Hierarchical reconstructions of cardiac tissue

We consider the general problem of comparing and integrating computational models of cardiac tissue at different levels of physiological detail. We use a general theory of synchronous concurrent algorithms to model spatially extended biological systems, and expand the theory to create hierarchical m...

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Vydáno v:Chaos, solitons and fractals Ročník 13; číslo 8; s. 1581 - 1612
Hlavní autoři: Poole, M.J., Holden, A.V., Tucker, J.V.
Médium: Journal Article Konferenční příspěvek
Jazyk:angličtina
Vydáno: Elsevier Ltd 01.06.2002
Témata:
Automata theory
Cardiology
Mathematical models
Ordinary differential equations
Partial differential equations
ISSN:0960-0779, 1873-2887
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Shrnutí:We consider the general problem of comparing and integrating computational models of cardiac tissue at different levels of physiological detail. We use a general theory of synchronous concurrent algorithms to model spatially extended biological systems, and expand the theory to create hierarchical models by relating observable behaviour at different levels. The general concepts and methods are illustrated by a detailed case study of electrical behaviour in cardiac tissue, in which models based on coupled systems of ordinary differential equations, partial differential equations (PDEs) and cellular automata (CAs) are compared and combined.
Bibliografie:SourceType-Books-1
ObjectType-Book-1
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ObjectType-Conference-2
SourceType-Conference Papers & Proceedings-2
ISSN:0960-0779
1873-2887
DOI:10.1016/S0960-0779(01)00169-2