Network Classification Based on Reducibility With Respect to the Stability of Canalizing Power of Genes in a Gene Regulatory Network - A Boolean Network Modeling Perspective

A key objective of studying biological systems is to design therapeutic intervention strategies for beneficially altering cell dynamics. Derivation of control policies is hindered by the high-dimensional state spaces associated with gene regulatory networks. Hence, it is critical to reduce the netwo...

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Bibliographic Details
Published in:	IEEE/ACM transactions on computational biology and bioinformatics Vol. 19; no. 1; pp. 558 - 568
Main Authors:	Kim, Eunji, Ivanov, Ivan, Dougherty, Edward R.
Format:	Journal Article
Language:	English
Published:	United States IEEE 01.01.2022 The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:	Boolean Boolean algebra Boolean functions Canalizing power Complexity theory Computational modeling Electric power distribution External stimuli gene regulatory network Gene Regulatory Networks - genetics Genes Irrigation Models, Genetic network classification network reduction Networks Perturbation Perturbation methods Robustness Stability analysis
ISSN:	1545-5963, 1557-9964, 1557-9964
Online Access:	Get full text
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