Women with TT genotype for eNOS gene are more responsive in lowering blood pressure in response to exercise

The aim of this study was to investigate whether -786T>C endothelial nitric oxide synthase (eNOS) gene polymorphism might influence the effect of long-term exercise training (ET) on the blood pressure and its relationship with NO production in healthy postmenopausal women. Longitudinal study. Fif...

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Bibliographic Details
Published in:European journal of cardiovascular prevention and rehabilitation Vol. 17; no. 6; p. 676
Main Authors: Sponton, Carlos H G, Rezende, Tiago M, Mallagrino, Pamella A, Franco-Penteado, Carla F, Bezerra, Marcos André C, Zanesco, Angelina
Format: Journal Article
Language:English
Published: England 01.12.2010
Subjects:
5' Flanking Region
Blood Pressure
Double-Blind Method
Exercise Therapy
Female
Genotype
Humans
Hypertension - enzymology
Hypertension - genetics
Hypertension - physiopathology
Hypertension - therapy
Longitudinal Studies
Middle Aged
Nitrates - blood
Nitric Oxide Synthase Type III - genetics
Nitrites - blood
Phenotype
Polymorphism, Genetic
Postmenopause
Time Factors
Treatment Outcome
Women's Health
ISSN:1741-8275, 1741-8275
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Summary:The aim of this study was to investigate whether -786T>C endothelial nitric oxide synthase (eNOS) gene polymorphism might influence the effect of long-term exercise training (ET) on the blood pressure and its relationship with NO production in healthy postmenopausal women. Longitudinal study. Fifty-five postmenopausal women were studied in a double-blinded design. ET was performed for 3 days a week, each session consisting of 60 min during 6 months, in an intensity of 50-70% VO2max. After that, eNOS genotype analysis was performed and women were divided into two groups: TC+CC (n=41) and TT (n=14) genotype. No changes were found in the anthropometric parameters after ET in both the groups. Systolic and diastolic BP values were significantly reduced in both the groups, but women with TT genotype were more responsive in lowering BP as compared with those with TC+CC genotype. Plasma nitrite/nitrate concentrations were similar at baseline in both the groups, but the magnitude of increment in NO production in response to ET was higher in women with TT genotype as compared with those with TC+CC genotype. Our study shows clearly that women with or without eNOS gene polymorphism had no differences in NO production at basal conditions, but when physical exercise is applied an evident difference is detected showing that the presence of -786T>C eNOS gene polymorphism had a significant impact in the health-promoting effect of aerobic physical training on the blood pressure in postmenopausal women.
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ISSN:1741-8275
1741-8275
DOI:10.1097/HJR.0b013e32833a1301