Fluid-structure interaction analysis of a patient-specific right coronary artery with physiological velocity and pressure waveforms

Coupled fluid–structure interaction (FSI) analysis of the human right coronary artery (RCA) has been carried out to investigate the effects of wall compliance on coronary hemodynamics. A 3‐D model of a stenosed RCA was reconstructed based on multislice computerized tomography images. A velocity wave...

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Vydáno v:Communications in numerical methods in engineering Ročník 25; číslo 5; s. 565 - 580
Hlavní autoři: Torii, Ryo, Wood, Nigel B., Hadjiloizou, Nearchos, Dowsey, Andrew W., Wright, Andrew R., Hughes, Alun D., Davies, Justin, Francis, Darrel P., Mayet, Jamil, Yang, Guang-Zhong, Thom, Simon A. McG, Xu, X. Yun
Médium: Journal Article
Jazyk:angličtina
Vydáno: Chichester, UK John Wiley & Sons, Ltd 01.05.2009
Témata:
coronary atherosclerosis
fluid-structure interaction
physiological waveform
ISSN:1069-8299, 1099-0887
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Shrnutí:Coupled fluid–structure interaction (FSI) analysis of the human right coronary artery (RCA) has been carried out to investigate the effects of wall compliance on coronary hemodynamics. A 3‐D model of a stenosed RCA was reconstructed based on multislice computerized tomography images. A velocity waveform in the proximal RCA and a pressure waveform in the distal RCA of a patient with a severe stenosis were acquired with a catheter delivered wire probe and applied as boundary conditions. The arterial wall was modeled as a Mooney–Rivlin hyperelastic material. The predicted maximum wall displacement (3.85 mm) was comparable with the vessel diameter (∼4 mm), but the diameter variation was much smaller, 0.134 mm at the stenosis and 0.486 mm in the distal region. Comparison of the computational results between the FSI and rigid‐wall models showed that the instantaneous wall shear stress (WSS) distributions were affected by diameter variation in the arterial wall; increasing systolic blood pressure dilated the vessel and consequently lowered WSS, whereas the opposite occurred when pressure started to decrease. However, the effects of wall compliance on time‐averaged WSS (TAWSS) and oscillatory shear index (OSI) were insignificant (4.5 and 2.7% difference in maximum TAWSS and OSI, respectively). Copyright © 2009 John Wiley & Sons, Ltd.
Bibliografie:British Heart Foundation - No. PG/04/078; No. FS/05/034
Foundation for Circulatory Health - No. ICCH/07/5015
NIHR Biomedical Research Centre Funding Scheme
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ArticleID:CNM1231
istex:B0C1264F30D3243DF0E1033E7684434C0A38A866
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1069-8299
1099-0887
DOI:10.1002/cnm.1231