Raman imaging of single living cells: probing effects of non-cytotoxic doses of an anti-cancer drug

Identifying cell response to a chemotherapy drug treatment, in particular at the single cell level, is an important issue in patient management. This study aims at evaluating the effect of gemcitabine on single living cells using micro-Raman imaging. We used as a model the non-small lung cancer cell...

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Bibliographic Details
Published in:	Analyst (London) Vol. 136; no. 13; p. 2718
Main Authors:	Draux, Florence, Gobinet, Cyril, Sulé-Suso, Josep, Manfait, Michel, Jeannesson, Pierre, Sockalingum, Ganesh D
Format:	Journal Article
Language:	English
Published:	England 07.07.2011
Subjects:	Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Cell Line, Tumor Cell Proliferation - drug effects Cell Survival Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Deoxycytidine - toxicity DNA - metabolism Dose-Response Relationship, Drug Drug Screening Assays, Antitumor - methods Humans Intracellular Space - drug effects Intracellular Space - metabolism Molecular Imaging - methods Principal Component Analysis Proteins - metabolism Quartz RNA - metabolism Single-Cell Analysis - methods Spectrum Analysis, Raman
ISSN:	1364-5528, 1364-5528
Online Access:	Get more information
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