Antarease-like Zn-metalloproteases are ubiquitous in the venom of different scorpion genera

The venoms of several scorpion species have long been associated with pancreatitis in animal models and humans. Antarease, a Zn-metalloprotease from Tityus serrulatus, is able to penetrate intact pancreatic tissue and disrupts the normal vesicular traffic necessary for secretion, so it could play a...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1840; no. 6; pp. 1738 - 1746
Main Authors:	Ortiz, Ernesto, Rendón-Anaya, Martha, Rego, Solange Cristina, Schwartz, Elisabeth Ferroni, Possani, Lourival Domingos
Format:	Journal Article
Language:	English
Published:	Netherlands 01.06.2014
Subjects:	Amino Acid Sequence animal models antivenoms Base Sequence cDNA libraries complementary DNA humans Metalloproteases - chemistry Metalloproteases - genetics Metalloproteases - physiology metalloproteinases Models, Molecular molecular cloning Molecular Dynamics Simulation Molecular Sequence Data pancreatitis phylogeny Phylogeography physiological transport polymerase chain reaction Scorpion Venoms - enzymology secretion sequence analysis Tityus serrulatus venoms Zn-metalloprotease Scorpion Antarease Pancreatitis cDNA library
ISSN:	0304-4165, 0006-3002
Online Access:	Get full text
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