A 90‐day toxicity study of tripeptide, arginine‐alanine‐lysine

There is a growing global interest in using peptides in the health industry for pharmaceuticals, cosmetics, and natural food products. Peptides contain two or more linked amino acids, whereas more than 50 amino acids are classified as polypeptides. Although there is a growing level of interest in th...

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Vydáno v:Journal of applied toxicology Ročník 43; číslo 9; s. 1332 - 1346
Hlavní autoři: Dunn, Maureen, Glávits, Róbert, Murbach, Timothy S., Modica, Vickie, Endres, John R., Hirka, Gábor, Pasics Szakonyiné, Ilona
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Wiley Subscription Services, Inc 01.09.2023
Témata:
Alanine
Amino acids
arginine
Cosmetics
Diet
Lysine
Natural & organic foods
NOAEL
peptide
Peptides
Polypeptides
RAK
safety
Toxicity
tripeptide
lysine
toxicity
peptide
arginine
safety
tripeptide
NOAEL
alanine
RAK
ISSN:0260-437X, 1099-1263, 1099-1263
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Shrnutí:There is a growing global interest in using peptides in the health industry for pharmaceuticals, cosmetics, and natural food products. Peptides contain two or more linked amino acids, whereas more than 50 amino acids are classified as polypeptides. Although there is a growing level of interest in the use of peptides in the health and wellness industry, there is a lack of literature pertaining to a specific tripeptide derived from arginine, alanine, and lysine (RAK) that is of interest for human dietary use. Therefore, a 90‐day repeated‐dose toxicity study was performed in rats to evaluate the subchronic oral toxicity of RAK. Eighty Han:WIST rats were administered RAK by gavage at doses of 0, 250, 500, or 1000 mg/kg bw/day. There were no mortalities or other treatment related effects, and no target organs were identified. A no‐observed‐adverse‐effect‐level (NOAEL) of 1000 mg/kg bw/day, the highest dose tested, was determined. This study will contribute to the body of research in regard to the safety of the use of RAK. There is a growing global interest in using peptides in the natural health industry; however, there is a lack of literature pertaining to a specific tripeptide, derived from arginine, alanine, and lysine (RAK). Therefore, a 90‐day repeated‐dose toxicity study was performed to evaluate the safety of RAK. A no‐observed‐adverse‐effect level in Han:WIST rats was 1000 mg/kg bw/day, the highest dose tested.
Bibliografie:Funding information
The authors disclose that financial support for the research described herein was provided by Lean Life Sciences, INC.
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ISSN:0260-437X
1099-1263
1099-1263
DOI:10.1002/jat.4468