A 90‐day toxicity study of tripeptide, arginine‐alanine‐lysine

There is a growing global interest in using peptides in the health industry for pharmaceuticals, cosmetics, and natural food products. Peptides contain two or more linked amino acids, whereas more than 50 amino acids are classified as polypeptides. Although there is a growing level of interest in th...

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Veröffentlicht in:	Journal of applied toxicology Jg. 43; H. 9; S. 1332 - 1346
Hauptverfasser:	Dunn, Maureen, Glávits, Róbert, Murbach, Timothy S., Modica, Vickie, Endres, John R., Hirka, Gábor, Pasics Szakonyiné, Ilona
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Wiley Subscription Services, Inc 01.09.2023
Schlagworte:	Alanine Amino acids arginine Cosmetics Diet Lysine Natural & organic foods NOAEL peptide Peptides Polypeptides RAK safety Toxicity tripeptide lysine toxicity peptide arginine safety tripeptide NOAEL alanine RAK
ISSN:	0260-437X, 1099-1263, 1099-1263
Online-Zugang:	Volltext
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Zusammenfassung:	There is a growing global interest in using peptides in the health industry for pharmaceuticals, cosmetics, and natural food products. Peptides contain two or more linked amino acids, whereas more than 50 amino acids are classified as polypeptides. Although there is a growing level of interest in the use of peptides in the health and wellness industry, there is a lack of literature pertaining to a specific tripeptide derived from arginine, alanine, and lysine (RAK) that is of interest for human dietary use. Therefore, a 90‐day repeated‐dose toxicity study was performed in rats to evaluate the subchronic oral toxicity of RAK. Eighty Han:WIST rats were administered RAK by gavage at doses of 0, 250, 500, or 1000 mg/kg bw/day. There were no mortalities or other treatment related effects, and no target organs were identified. A no‐observed‐adverse‐effect‐level (NOAEL) of 1000 mg/kg bw/day, the highest dose tested, was determined. This study will contribute to the body of research in regard to the safety of the use of RAK. There is a growing global interest in using peptides in the natural health industry; however, there is a lack of literature pertaining to a specific tripeptide, derived from arginine, alanine, and lysine (RAK). Therefore, a 90‐day repeated‐dose toxicity study was performed to evaluate the safety of RAK. A no‐observed‐adverse‐effect level in Han:WIST rats was 1000 mg/kg bw/day, the highest dose tested.
Bibliographie:	Funding information The authors disclose that financial support for the research described herein was provided by Lean Life Sciences, INC. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0260-437X 1099-1263 1099-1263
DOI:	10.1002/jat.4468