Recent progress of atmospheric and room‐temperature plasma as a new and promising mutagenesis technology

At present, atmospheric and room‐temperature plasma (ARTP) is regarded as a new and powerful mutagenesis technology with the advantages of environment‐friendliness, operation under mild conditions, and fast mutagenesis speed. Compared with traditional mutagenesis strategies, ARTP is used mainly to c...

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Veröffentlicht in:Cell biochemistry and function Jg. 42; H. 3; S. e3991 - n/a
Hauptverfasser: Li, Dongao, Shen, Jie, Ding, Qiang, Wu, Jinyong, Chen, Xiangsong
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Wiley Subscription Services, Inc 01.04.2024
Schlagworte:
atmospheric and room‐temperature plasma
Deoxyribonucleic acid
DNA
DNA Damage
DNA structure
Microbiology
Microorganisms
Mutagenesis
mutagenesis breeding
mutagenic mechanism
Nucleotides
screening technology
Temperature
Temperature inversions
mutagenic mechanism
atmospheric and room‐temperature plasma
screening technology
microorganisms
mutagenesis breeding
ISSN:0263-6484, 1099-0844, 1099-0844
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Zusammenfassung:At present, atmospheric and room‐temperature plasma (ARTP) is regarded as a new and powerful mutagenesis technology with the advantages of environment‐friendliness, operation under mild conditions, and fast mutagenesis speed. Compared with traditional mutagenesis strategies, ARTP is used mainly to change the structure of microbial DNA, enzymes, and proteins through a series of physical, chemical, and electromagnetic effects with the organisms, leading to nucleotide breakage, conversion or inversion, causing various DNA damages, so as to screen out the microbial mutants with better biological characteristics. As a result, in recent years, ARTP mutagenesis and the combination of ARTP with traditional mutagenesis have been widely used in microbiology, showing great potential for application. In this review, the recent progress of ARTP mutagenesis in different application fields and bottlenecks of this technology are systematically summarized, with a view to providing a theoretical basis and technical support for better application. Finally, the outlook of ARTP mutagenesis is presented, and we identify the challenges in the field of microbial mutagenesis by ARTP. Significance statement The aim of this review is to analyze the beneficial mutagenic effects induced by ARTP on microbial cells and the related mutagenic mechanisms. Subsequently, bottleneck issues and the recent research progress of ARTP on mutagenesis are systematically summarized, and the application prospect is presented. This review may provide valuable insights and research ideas for future atmospheric and room‐temperature plasma mutagenesis of cells.
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ISSN:0263-6484
1099-0844
1099-0844
DOI:10.1002/cbf.3991