Underlying host risk factors for nontuberculous mycobacterial lung disease

Nontuberculous mycobacteria (NTM) are environmental microbes that cause a variety of human diseases, particularly chronic lung infections. Despite the fact that NTM are widespread in the environment, relatively few people develop NTM lung disease, suggesting intrinsic vulnerability in some individua...

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Vydáno v:Seminars in respiratory and critical care medicine Ročník 34; číslo 1; s. 110
Hlavní autoři: Chan, Edward D, Iseman, Michael D
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.02.2013
Témata:
Animals
Female
Humans
Lung Diseases - epidemiology
Lung Diseases - etiology
Lung Diseases - microbiology
Male
Mycobacterium Infections, Nontuberculous - epidemiology
Mycobacterium Infections, Nontuberculous - etiology
Mycobacterium Infections, Nontuberculous - microbiology
Nontuberculous Mycobacteria - isolation & purification
Postmenopause
Risk Factors
ISSN:1098-9048, 1098-9048
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Shrnutí:Nontuberculous mycobacteria (NTM) are environmental microbes that cause a variety of human diseases, particularly chronic lung infections. Despite the fact that NTM are widespread in the environment, relatively few people develop NTM lung disease, suggesting intrinsic vulnerability in some individuals. This paper reviews the evidence that underlying disorders predispose to NTM lung disease, in particular primary conditions that result in bronchiectasis, chronic obstructive pulmonary disease, α-1-antitrypsin anomalies, pneumoconiosis, pulmonary alveolar proteinosis, and frank immunosuppressive states such as that associated with the use of anti-tumor necrosis factor-α biologics, posttransplantation immunosuppression, and HIV infection. Over the past several decades, NTM lung disease has been increasingly identified in postmenopausal women with slender body habitus. Thus we will also review the clinical and experimental evidence which supports the observation that such individuals are predisposed to NTM lung disease.
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ISSN:1098-9048
1098-9048
DOI:10.1055/s-0033-1333573