A UPLC-MS-MS method for the simultaneous quantification of first-line antituberculars in plasma and in PBMCs

TB is currently the second cause of death among patients affected with infectious diseases. Quantification of drug levels in plasma and in cells where Mycobacterium tuberculosis persists and grows may be useful in understanding the appropriateness of dosage regimens. We report a new and fully valida...

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Bibliographic Details
Published in:	Journal of antimicrobial chemotherapy Vol. 70; no. 9; p. 2572
Main Authors:	Baietto, Lorena, Calcagno, Andrea, Motta, Ilaria, Baruffi, Katia, Poretti, Viviana, Di Perri, Giovanni, Bonora, Stefano, D'Avolio, Antonio
Format:	Journal Article
Language:	English
Published:	England 01.09.2015
Subjects:	Adult Aged Aged, 80 and over Antitubercular Agents - administration & dosage Antitubercular Agents - pharmacokinetics Chromatography, Liquid Drug Monitoring Female Humans Leukocytes, Mononuclear - chemistry Male Middle Aged Plasma - chemistry Tandem Mass Spectrometry Tuberculosis - drug therapy Young Adult peripheral blood mononuclear cells rifampicin isoniazid ethambutol pyrazinamide determination TDM HPLC therapeutic drug monitoring
ISSN:	1460-2091, 1460-2091
Online Access:	Get more information
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