Malignant Hidroacanthoma Simplex: A Case Report

Introduction: Malignant hidroacanthoma simplex (MHS) is an exceedingly rare cutaneous neoplasm with limited documented cases. This report highlights a distinctive case of MHS with prolonged clinical evolution, emphasizing its diagnostic challenges and management outcomes. Case Presentation: A 64-yea...

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Bibliographic Details
Published in:Case reports in dermatology Vol. 17; no. 1; pp. 246 - 251
Main Authors: Ren, Xiangxiang, Xie, Tianhao, Liu, Lingyun, Yang, Fan, Zhang, Meng
Format: Journal Article
Language:English
Published: Switzerland S. Karger AG 11.06.2025
Subjects:
Single Case
Surgical resection
Malignant hidroacanthoma simplex
ISSN:1662-6567, 1662-6567
Online Access:Get full text
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Summary:Introduction: Malignant hidroacanthoma simplex (MHS) is an exceedingly rare cutaneous neoplasm with limited documented cases. This report highlights a distinctive case of MHS with prolonged clinical evolution, emphasizing its diagnostic challenges and management outcomes. Case Presentation: A 64-year-old female presented with a right lumbar mass persisting for over 2 decades, exhibiting progressive enlargement in the past 5 years. Clinical examination revealed a solitary reddish-brown proliferative plaque (3.5 cm × 4.0 cm) on the right waist, characterized by irregular borders, a rough surface, and reddish-brown crusts. Histopathological findings included hyperkeratosis, irregular epidermal hyperplasia, hypertrophic stratum spinosum, and tumor cells displaying pale eosinophilic cytoplasm, vacuolated nuclei, small nucleoli, and atypical mitotic figures. Notably, tumor cells were confined to the epidermis without dermal invasion. The patient underwent local extended excision, and postoperative surveillance over 15 months demonstrated no evidence of recurrence or lymph node metastasis. Conclusion: This case underscores the indolent yet locally persistent nature of MHS. Complete surgical excision remains the cornerstone of management, with favorable outcomes achievable in the absence of dermal infiltration. Long-term follow-up is critical to monitor potential recurrence.
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ISSN:1662-6567
1662-6567
DOI:10.1159/000546700