Major depressive disorder

Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and physical and cognitive symptoms. People with MDD can have reduced quality of life owing to the disorder itself as well as r...

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Bibliographic Details
Published in:Nature reviews. Disease primers Vol. 9; no. 1; p. 44
Main Authors: Marx, Wolfgang, Penninx, Brenda W. J. H., Solmi, Marco, Furukawa, Toshi A., Firth, Joseph, Carvalho, Andre F., Berk, Michael
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 24.08.2023
Nature Publishing Group
Subjects:
692/420
692/499
692/699/476/1414
692/700/565
Cancer Research
Epidemiology
Internal Medicine
Medical Microbiology
Medicine
Medicine & Public Health
Mental depression
Primer
Quality of life
Quality of Life Research
ISSN:2056-676X, 2056-676X
Online Access:Get full text
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Summary:Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and physical and cognitive symptoms. People with MDD can have reduced quality of life owing to the disorder itself as well as related medical comorbidities, social factors, and impaired functional outcomes. MDD is a complex disorder that cannot be fully explained by any one single established biological or environmental pathway. Instead, MDD seems to be caused by a combination of genetic, environmental, psychological and biological factors. Treatment for MDD commonly involves pharmacological therapy with antidepressant medications, psychotherapy or a combination of both. In people with severe and/or treatment-resistant MDD, other biological therapies, such as electroconvulsive therapy, may also be offered. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of major depressive disorder (MDD). This Primer also reviews how this disorder affects patient quality of life, and provides an overview of future research.
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ISSN:2056-676X
2056-676X
DOI:10.1038/s41572-023-00454-1