m6A-modified circNFIX promotes ovarian cancer progression and immune escape via activating IL-6R/JAK1/STAT3 signaling by sponging miR-647

[Display omitted] •circNFIX was overexpressed in OC and correlated to poor prognosis.•circNFIX inhibition reduced tumor growth, metastasis and immune escape in OC.•circNFIX was activate by IGF2BPs in a m6A modification manner.•circNFIX promoted IL-6R expression via sponging miR-647.•miR-647 was nega...

Full description

Saved in:

Bibliographic Details
Published in:	International immunopharmacology Vol. 124; no. Pt A; p. 110879
Main Authors:	Wang, Ruiyu, Ye, Hui, Yang, Bowen, Ao, Mengyin, Yu, Xiuzhang, Wu, Yuke, Xi, Mingrong, Hou, Minmin
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01.11.2023
Subjects:	circNFIX IGF2BP2 Immune escape m6A modification miR-647 Ovarian cancer ceRNA m6A modification IGF2BP NFIX circRNA DAB H&E qRT-PCR IP IgG Immune escape miR-647 IL-6 Ovarian cancer OC FBS RIP PD-L1 miRNA CCK-8 IGF2BP2 circNFIX PD-1 ELISA
ISSN:	1567-5769, 1878-1705, 1878-1705
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!