Bioprosthetic Total Artificial Heart Implantation Does Not Induce Chronic Inflammation

The Aeson total artificial heart (A-TAH) has been developed for patients at risk of death from biventricular failure. We aimed to assess the inflammatory status in nine subjects implanted with the A-TAH in kinetics over one year. Laboratory assessment of leukocyte counts, inflammatory cytokines assa...

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Veröffentlicht in:ASAIO journal (1992) Jg. 68; H. 11; S. e173
Hauptverfasser: Peronino, Christophe, Guerin, Coralie L, Ivak, Peter, Guyonnet, Léa, Chocron, Richard, Detriché, Grégoire, Latremouille, Christian, Gruest, Maxime, Philippe, Aurélien, Capel, Antoine, Pya, Yuri, Martin, Anne-Céline, Jansen, Piet, Gendron, Nicolas, Netuka, Ivan, Smadja, David M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.11.2022
Schlagworte:
Cytokines
Heart Failure - surgery
Heart Transplantation - adverse effects
Heart, Artificial - adverse effects
Humans
Inflammation - etiology
Leukocytes, Mononuclear
ISSN:1538-943X, 1538-943X
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Zusammenfassung:The Aeson total artificial heart (A-TAH) has been developed for patients at risk of death from biventricular failure. We aimed to assess the inflammatory status in nine subjects implanted with the A-TAH in kinetics over one year. Laboratory assessment of leukocyte counts, inflammatory cytokines assay, and peripheral blood mononuclear cell collection before and after A-TAH implantation. Leukocyte counts were not significantly modulated according to time after A-TAH implantation (coefficient of the linear mixed effect model with 95% CI, -0.05 (-0.71 to -0.61); p = 0.44). We explored inflammatory cytokine after A-TAH and did not observe, at any time, a modified profile compared to pre-implantation values (all p -values > 0.05). Finally, we compared the distribution of circulating immune cell subpopulations identified based on sequential expression patterns for multiple clusters of differentiation. None of the population explored had significant modulation during the 12-month follow-up (all p -values > 0.05). In conclusion, using a cytokine multiplex assay combined with a flow cytometry approach, we demonstrated the absence of inflammatory signals in peripheral blood over a period of 12 months following A-TAH implantation.
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ISSN:1538-943X
1538-943X
DOI:10.1097/MAT.0000000000001820