Hierarchical reconstructions of cardiac tissue

We consider the general problem of comparing and integrating computational models of cardiac tissue at different levels of physiological detail. We use a general theory of synchronous concurrent algorithms to model spatially extended biological systems, and expand the theory to create hierarchical m...

Full description

Saved in:
Bibliographic Details
Published in:Chaos, solitons and fractals Vol. 13; no. 8; pp. 1581 - 1612
Main Authors: Poole, M.J., Holden, A.V., Tucker, J.V.
Format: Journal Article Conference Proceeding
Language:English
Published: Elsevier Ltd 01.06.2002
Subjects:
Automata theory
Cardiology
Mathematical models
Ordinary differential equations
Partial differential equations
ISSN:0960-0779, 1873-2887
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We consider the general problem of comparing and integrating computational models of cardiac tissue at different levels of physiological detail. We use a general theory of synchronous concurrent algorithms to model spatially extended biological systems, and expand the theory to create hierarchical models by relating observable behaviour at different levels. The general concepts and methods are illustrated by a detailed case study of electrical behaviour in cardiac tissue, in which models based on coupled systems of ordinary differential equations, partial differential equations (PDEs) and cellular automata (CAs) are compared and combined.
Bibliography:SourceType-Books-1
ObjectType-Book-1
content type line 25
ObjectType-Conference-2
SourceType-Conference Papers & Proceedings-2
ISSN:0960-0779
1873-2887
DOI:10.1016/S0960-0779(01)00169-2