A multiscale absorption and transit model for oral delivery of hydroxychloroquine: Pharmacokinetic modeling and intestinal concentration prediction to assess toxicity and drug‐induced damage in healthy subjects

Hydroxychloroquine (HCQ) is commonly used in the treatment of malaria and rheumatic diseases. Recently it has also been identified as possible therapeutic option in combating COVID‐19. However, the use of HCQ is known to induce cytotoxicity. In 2020, we developed a multiscale absorption and transit...

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Veröffentlicht in:	International journal for numerical methods in biomedical engineering Jg. 36; H. 12; S. e3403 - n/a
Hauptverfasser:	Kannan, Ravishekar, Przekwas, Andrzej
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Hoboken, USA John Wiley & Sons, Inc 01.12.2020 Wiley Subscription Services, Inc
Schlagworte:	Absorption Administration, Oral Bioavailability CC50 Computer applications Computer Simulation COVID-19 COVID-19 - drug therapy COVID-19 - metabolism COVID-19 - pathology Cytotoxicity Damage Data integration Dissolution Duodenum gastrointestinal tract GIT HCQ Healthy Volunteers Humans Hydroxychloroquine Hydroxychloroquine - adverse effects Hydroxychloroquine - pharmacokinetics Hydroxychloroquine - therapeutic use Intestine Malaria MAT Medical treatment Metabolism Models, Biological multiscale multiscale absorption and transit Optimization Oral administration Pharmacokinetics Pharmacology quasi‐3D (Q3D) Rheumatic diseases SARS-CoV-2 Stomach Toolkits Toxicity Vector-borne diseases COVID-19 MAT GIT gastrointestinal tract CC50 multiscale absorption and transit HCQ quasi-3D (Q3D) multiscale cytotoxicity
ISSN:	2040-7939, 2040-7947, 2040-7947
Online-Zugang:	Volltext
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