The Magic of Randomization versus the Myth of Real-World Evidence

Nonrandomized observational analyses have been promoted as alternatives to randomized clinical trials. However, randomization ensures balance between groups, whereas nonrandomized studies are often biased by between-group differences. Efforts to reduce the cost and complexity of clinical trials are...

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Vydáno v:The New England journal of medicine Ročník 382; číslo 7; s. 674 - 678
Hlavní autoři: Collins, Rory, Bowman, Louise, Landray, Martin, Peto, Richard
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Massachusetts Medical Society 13.02.2020
Témata:
Cancer therapies
Clinical trials
Humans
Observational Studies as Topic
Patient Selection
Patients
Quality Assurance, Health Care
Randomized Controlled Trials as Topic - economics
Randomized Controlled Trials as Topic - standards
Research methodology
Statins
ISSN:0028-4793, 1533-4406, 1533-4406
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Shrnutí:Nonrandomized observational analyses have been promoted as alternatives to randomized clinical trials. However, randomization ensures balance between groups, whereas nonrandomized studies are often biased by between-group differences. Efforts to reduce the cost and complexity of clinical trials are preferable to relying on observational studies.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMsb1901642