Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects

Immunization of humans with whole sporozoites confers complete, sterilizing immunity against malaria infection. However, achieving consistent safety while maintaining immunogenicity of whole parasite vaccines remains a formidable challenge. We generated a genetically attenuated Plasmodium falciparum...

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Bibliographic Details
Published in:	Science translational medicine Vol. 9; no. 371
Main Authors:	Kublin, James G, Mikolajczak, Sebastian A, Sack, Brandon K, Fishbaugher, Matt E, Seilie, Annette, Shelton, Lisa, VonGoedert, Tracie, Firat, Melike, Magee, Sara, Fritzen, Emma, Betz, Will, Kain, Heather S, Dankwa, Dorender A, Steel, Ryan W J, Vaughan, Ashley M, Noah Sather, D, Murphy, Sean C, Kappe, Stefan H I
Format:	Journal Article
Language:	English
Published:	United States 04.01.2017
Subjects:	Adult Animals Antibodies, Protozoan - blood Female Gene Deletion Genetic Engineering Humans Immunoglobulin G - blood Malaria Vaccines - genetics Malaria Vaccines - immunology Malaria, Falciparum - prevention & control Male Mice Mice, Inbred BALB C Middle Aged Plasmodium falciparum - genetics Plasmodium falciparum - immunology Protozoan Proteins - genetics Sporozoites - genetics Sporozoites - immunology Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Young Adult
ISSN:	1946-6242
Online Access:	Get more information
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