671 - n/a
Main Authors: Sharma, Akash, Roy, Sweta, Sharma, Ruchika, Kumar, Anoop
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.03.2023
Subjects:
Abacavir
Acyclovir
Algorithms
Allergies
Antigens
Antiretroviral drugs
Antiviral agents
Antiviral Agents - adverse effects
Antiviral drugs
Data Mining
data mining algorithms
docking study
DRESS
Drug Hypersensitivity Syndrome - etiology
Drug interaction
Drugs
Eosinophilia
Exanthema
Ganciclovir
Histocompatibility antigen HLA
Histocompatibility Antigens Class I
HLA Antigens
Humans
Lamivudine
Lopinavir
Molecular docking
Molecular Docking Simulation
Nevirapine
Ribavirin
Ritonavir
Sensitivity analysis
Side effects
Subgroups
Virology
Zidovudine
antiviral drugs
DRESS
docking study
data mining algorithms
ISSN:0146-6615, 1096-9071, 1096-9071
Online Access:Get full text
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Summary:Antiviral drugs are not known for drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. The current study aims is to find out the association of antiviral drugs and their possible mechanism with DRESS. Data mining algorithms such as proportional reporting ratio that is, PRR (≥2) with associated χ2 value (>4), reporting odds ratio that is, ROR (≥2) with 95% confidence interval and case count (≥3) were calculated to identify a possible signal. Further, molecular docking studies were conducted to check the interaction of selected antiviral drugs with possible targets. The potential signal of DRESS was found to be associated with abacavir, acyclovir, ganciclovir, lamivudine, lopinavir, nevirapine, ribavirin, ritonavir, and zidovudine among all selected antiviral drugs. Further, subgroup analysis has also shown a potential signal in different age groups and gender. The sensitivity analysis results have shown a decrease in the strength of the signal, however, there was no significant impact on the outcome except for acyclovir. The docking results have indicated the possible involvement of human leukocyte antigen (HLA)*B1502 and HLA*B5801. The positive signal of DRESS was found with selected antiviral drugs except for acyclovir.
Bibliography:Akash Sharma and Sweta Roy contributed equally to this work.
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ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.28671