Imaging spectrum of immunomodulating, chemotherapeutic and radiation therapy related intracranial effects

A wide range of treatment-related side effects result in specific neurologic symptoms and signs and neuroimaging features. Even to the most seasoned neuroradiologist, elucidating therapy-related side effects from other common mimics can be challenging. We provide a pictorial survey of some common an...

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Bibliographic Details
Published in:British journal of radiology Vol. 91; no. 1082; p. 20170553
Main Authors: Lincoln, Christie Mary, Fata, Peter, Sotardi, Susan, Pohlen, Michael, Uribe, Tomas, Bello, Jacqueline A.
Format: Journal Article
Language:English
Published: England The British Institute of Radiology 01.02.2018
Subjects:
Autoimmune Hypophysitis - diagnostic imaging
Autoimmune Hypophysitis - etiology
Brain - diagnostic imaging
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Demyelinating Diseases - diagnostic imaging
Demyelinating Diseases - etiology
Diagnostic Imaging - methods
Diagnostic Radiology
Disease Progression
Drug-Related Side Effects and Adverse Reactions
Glioblastoma - diagnostic imaging
Glioblastoma - pathology
Humans
Immune Reconstitution Inflammatory Syndrome - diagnostic imaging
Immune Reconstitution Inflammatory Syndrome - etiology
Multiple Sclerosis - drug therapy
Posterior Leukoencephalopathy Syndrome - diagnostic imaging
Posterior Leukoencephalopathy Syndrome - etiology
RADIODIAGNOSIS - Central nervous system
Radiotherapy - adverse effects
Review
ISSN:0007-1285, 1748-880X, 1748-880X
Online Access:Get full text
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Description
Summary:A wide range of treatment-related side effects result in specific neurologic symptoms and signs and neuroimaging features. Even to the most seasoned neuroradiologist, elucidating therapy-related side effects from other common mimics can be challenging. We provide a pictorial survey of some common and uncommon medication-induced and therapy-related neuroimaging manifestations, discuss pathophysiology and common pitfalls in imaging and diagnosis. A case-based review is utilized to depict scenarios on a routine basis in a general radiology or neuroradiology practice such as medication-induced posterior reversible encephalopathy syndrome to the more challenging cases of pseudoprogression and pseudoregression in temozolmide and bevacizumab therapy in gliobastoma treatment protocols. Knowledge of the treatment-induced imaging abnormalities is essential in the accurate interpretation and diagnosis from the most routine to most challenging of clinical situations. We provide a pictorial review for the radiologist to employ in order to be an invaluable provider to our clinical colleagues and patients.
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ISSN:0007-1285
1748-880X
1748-880X
DOI:10.1259/bjr.20170553