Experimental and engineering approaches to intracellular communication

Communication between and within cells is essential for multicellular life. While intracellular signal transduction pathways are often specified in molecular terms, the information content they transmit remains poorly defined. Here, we review research efforts to merge biological experimentation with...

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Veröffentlicht in:Essays in biochemistry Jg. 62; H. 4; S. 515
Hauptverfasser: Albeck, John G, Pargett, Michael, Davies, Alexander E
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 26.10.2018
Schlagworte:
Cell Communication
Humans
Models, Biological
Signal Transduction
Systems Biology
systems biology
extracellular signal-regulated kinases
imaging techniques
receptor tyrosine kinases
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ISSN:1744-1358, 1744-1358
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Zusammenfassung:Communication between and within cells is essential for multicellular life. While intracellular signal transduction pathways are often specified in molecular terms, the information content they transmit remains poorly defined. Here, we review research efforts to merge biological experimentation with concepts of communication that emerge from the engineering disciplines of signal processing and control theory. We discuss the challenges of performing experiments that quantitate information transfer at the molecular level, and we highlight recent studies that have advanced toward a clearer definition of the information content carried by signaling molecules. Across these studies, we emphasize a theme of increasingly well-matched experimental and theoretical approaches to decode the data streams directing cellular behavior.
Bibliographie:ObjectType-Article-1
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ISSN:1744-1358
1744-1358
DOI:10.1042/EBC20180024