AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement

Although angiotensin IV (Ang IV) was thought initially to be an inactive product of Ang II degradation, it was subsequently shown that the hexapeptide markedly enhances learning and memory in normal rodents and reverses the memory deficits seen in animal models of amnesia. These central nervous syst...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism Vol. 14; no. 2; pp. 72 - 77
Main Authors: Albiston, Anthony L, Mustafa, Tomris, McDowall, Sharon G, Mendelsohn, Frederick A.O, Lee, Joohyung, Chai, Siew Yeen
Format: Journal Article
Language:English
Published: London Elsevier 01.03.2003
Subjects:
Aminopeptidases - metabolism
Anatomical correlates of behavior
Angiotensin II - administration & dosage
Angiotensin II - analogs & derivatives
Angiotensin II - metabolism
Angiotensin II - physiology
Animals
Behavioral psychophysiology
Biological and medical sciences
Brain - metabolism
Cystinyl Aminopeptidase
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
Humans
Injections, Intraventricular
Insulin - physiology
Memory - drug effects
Memory - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Receptors, Angiotensin - metabolism
Signal Transduction
Tissue Distribution
Learning
Peptidases
Acquisition process
Enzyme
Aminopeptidases
Memory
Hydrolases
Review
Angiotensin receptor
ISSN:1043-2760
Online Access:Get full text
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Summary:Although angiotensin IV (Ang IV) was thought initially to be an inactive product of Ang II degradation, it was subsequently shown that the hexapeptide markedly enhances learning and memory in normal rodents and reverses the memory deficits seen in animal models of amnesia. These central nervous system effects of Ang IV are mediated by binding to a specific site, known as the AT(4) receptor, which is found in appreciable levels throughout the brain and is concentrated particularly in regions involved in cognition. This field of research was redefined by the identification of the AT(4) receptor as the transmembrane enzyme, insulin-regulated membrane aminopeptidase (IRAP). Here, we explore the potential mechanisms by which Ang IV binding to IRAP leads to the facilitation of learning and memory.
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ISSN:1043-2760
DOI:10.1016/S1043-2760(02)00037-1