The status and trends of type 2 diabetic osteoporosis research: a global bibliometric and visualization analysis over the past 20 years

Type 2 diabetic osteoporosis (T2DOP) has received considerable attention due to its accelerated bone deterioration and significantly increased fracture risk. Unlike classical osteoporosis, patients with T2DOP often exhibit a paradoxical pattern: they have normal or even elevated bone mineral density...

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Published in:Frontiers in clinical diabetes and healthcare (online) Vol. 6; p. 1596938
Main Authors: Hou, Haiyan, Zhu, Liying
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 2025
Subjects:
bibliometrics
Clinical Diabetes and Healthcare
global health trends
hotspots
osteoporosis
type 2 diabetes mellitus
VOSviewer
bibliometrics
type 2 diabetes mellitus
diabetes complications
global health trends
osteoporosis
hotspots
VOSviewer
ISSN:2673-6616, 2673-6616
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Summary:Type 2 diabetic osteoporosis (T2DOP) has received considerable attention due to its accelerated bone deterioration and significantly increased fracture risk. Unlike classical osteoporosis, patients with T2DOP often exhibit a paradoxical pattern: they have normal or even elevated bone mineral density (BMD) in early stages despite deterioration in bone microarchitecture. This paradox highlights the clinical importance of identifying T2DOP as a distinct and critical subtype of secondary osteoporosis. We conducted a bibliometric analysis of literature on T2DOP published over the past 20 Years(from 2001 to 2020), using data retrieved from the Web of Science Core Collection database. Bibliometric networks were visualized and analyzed using VOSviewer. Publication trends, geographic contributions, research hotspots, and keyword clusters were systematically examined. Over the past 20 Years, global research output on T2DOP steadily increased, with major contributions from North America, East Asia, and Western Europe. Identified research hotspots included risk prediction, biomarkers (e.g., advanced glycation end-products), complication management, population-specific characteristics (e.g., postmenopausal women), and therapeutic strategies (e.g., metformin). Notably, lifestyle intervention has recently emerged as an important new research direction. This study provides the first comprehensive bibliometric analysis and visualization of global research trends and hotspots in T2DOP, highlighting critical insights for clinical practice, including the identification of at-risk populations, biomarker-guided risk assessment, and therapeutic optimization, which complements existing clinical meta-analyses. Future research efforts should emphasize multidisciplinary collaboration and validation of the long-term efficacy of lifestyle interventions. For clinical practice, integrating bone density evaluation with biomarker screening (e.g., osteocalcin) in diabetic patients could enhance early fracture prevention. Public health initiatives should prioritize lifestyle interventions in high-risk populations (e.g., postmenopausal women) to mitigate the growing burden of diabetic osteoporosis.
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Reviewed by: Zitong Zhang, Icahn School of Medicine at Mount Sinai, United States
Fawaz A. Alassaf, University of Mosul, Iraq
Ziyue Wang, University of Massachusetts Medical School, United States
Edited by: Antonio Magan-Fernandez, University of Granada, Spain
ISSN:2673-6616
2673-6616
DOI:10.3389/fcdhc.2025.1596938