Splenomegaly in FOLFOX-naive stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy

Background Chemotherapy-associated hepatotoxicity is a common cause of postoperative complications after major hepatectomy. Splenomegaly may indicate portal hypertension due to chemotherapy. To identify chemotherapy-naïve patients with liver damage, the splenic volume (SV) and aspartate aminotransfe...

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Bibliographic Details
Published in:	International journal of clinical oncology Vol. 16; no. 3; pp. 257 - 263
Main Authors:	Miura, Kazuhiro, Nakano, Hiroshi, Sakurai, Joe, Kobayashi, Shinjiro, Koizumi, Satoshi, Arai, Tatsuhiro, Shimamura, Tsukasa, Makizumi, Ryoji, Yamada, Kyoji, Miyajima, Nobuyoshi, Otsubo, Takehito, Koike, Junki
Format:	Journal Article
Language:	English
Published:	Japan Springer Japan 01.06.2011 Springer Nature B.V
Subjects:	Adenocarcinoma - drug therapy Adenocarcinoma - pathology Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aspartate aminotransferase to platelet ratio index Aspartate Aminotransferases - metabolism Bevacizumab Camptothecin - administration & dosage Camptothecin - adverse effects Camptothecin - analogs & derivatives Cancer Research Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - etiology Chemotherapy Chemotherapy-associated hepatotoxicity Chemotherapy-naive patients Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Humans Leucovorin - administration & dosage Leucovorin - adverse effects Liver cancer Male Medicine Medicine & Public Health Middle Aged Neoplasm Staging Oncology Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects Original Article Platelet Count Radiography Retrospective Studies Splenic volume index Splenomegaly Splenomegaly - blood Splenomegaly - chemically induced Splenomegaly - diagnostic imaging Splenomegaly - enzymology Surgical Oncology Toxicity Aspartate aminotransferase to platelet ratio index Splenomegaly Chemotherapy-naïve patients Splenic volume index Chemotherapy-associated hepatotoxicity
ISSN:	1341-9625, 1437-7772, 1437-7772
Online Access:	Get full text
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