Influenza Vaccination of Pregnant Women and Protection of Their Infants

In two trials of a trivalent inactivated influenza vaccine in pregnant women in South Africa, HIV-infected and HIV-uninfected vaccine recipients had increased influenza antibody titers and decreased influenza attack rates. Pregnant women are designated as a priority group for seasonal influenza vacc...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 371; no. 10; pp. 918 - 931
Main Authors: Madhi, Shabir A, Cutland, Clare L, Kuwanda, Locadiah, Weinberg, Adriana, Hugo, Andrea, Jones, Stephanie, Adrian, Peter V, van Niekerk, Nadia, Treurnicht, Florette, Ortiz, Justin R, Venter, Marietjie, Violari, Avy, Neuzil, Kathleen M, Simões, Eric A.F, Klugman, Keith P, Nunes, Marta C
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 04.09.2014
Subjects:
Adult
Babies
Biological and medical sciences
Double-Blind Method
Female
General aspects
Hemagglutination inhibition
HIV
HIV Infections - complications
HIV Infections - immunology
Human immunodeficiency virus
Human viral diseases
Humans
Immune response
Immunization
Immunogenicity
Infant
Infant, Newborn
Infant, Premature
Infants
Infectious diseases
Influenza
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Kaplan-Meier Estimate
Male
Medical sciences
Neonates
Polymerase chain reaction
Pregnancy
Pregnancy Complications, Infectious - immunology
Pregnancy Complications, Infectious - prevention & control
Pregnancy Outcome
Seroconversion
South Africa
Vaccination
Vaccine efficacy
Vaccines
Vaccines, Inactivated - immunology
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Womens health
Young Adult
South Africa
United States > US
Human
Vaccination
Infant
Infection
Prevention
Pregnancy
Medicine
Immunoprophylaxis
Viral disease
Influenza
Female
Woman
Protection
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:In two trials of a trivalent inactivated influenza vaccine in pregnant women in South Africa, HIV-infected and HIV-uninfected vaccine recipients had increased influenza antibody titers and decreased influenza attack rates. Pregnant women are designated as a priority group for seasonal influenza vaccination by the World Health Organization (WHO) 1 because of their heightened susceptibility to severe influenza from the second trimester to the early postpartum period. 2 , 3 Since pregnancy is associated with immunomodulation, including the attenuation of cell-mediated immune responses, 4 the efficacy of inactivated influenza vaccine (IIV) in pregnant women may differ from its efficacy in healthy nonpregnant women and in men. 5 This difference in vaccine efficacy could be further accentuated in pregnant women infected with the human immunodeficiency virus (HIV), who are at heightened risk for severe influenza illness 6 – . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1401480