A novel gene, optrA, that confers transferable resistance to oxazolidinones and phenicols and its presence in Enterococcus faecalis and Enterococcus faecium of human and animal origin

The oxazolidinone-resistant Enterococcus faecalis E349 from a human patient tested negative for the cfr gene and 23S rRNA mutations. Here we report the identification of a novel oxazolidinone resistance gene, optrA, and a first investigation of the extent to which this gene was present in E. faecali...

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Bibliographic Details
Published in:	Journal of antimicrobial chemotherapy Vol. 70; no. 8; p. 2182
Main Authors:	Wang, Yang, Lv, Yuan, Cai, Jiachang, Schwarz, Stefan, Cui, Lanqing, Hu, Zhidong, Zhang, Rong, Li, Jun, Zhao, Qin, He, Tao, Wang, Dacheng, Wang, Zheng, Shen, Yingbo, Li, Yun, Feßler, Andrea T, Wu, Congming, Yu, Hao, Deng, Xuming, Xia, Xi, Shen, Jianzhong
Format:	Journal Article
Language:	English
Published:	England 01.08.2015
Subjects:	Animals Anti-Bacterial Agents - pharmacology Chloramphenicol - analogs & derivatives Chloramphenicol - pharmacology Cluster Analysis Conjugation, Genetic DNA, Bacterial - chemistry DNA, Bacterial - genetics Drug Resistance, Bacterial Enterococcus faecalis - drug effects Enterococcus faecalis - genetics Enterococcus faecalis - isolation & purification Enterococcus faecium - drug effects Enterococcus faecium - genetics Enterococcus faecium - isolation & purification Gene Transfer, Horizontal Genes, Bacterial Gram-Positive Bacterial Infections - microbiology Gram-Positive Bacterial Infections - veterinary Humans Microbial Sensitivity Tests Molecular Sequence Data Oxazolidinones - pharmacology Phylogeny Plasmids Sequence Analysis, DNA Sequence Homology Transformation, Bacterial interspecies transfer linezolid plasmids florfenicol tedizolid enterococci
ISSN:	1460-2091, 1460-2091
Online Access:	Get more information
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