Chronic Thromboembolic Pulmonary Hypertension

Chronic thromboembolic pulmonary hypertension can develop after acute pulmonary embolus but is often overlooked until pulmonary hypertension has led to dyspnea and right ventricular dysfunction. This review provides a guide to early diagnosis and management. Chronic thromboembolic pulmonary hyperten...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 364; no. 4; pp. 351 - 360
Main Authors: Piazza, Gregory, Goldhaber, Samuel Z
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 27.01.2011
Subjects:
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Chronic Disease
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Endarterectomy
General aspects
Humans
Hypertension, Pulmonary - diagnosis
Hypertension, Pulmonary - etiology
Hypertension, Pulmonary - physiopathology
Hypertension, Pulmonary - therapy
Medical sciences
Pneumology
Pulmonary Artery - pathology
Pulmonary Embolism - complications
Pulmonary Embolism - diagnosis
Pulmonary Embolism - therapy
Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
Vascular disease
Medicine
Chronic
Respiratory disease
Cardiovascular disease
Thromboembolism
Thrombosis
Embolism
Pulmonary hypertension
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:Chronic thromboembolic pulmonary hypertension can develop after acute pulmonary embolus but is often overlooked until pulmonary hypertension has led to dyspnea and right ventricular dysfunction. This review provides a guide to early diagnosis and management. Chronic thromboembolic pulmonary hypertension is defined as mean pulmonary-artery pressure greater than 25 mm Hg that persists 6 months after pulmonary embolism is diagnosed. The 2008 World Symposium on Pulmonary Hypertension 1 emphasized the importance of chronic thromboembolic pulmonary hypertension, which occurs in 2 to 4% of patients after acute pulmonary embolism. 2 , 3 The frequency of this condition among patients with pulmonary hypertension is unknown. Patients with chronic thromboembolic pulmonary hypertension generally present in their 40s, although this condition has been reported in patients in other age groups. 2 The diagnosis is often overlooked because many patients do not have a history . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMra0910203