The Magic of Randomization versus the Myth of Real-World Evidence

Nonrandomized observational analyses have been promoted as alternatives to randomized clinical trials. However, randomization ensures balance between groups, whereas nonrandomized studies are often biased by between-group differences. Efforts to reduce the cost and complexity of clinical trials are...

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Veröffentlicht in:The New England journal of medicine Jg. 382; H. 7; S. 674 - 678
Hauptverfasser: Collins, Rory, Bowman, Louise, Landray, Martin, Peto, Richard
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Massachusetts Medical Society 13.02.2020
Schlagworte:
Cancer therapies
Clinical trials
Humans
Observational Studies as Topic
Patient Selection
Patients
Quality Assurance, Health Care
Randomized Controlled Trials as Topic - economics
Randomized Controlled Trials as Topic - standards
Research methodology
Statins
ISSN:0028-4793, 1533-4406, 1533-4406
Online-Zugang:Volltext
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Zusammenfassung:Nonrandomized observational analyses have been promoted as alternatives to randomized clinical trials. However, randomization ensures balance between groups, whereas nonrandomized studies are often biased by between-group differences. Efforts to reduce the cost and complexity of clinical trials are preferable to relying on observational studies.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMsb1901642