Neuroinflammation: An astrocyte perspective
Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles in health and disease. Recent technologies have uncovered the functional heterogeneity of astrocytes and their extensive interactions with other cell types in the CNS. In this Review, we highlight the intr...
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| Veröffentlicht in: | Science translational medicine Jg. 15; H. 721; S. eadi7828 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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08.11.2023
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| ISSN: | 1946-6242, 1946-6242 |
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| Abstract | Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles in health and disease. Recent technologies have uncovered the functional heterogeneity of astrocytes and their extensive interactions with other cell types in the CNS. In this Review, we highlight the intricate interactions between astrocytes, other CNS-resident cells, and CNS-infiltrating cells as well as their potential therapeutic value in the context of inflammation and neurodegeneration. |
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| AbstractList | Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles in health and disease. Recent technologies have uncovered the functional heterogeneity of astrocytes and their extensive interactions with other cell types in the CNS. In this Review, we highlight the intricate interactions between astrocytes, other CNS-resident cells, and CNS-infiltrating cells as well as their potential therapeutic value in the context of inflammation and neurodegeneration. Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles in health and disease. Recent technologies have uncovered the functional heterogeneity of astrocytes and their extensive interactions with other cell types in the CNS. In this Review, we highlight the intricate interactions between astrocytes, other CNS-resident cells, and CNS-infiltrating cells as well as their potential therapeutic value in the context of inflammation and neurodegeneration.Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles in health and disease. Recent technologies have uncovered the functional heterogeneity of astrocytes and their extensive interactions with other cell types in the CNS. In this Review, we highlight the intricate interactions between astrocytes, other CNS-resident cells, and CNS-infiltrating cells as well as their potential therapeutic value in the context of inflammation and neurodegeneration. |
| Author | Flausino, Lucas E Lee, Hong-Gyun Lee, Joon-Hyuk Quintana, Francisco J |
| Author_xml | – sequence: 1 givenname: Hong-Gyun orcidid: 0000-0001-5960-5504 surname: Lee fullname: Lee, Hong-Gyun organization: Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA – sequence: 2 givenname: Joon-Hyuk orcidid: 0000-0002-6249-4291 surname: Lee fullname: Lee, Joon-Hyuk organization: Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA – sequence: 3 givenname: Lucas E orcidid: 0000-0002-2800-0374 surname: Flausino fullname: Flausino, Lucas E organization: Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA – sequence: 4 givenname: Francisco J orcidid: 0000-0001-8156-0736 surname: Quintana fullname: Quintana, Francisco J organization: Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37939162$$D View this record in MEDLINE/PubMed |
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