Targeting the NPY/NPY1R signaling axis in mutant p53–dependent pancreatic cancer impairs metastasis

Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known for its role in controlling energy homeostasis, has also been shown to promote tumorig...

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Published in:	Science advances Vol. 11; no. 11; p. eadq4416
Main Authors:	Chambers, Cecilia R., Watakul, Supitchaya, Schofield, Peter, Howell, Anna E., Zhu, Jessie, Tran, Alice M. H., Kuepper, Nadia, Reed, Daniel A., Murphy, Kendelle J., Channon, Lily M., Pereira, Brooke A., Tyma, Victoria M., Lee, Victoria, Trpceski, Michael, Henry, Jake, Melenec, Pauline, Abdulkhalek, Lea, Nobis, Max, Metcalf, Xanthe L., Ritchie, Shona, Cadell, Antonia, Stoehr, Janett, Magenau, Astrid, Chacon-Fajardo, Diego, Chitty, Jessica L., O’Connell, Savannah, Zaratzian, Anaiis, Tayao, Michael, Da Silva, Andrew, Lyons, Ruth J., Goldstein, Leonard D., Dale, Ashleigh, Rookyard, Alexander, Connolly, Angela, Crossett, Ben, Tran, Yen T. H., Kaltzis, Peter, Vennin, Claire, Dinevska, Marija, Croucher, David R., Samra, Jaswinder, Mittal, Anubhav, Weatheritt, Robert J., Philp, Andrew, Del Monte-Nieto, Gonzalo, Zhang, Lei, Enriquez, Ronaldo F., Cox, Thomas R., Shi, Yan-Chuan C., Pinese, Mark, Waddell, Nicola, Sim, Hao-Wen, Chtanova, Tatyana, Wang, Yingxiao, Joshua, Anthony M., Chantrill, Lorraine, Evans, Thomas R. Jeffry, Gill, Anthony J., Morton, Jennifer P., Pajic, Marina, Christ, Daniel, Herzog, Herbert, Timpson, Paul, Herrmann, David
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 14.03.2025
Subjects:	Animals Arginine - analogs & derivatives Biomedicine and Life Sciences Cancer Cell Biology Cell Line, Tumor Cell Movement - drug effects Disease Models, Animal Gene Expression Regulation, Neoplastic Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - secondary Mice Mice, Knockout Mutation Neoplasm Metastasis Neuropeptide Y - genetics Neuropeptide Y - metabolism Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Receptors, Neuropeptide Y - antagonists & inhibitors Receptors, Neuropeptide Y - genetics Receptors, Neuropeptide Y - metabolism SciAdv r-articles Signal Transduction - drug effects Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
ISSN:	2375-2548, 2375-2548
Online Access:	Get full text
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