Tubular Apocrine Adenoma with Uncertain Malignant Findings: Report of a Case and Review of the Literature
Introduction: Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is considered as benign tumor; however, it may be difficult to differentiate TAA from metastatic or primary carcinoma. Case Presentation: A...
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| Published in: | Case reports in dermatology Vol. 17; no. 1; pp. 240 - 245 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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Switzerland
S. Karger AG
10.04.2025
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| ISSN: | 1662-6567, 1662-6567 |
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| Abstract | Introduction: Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is considered as benign tumor; however, it may be difficult to differentiate TAA from metastatic or primary carcinoma. Case Presentation: A woman in her 90s presented with a pale red nodule on her right posterior auricle for 3 years. Histology showed several tubular structures contained two layers in the dermis. These showed decapitation secretion. At the periphery of the lesion, squamoid tumor cells formed nest-like patterns. Some squamoid tumor cells exhibited multinucleation. Based on the histopathological, immunohistochemical, and molecular biology findings, the tumor was diagnosed as TAA with undefined malignant changes. Conclusion: TAA is a rare sweat gland neoplasm. Although TAA is generally benign, it can exhibit aggressive features, making thorough pathological evaluation crucial to rule out malignancy. |
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| AbstractList | Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is considered as benign tumor; however, it may be difficult to differentiate TAA from metastatic or primary carcinoma.IntroductionTubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is considered as benign tumor; however, it may be difficult to differentiate TAA from metastatic or primary carcinoma.A woman in her 90s presented with a pale red nodule on her right posterior auricle for 3 years. Histology showed several tubular structures contained two layers in the dermis. These showed decapitation secretion. At the periphery of the lesion, squamoid tumor cells formed nest-like patterns. Some squamoid tumor cells exhibited multinucleation. Based on the histopathological, immunohistochemical, and molecular biology findings, the tumor was diagnosed as TAA with undefined malignant changes.Case PresentationA woman in her 90s presented with a pale red nodule on her right posterior auricle for 3 years. Histology showed several tubular structures contained two layers in the dermis. These showed decapitation secretion. At the periphery of the lesion, squamoid tumor cells formed nest-like patterns. Some squamoid tumor cells exhibited multinucleation. Based on the histopathological, immunohistochemical, and molecular biology findings, the tumor was diagnosed as TAA with undefined malignant changes.TAA is a rare sweat gland neoplasm. Although TAA is generally benign, it can exhibit aggressive features, making thorough pathological evaluation crucial to rule out malignancy.ConclusionTAA is a rare sweat gland neoplasm. Although TAA is generally benign, it can exhibit aggressive features, making thorough pathological evaluation crucial to rule out malignancy. Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is considered as benign tumor; however, it may be difficult to differentiate TAA from metastatic or primary carcinoma. A woman in her 90s presented with a pale red nodule on her right posterior auricle for 3 years. Histology showed several tubular structures contained two layers in the dermis. These showed decapitation secretion. At the periphery of the lesion, squamoid tumor cells formed nest-like patterns. Some squamoid tumor cells exhibited multinucleation. Based on the histopathological, immunohistochemical, and molecular biology findings, the tumor was diagnosed as TAA with undefined malignant changes. TAA is a rare sweat gland neoplasm. Although TAA is generally benign, it can exhibit aggressive features, making thorough pathological evaluation crucial to rule out malignancy. Introduction: Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is considered as benign tumor; however, it may be difficult to differentiate TAA from metastatic or primary carcinoma. Case Presentation: A woman in her 90s presented with a pale red nodule on her right posterior auricle for 3 years. Histology showed several tubular structures contained two layers in the dermis. These showed decapitation secretion. At the periphery of the lesion, squamoid tumor cells formed nest-like patterns. Some squamoid tumor cells exhibited multinucleation. Based on the histopathological, immunohistochemical, and molecular biology findings, the tumor was diagnosed as TAA with undefined malignant changes. Conclusion: TAA is a rare sweat gland neoplasm. Although TAA is generally benign, it can exhibit aggressive features, making thorough pathological evaluation crucial to rule out malignancy. |
| Author | Miyamoto, Kodai Tomaru, Utano Yanagi, Teruki Ujiie, Hideyuki Tokuchi, Keiko Anan, Takashi Nakazato, Shinichi Maeda, Takuya |
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| Cites_doi | 10.1016/s0190-9622(84)70221-0 10.1111/1346-8138.14494 10.1111/cup.14509 10.1016/j.humpath.2014.01.006 10.1097/00000372-199310000-00014 10.1038/ng.2316 |
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| Keywords | Appendage tumors Sweat gland tumor Malignant findings Tubular apocrine adenoma Apocrine carcinoma |
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| Snippet | Introduction: Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally,... Tubular apocrine adenoma (TAA) is a rare sweat gland tumor, usually presenting as a well-defined, red to brown nodule on the scalp. Generally, TAA is... |
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| Title | Tubular Apocrine Adenoma with Uncertain Malignant Findings: Report of a Case and Review of the Literature |
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