Influenza Vaccination of Pregnant Women and Protection of Their Infants

In two trials of a trivalent inactivated influenza vaccine in pregnant women in South Africa, HIV-infected and HIV-uninfected vaccine recipients had increased influenza antibody titers and decreased influenza attack rates. Pregnant women are designated as a priority group for seasonal influenza vacc...

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Vydáno v:	The New England journal of medicine Ročník 371; číslo 10; s. 918 - 931
Hlavní autoři:	Madhi, Shabir A, Cutland, Clare L, Kuwanda, Locadiah, Weinberg, Adriana, Hugo, Andrea, Jones, Stephanie, Adrian, Peter V, van Niekerk, Nadia, Treurnicht, Florette, Ortiz, Justin R, Venter, Marietjie, Violari, Avy, Neuzil, Kathleen M, Simões, Eric A.F, Klugman, Keith P, Nunes, Marta C
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Waltham, MA Massachusetts Medical Society 04.09.2014
Témata:	Adult Babies Biological and medical sciences Double-Blind Method Female General aspects Hemagglutination inhibition HIV HIV Infections - complications HIV Infections - immunology Human immunodeficiency virus Human viral diseases Humans Immune response Immunization Immunogenicity Infant Infant, Newborn Infant, Premature Infants Infectious diseases Influenza Influenza Vaccines - immunology Influenza, Human - prevention & control Kaplan-Meier Estimate Male Medical sciences Neonates Polymerase chain reaction Pregnancy Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - prevention & control Pregnancy Outcome Seroconversion South Africa Vaccination Vaccine efficacy Vaccines Vaccines, Inactivated - immunology Viral diseases Viral diseases of the respiratory system and ent viral diseases Womens health Young Adult South Africa United States > US Human Vaccination Infant Infection Prevention Pregnancy Medicine Immunoprophylaxis Viral disease Influenza Female Woman Protection
ISSN:	0028-4793, 1533-4406, 1533-4406
On-line přístup:	Získat plný text
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Shrnutí:	In two trials of a trivalent inactivated influenza vaccine in pregnant women in South Africa, HIV-infected and HIV-uninfected vaccine recipients had increased influenza antibody titers and decreased influenza attack rates. Pregnant women are designated as a priority group for seasonal influenza vaccination by the World Health Organization (WHO) 1 because of their heightened susceptibility to severe influenza from the second trimester to the early postpartum period. 2 , 3 Since pregnancy is associated with immunomodulation, including the attenuation of cell-mediated immune responses, 4 the efficacy of inactivated influenza vaccine (IIV) in pregnant women may differ from its efficacy in healthy nonpregnant women and in men. 5 This difference in vaccine efficacy could be further accentuated in pregnant women infected with the human immunodeficiency virus (HIV), who are at heightened risk for severe influenza illness 6 – . . .
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1401480