Workshop cluster 1+γδ T‐cell receptor+ T cells from calves express high levels of interferon‐γ in response to stimulation with interleukin‐12 and ‐18
Summary γδ T‐cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper‐1 bias. We investigated the role of cytokines in the activat...
Saved in:
| Published in: | Immunology Vol. 120; no. 1; pp. 57 - 65 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Oxford, UK
Blackwell Publishing Ltd
01.01.2007
Blackwell Publishing Inc |
| Subjects: | |
| ISSN: | 0019-2805, 1365-2567 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Summary
γδ T‐cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper‐1 bias. We investigated the role of cytokines in the activation and induction of IFN‐γ secretion by bovine workshop cluster 1+ (WC1+) γδ T cells. The effects of culture with interleukin (IL)‐12, IL‐18, IL‐15 and IL‐2 were investigated; these cytokines are known to influence murine and human γδ T cells. We report that bovine WC1+γδ T cells are synergistically stimulated by IL‐12 and IL‐18 to secrete large quantities of IFN‐γ. Neonatal calves were shown to have significantly higher numbers of circulating WC1+γδ T cells than adult animals. In addition, the response of peripheral blood WC1+γδ T cells was significantly higher in neonatal calves compared with adult animals. However, in adult animals the response of lymph node WC1+γδ T cells to IL‐12/IL‐18 was more pronounced than that of peripheral blood WC1+γδ T cells. We hypothesize that the induction of IFN‐γ secretion from WC1+γδ T cells by IL‐12 and IL‐18 is likely to be an important element of the innate response to pathogens such as Mycobacterium bovis. The high numbers of WC1+γδ T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination. |
|---|---|
| AbstractList | γδ T‐cell receptor
+
T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper‐1 bias. We investigated the role of cytokines in the activation and induction of IFN‐γ secretion by bovine workshop cluster 1
+
(WC1
+
) γδ T cells. The effects of culture with interleukin (IL)‐12, IL‐18, IL‐15 and IL‐2 were investigated; these cytokines are known to influence murine and human γδ T cells. We report that bovine WC1
+
γδ T cells are synergistically stimulated by IL‐12 and IL‐18 to secrete large quantities of IFN‐γ. Neonatal calves were shown to have significantly higher numbers of circulating WC1
+
γδ T cells than adult animals. In addition, the response of peripheral blood WC1
+
γδ T cells was significantly higher in neonatal calves compared with adult animals. However, in adult animals the response of lymph node WC1
+
γδ T cells to IL‐12/IL‐18 was more pronounced than that of peripheral blood WC1
+
γδ T cells. We hypothesize that the induction of IFN‐γ secretion from WC1
+
γδ T cells by IL‐12 and IL‐18 is likely to be an important element of the innate response to pathogens such as
Mycobacterium bovis.
The high numbers of WC1
+
γδ T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination. γδ T-cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)-γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper-1 bias. We investigated the role of cytokines in the activation and induction of IFN-γ secretion by bovine workshop cluster 1+ (WC1+) γδ T cells. The effects of culture with interleukin (IL)-12, IL-18, IL-15 and IL-2 were investigated; these cytokines are known to influence murine and human γδ T cells. We report that bovine WC1+γδ T cells are synergistically stimulated by IL-12 and IL-18 to secrete large quantities of IFN-γ. Neonatal calves were shown to have significantly higher numbers of circulating WC1+γδ T cells than adult animals. In addition, the response of peripheral blood WC1+γδ T cells was significantly higher in neonatal calves compared with adult animals. However, in adult animals the response of lymph node WC1+γδ T cells to IL-12/IL-18 was more pronounced than that of peripheral blood WC1+γδ T cells. We hypothesize that the induction of IFN-γ secretion from WC1+γδ T cells by IL-12 and IL-18 is likely to be an important element of the innate response to pathogens such as Mycobacterium bovis. The high numbers of WC1+γδ T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination. Summary γδ T‐cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role in linking innate and adaptive immune responses and contribute to T helper‐1 bias. We investigated the role of cytokines in the activation and induction of IFN‐γ secretion by bovine workshop cluster 1+ (WC1+) γδ T cells. The effects of culture with interleukin (IL)‐12, IL‐18, IL‐15 and IL‐2 were investigated; these cytokines are known to influence murine and human γδ T cells. We report that bovine WC1+γδ T cells are synergistically stimulated by IL‐12 and IL‐18 to secrete large quantities of IFN‐γ. Neonatal calves were shown to have significantly higher numbers of circulating WC1+γδ T cells than adult animals. In addition, the response of peripheral blood WC1+γδ T cells was significantly higher in neonatal calves compared with adult animals. However, in adult animals the response of lymph node WC1+γδ T cells to IL‐12/IL‐18 was more pronounced than that of peripheral blood WC1+γδ T cells. We hypothesize that the induction of IFN‐γ secretion from WC1+γδ T cells by IL‐12 and IL‐18 is likely to be an important element of the innate response to pathogens such as Mycobacterium bovis. The high numbers of WC1+γδ T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination. |
| Author | Hope, Jayne C. Howard, Christopher J. Price, Sally J. Sopp, Paul |
| Author_xml | – sequence: 1 givenname: Sally J. surname: Price fullname: Price, Sally J. – sequence: 2 givenname: Paul surname: Sopp fullname: Sopp, Paul – sequence: 3 givenname: Christopher J. surname: Howard fullname: Howard, Christopher J. – sequence: 4 givenname: Jayne C. surname: Hope fullname: Hope, Jayne C. |
| BookMark | eNqNkU9u1DAUxi1URKeFO3hfJfhPYmcWIKGKQqVWbAaxtBz3ufHUE0d2ZjrdcQSOwB3KOeYQnASngwaxqzd-z5-_35Ped4KO-tADQpiSkubzdllSLuqC1UKWjBBRElZJWW5foNlBOEIzQui8YA2pj9FJSsvcclLXr9AxlYRXFatn6Oe3EO9SFwZs_DqNEDE92z3ufuHF7-8_DHiPIxgYxhDP8AJPDwnbGFbYaL-BhGE7REgJd-62wx42kPVgseszykIMfcbsHnOfOWkIfQI8BpxGt1p7PbrQ43s3dvv_HtZ3bjJQhnV_g6eqeY1eWu0TvPl7n6KvFx8X55-Lqy-fLs8_XBWGcy4LUxEBQoA1FfC5YbSVDQehyZxDY7WwraGCCkOtAVLplkEjuSTzpm5pJTTnp-j9njus2xXcGOjHqL0aolvp-KCCdup_pXedug0bxZioGykzoNkDTAwpRbAHLyVqSk0t1RSOmsJRU2rqKTW1_Tf7YDVufNpOnuT8cwDv9oB75-Hh2YPV5fX1VPE_BO-7xA |
| CitedBy_id | crossref_primary_10_1016_j_molimm_2010_12_001 crossref_primary_10_1155_2011_768542 crossref_primary_10_1016_j_dci_2008_06_014 crossref_primary_10_3390_pathogens10111512 crossref_primary_10_1016_j_cimid_2011_11_003 crossref_primary_10_1016_j_dci_2018_04_003 crossref_primary_10_1080_03079457_2019_1607966 crossref_primary_10_1016_j_jcpa_2014_08_001 crossref_primary_10_1002_cyto_a_20435 crossref_primary_10_1292_jvms_13_0534 crossref_primary_10_3389_fimmu_2024_1325024 crossref_primary_10_1111_tbed_12002 crossref_primary_10_1016_j_intimp_2015_04_008 crossref_primary_10_1016_j_vetimm_2010_07_006 crossref_primary_10_1016_j_psj_2024_104607 crossref_primary_10_1111_j_1365_3024_2010_01249_x crossref_primary_10_1016_j_vetimm_2014_02_010 crossref_primary_10_1016_j_vetimm_2011_03_013 crossref_primary_10_1371_journal_pone_0140046 crossref_primary_10_1016_j_molimm_2021_02_028 crossref_primary_10_1292_jvms_71_549 crossref_primary_10_1111_j_1365_2613_2009_00679_x crossref_primary_10_3390_v17081116 crossref_primary_10_1186_1743_422X_6_177 crossref_primary_10_1016_j_vetimm_2010_02_010 crossref_primary_10_1128_JVI_01545_10 crossref_primary_10_1177_0300985812463404 crossref_primary_10_1016_j_vetimm_2009_05_002 crossref_primary_10_1111_j_1865_1682_2009_01081_x crossref_primary_10_1016_j_dci_2014_07_007 crossref_primary_10_1016_j_vetimm_2013_02_016 crossref_primary_10_1111_j_1365_2567_2008_02889_x |
| Cites_doi | 10.4049/jimmunol.174.6.3386 10.1016/S0165-2427(98)00083-X 10.4049/jimmunol.166.9.5604 10.1002/eji.1830250331 10.1111/j.1365-2249.2005.02668.x 10.1002/eji.1830200415 10.1002/eji.1830261237 10.1016/S0952-7915(99)80055-7 10.1002/eji.1830160105 10.4049/jimmunol.149.10.3273 10.1016/S0165-2427(01)00334-8 10.4049/jimmunol.154.11.5832 10.1016/S0165-2427(02)00244-1 10.1016/0165-2427(96)05578-X 10.1016/0165-2427(91)90082-N 10.1128/IAI.70.3.1488-1500.2002 10.1046/j.1365-3083.1996.d01-332.x 10.1016/S0008-8749(02)00519-1 10.1189/jlb.69.2.271 10.1073/pnas.93.6.2272 10.1084/jem.178.3.971 10.1016/0008-8749(90)90047-U 10.1006/cimm.2001.1850 10.4049/jimmunol.159.9.4287 10.4049/jimmunol.160.9.4322 10.1016/S0165-2427(98)00184-6 10.1128/IAI.71.11.6411-6419.2003 10.1016/S0165-2427(02)00091-0 10.1002/eji.1830270321 10.1189/jlb.71.2.184 10.1016/j.vetimm.2004.04.007 10.1002/eji.1830190428 10.1016/S0165-2427(02)00200-3 10.1016/0165-2427(94)90019-1 10.1046/j.1365-3083.2002.01069.x 10.1051/vetres:2000118 10.1006/cimm.1994.1002 10.1146/annurev.immunol.18.1.975 10.1038/365053a0 10.1016/0165-2427(95)05543-6 10.1128/IAI.69.1.89-96.2001 10.1002/jlb.66.1.50 |
| ContentType | Journal Article |
| Copyright | 2006 The Authors Journal compilation © 2006 Blackwell Publishing Ltd 2006 |
| Copyright_xml | – notice: 2006 The Authors Journal compilation © 2006 Blackwell Publishing Ltd 2006 |
| DBID | AAYXX CITATION 5PM |
| DOI | 10.1111/j.1365-2567.2006.02477.x |
| DatabaseName | CrossRef PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | CrossRef |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1365-2567 |
| EndPage | 65 |
| ExternalDocumentID | PMC2265877 10_1111_j_1365_2567_2006_02477_x IMM2477 |
| Genre | article |
| GroupedDBID | --- -~X .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1OC 24P 29I 2WC 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 A8Z AAESR AAEVG AAHHS AAHQN AAIPD AAKAS AAMNL AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABPVW ABQWH ABXGK ACAHQ ACCFJ ACCZN ACGFO ACGFS ACGOF ACIWK ACMXC ACNCT ACPOU ACPRK ACSCC ACUHS ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZCM ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFRAH AFWVQ AFZJQ AHBTC AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB AOIJS ATUGU AZBYB AZVAB BAFTC BAWUL BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EAD EAP EAS EBB EBC EBD EBS EBX EJD EMB EMK EMOBN EPT ESX EX3 F00 F01 F04 F5P FD6 FIJ FUBAC G-S G.N GODZA GX1 H.X HF~ HGLYW HZI HZ~ H~9 IH2 IHE IPNFZ IX1 J0M J5H K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MVM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OBC OBS OHT OIG OK1 OVD P2P P2W P2X P2Z P4B P4D Q.N Q11 QB0 Q~Q R.K ROL RPM RX1 SUPJJ SV3 TEORI TR2 TUS UB1 UPT V8K W8V W99 WBKPD WH7 WHWMO WIH WIJ WIK WIN WOHZO WOQ WOW WQJ WRC WVDHM WXI WXSBR X7M XG1 Y6R YF5 YFH YOC YUY ZGI ZXP ZZTAW ~IA ~KM ~WT AAFWJ AAMMB AAYXX AEFGJ AEYWJ AGHNM AGXDD AGYGG AIDQK AIDYY CITATION O8X 5PM ESTFP |
| ID | FETCH-LOGICAL-c3337-c406e66efc4e39c21b783e6a093e8fa6fbc1616c1fce04ab2e87370985b146a33 |
| IEDL.DBID | WIN |
| ISSN | 0019-2805 |
| IngestDate | Tue Sep 30 16:59:01 EDT 2025 Tue Nov 18 21:49:39 EST 2025 Sat Nov 29 01:43:53 EST 2025 Wed Jan 22 16:25:07 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3337-c406e66efc4e39c21b783e6a093e8fa6fbc1616c1fce04ab2e87370985b146a33 |
| OpenAccessLink | http://doi.org/10.1111/j.1365-2567.2006.02477.x |
| PMID | 17034425 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2265877 crossref_primary_10_1111_j_1365_2567_2006_02477_x crossref_citationtrail_10_1111_j_1365_2567_2006_02477_x wiley_primary_10_1111_j_1365_2567_2006_02477_x_IMM2477 |
| PublicationCentury | 2000 |
| PublicationDate | January 2007 |
| PublicationDateYYYYMMDD | 2007-01-01 |
| PublicationDate_xml | – month: 01 year: 2007 text: January 2007 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK |
| PublicationTitle | Immunology |
| PublicationYear | 2007 |
| Publisher | Blackwell Publishing Ltd Blackwell Publishing Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Blackwell Publishing Inc |
| References | 2001; 166 2004; 100 1997; 159 1998; 160 1990; 128 2005; 174 1994; 153 2002; 55 2005; 139 1986; 16 1992; 149 1996; 93 1996; 52 1999; 66 1997; 27 2002; 218 1998; 63 2003; 71 1995; 154 2001; 69 1996; 53 1994; 40 1998; 66 1993; 365 2001; 81 2001; 212 1990; 20 2000; 18 1991; 27 1995; 25 2002; 89 2002; 87 2000; 31 1999; 11 2002; 70 2002; 71 2002; 90 1996; 26 1989; 19 1993; 178 1996; 44 e_1_2_7_5_2 e_1_2_7_4_2 e_1_2_7_3_2 e_1_2_7_2_2 e_1_2_7_9_2 e_1_2_7_8_2 e_1_2_7_7_2 e_1_2_7_6_2 e_1_2_7_18_2 e_1_2_7_17_2 e_1_2_7_15_2 e_1_2_7_14_2 e_1_2_7_40_2 e_1_2_7_13_2 e_1_2_7_41_2 e_1_2_7_42_2 e_1_2_7_11_2 e_1_2_7_43_2 e_1_2_7_10_2 e_1_2_7_27_2 e_1_2_7_28_2 e_1_2_7_29_2 Hanrahan CF (e_1_2_7_12_2) 1997; 159 Garcia VE (e_1_2_7_16_2) 1998; 160 e_1_2_7_25_2 e_1_2_7_24_2 e_1_2_7_30_2 e_1_2_7_23_2 e_1_2_7_31_2 e_1_2_7_22_2 e_1_2_7_32_2 e_1_2_7_21_2 e_1_2_7_33_2 e_1_2_7_20_2 e_1_2_7_34_2 e_1_2_7_35_2 Wijngaard PL (e_1_2_7_26_2) 1992; 149 e_1_2_7_36_2 e_1_2_7_37_2 e_1_2_7_38_2 e_1_2_7_39_2 Skeen MJ (e_1_2_7_19_2) 1995; 154 |
| References_xml | – volume: 11 start-page: 346 year: 1999 end-page: 51 article-title: IL‐12 and IFN‐γ in host defence against mycobacteria and salmonella in mice and men publication-title: Curr Opin Immunol – volume: 153 start-page: 9 year: 1994 end-page: 27 article-title: Functional and phenotypic characterization of WC1 γ/δ T cells isolated from Babesia bovis‐stimulated T cell lines publication-title: Cell Immunol – volume: 66 start-page: 99 year: 1998 end-page: 112 article-title: Production and characterization of monoclonal antibodies specific for bovine interleukin‐4 publication-title: Vet Immunol Immunopathol – volume: 27 start-page: 71 year: 1991 end-page: 6 article-title: Individual antigens of cattle. Differentiation antigens expressed predominantly on CD4 CD8 T lymphocytes (WC1, WC2) publication-title: Vet Immunol Immunopathol – volume: 149 start-page: 3273 year: 1992 end-page: 7 article-title: Molecular characterization of the WC1 antigen expressed specifically on bovine CD4 CD8 γδ T lymphocytes publication-title: J Immunol – volume: 218 start-page: 1 year: 2002 end-page: 6 article-title: Differentiation of human γ−δ T cells towards distinct memory phenotypes publication-title: Cell Immunol – volume: 44 start-page: 444 year: 1996 end-page: 52 article-title: Bovine γ/δ TCR T lymphocytes are stimulated to proliferate by autologous Theileria annulata‐infected cells in the presence of interleukin‐2 publication-title: Scand J Immunol – volume: 18 start-page: 975 year: 2000 end-page: 1026 article-title: γ/δ cells: a right time and a right place for a conserved third way of protection publication-title: Annu Rev Immunol – volume: 93 start-page: 2272 year: 1996 end-page: 9 article-title: γ/δand other unconventional T lymphocytes: what do they see and what do they do? publication-title: Proc Natl Acad Sci USA – volume: 31 start-page: 229 year: 2000 end-page: 39 article-title: Purification and characterization of bovine WC1 γδ T lymphocytes from peripheral blood publication-title: Vet Res – volume: 26 start-page: 3066 year: 1996 end-page: 73 article-title: Interleukin‐12 activates human γδ T cells: synergistic effect of tumour necrosis factor‐α publication-title: Eur J Immunol – volume: 66 start-page: 50 year: 1999 end-page: 8 article-title: Involvement of caveolae in the uptake of respiratory syncytial virus antigen by dendritic cells publication-title: J Leukoc Biol – volume: 365 start-page: 53 year: 1993 end-page: 6 article-title: Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen publication-title: Nature – volume: 212 start-page: 110 year: 2001 end-page: 7 article-title: Differentiation of resting human peripheral blood γδ T cells toward Th1‐ or Th2‐phenotype publication-title: Cell Immunol – volume: 40 start-page: 187 year: 1994 end-page: 99 article-title: Differential distribution of γδ T cell receptor lymphocyte subpopulations in blood and spleen of young and adult cattle publication-title: Vet Immunol Immunopathol – volume: 69 start-page: 271 year: 2001 end-page: 9 article-title: Differences in the induction of CD8 T cell responses by subpopulations of dendritic cells from afferent lymph are related to IL‐1 α secretion publication-title: J Leukoc Biol – volume: 53 start-page: 49 year: 1996 end-page: 60 article-title: T cell subsets in blood and lymphoid tissues obtained from fetal calves, maturing calves and adult bovine publication-title: Vet Immunol Immunopathol – volume: 55 start-page: 373 year: 2002 end-page: 81 article-title: Costimulatory molecule requirement for bovine WC1 γδ T cells' proliferative response to bacterial superantigens publication-title: Scand J Immunol – volume: 71 start-page: 6411 year: 2003 end-page: 9 article-title: Revaccination of neonatal calves with BCG reduces the level of protection against bovine tuberculosis induced by a single vaccination publication-title: Infect Immun – volume: 128 start-page: 542 year: 1990 end-page: 54 article-title: CD4 CD8 human T cells: phenotypic heterogeneity and activation requirements of freshly isolated ‘double‐negative’ T cells publication-title: Cell Immunol – volume: 16 start-page: 19 year: 1986 end-page: 25 article-title: Three distinct subpopulations of sheep T lymphocytes publication-title: Eur J Immunol – volume: 81 start-page: 85 year: 2001 end-page: 96 article-title: IFN‐γ and IL‐4 production by CD4, CD8 and WC1 γδ TCR ( ) T cells from cattle lymph nodes and blood publication-title: Vet Immunol Immunopathol – volume: 174 start-page: 3386 year: 2005 end-page: 93 article-title: γδ T cell function varies with the expressed WC1 coreceptor publication-title: J Immunol – volume: 19 start-page: 757 year: 1989 end-page: 64 article-title: depletion of BoT4 (CD4) and of non‐T4/T8 lymphocyte subsets in cattle with monoclonal antibodies publication-title: Eur J Immunol – volume: 178 start-page: 971 year: 1993 end-page: 84 article-title: Induction of murine peritoneal γ/δ T cells and their role in resistance to bacterial infection publication-title: J Exp Med – volume: 159 start-page: 4287 year: 1997 end-page: 94 article-title: Cellular requirements for the activation and proliferation of ruminant γδ T cells publication-title: J Immunol – volume: 89 start-page: 105 year: 2002 end-page: 14 article-title: The WC1 ( ) γδ T cell population in cattle: a possible role in resistance to intracellular infection publication-title: Vet Immunol Immunopathol – volume: 160 start-page: 4322 year: 1998 end-page: 9 article-title: IL‐15 enhances the response of human γδ T cells to non‐peptide [correction of non‐petide] microbial antigens publication-title: J Immunol – volume: 52 start-page: 275 year: 1996 end-page: 83 article-title: Analysis of monoclonal antibodies specific for the γδ TCR publication-title: Vet Immunol Immunopathol – volume: 90 start-page: 155 year: 2002 end-page: 68 article-title: Response of bovine γδ T cells to activation through CD3 publication-title: Vet Immunol Immunopathol – volume: 20 start-page: 809 year: 1990 end-page: 17 article-title: Identification of a bovine surface antigen uniquely expressed on CD4 CD8 T cell receptor γδ T lymphocytes publication-title: Eur J Immunol – volume: 25 start-page: 838 year: 1995 end-page: 46 article-title: Contribution of α/β and γ/δ T lymphocytes to immunity against bacillus Calmette Guerin: studies with T cell receptor‐deficient mutant mice publication-title: Eur J Immunol – volume: 63 start-page: 69 year: 1998 end-page: 72 article-title: Influence of IL‐12 on interferon‐γ production by bovine leucocyte subsets in response to bovine respiratory syncytial virus publication-title: Vet Immunol Immunopathol – volume: 71 start-page: 184 year: 2002 end-page: 94 article-title: NK‐like CD8 ( ) cells in immunologically naive neonatal calves that respond to dendritic cells infected with BCG publication-title: J Leukoc Biol – volume: 70 start-page: 1488 year: 2002 end-page: 500 article-title: Modulation of immune responses to in cattle depleted of WC1 ( ) γδ T cells publication-title: Infect Immunol – volume: 87 start-page: 251 year: 2002 end-page: 9 article-title: Activation of bovine peripheral blood γδ T cells for cell division and IFN‐γ production publication-title: Vet Immunol Immunopathol – volume: 166 start-page: 5604 year: 2001 end-page: 10 article-title: Antigen recognition and immunomodulation by γδ T cells in bovine tuberculosis publication-title: J Immunol – volume: 154 start-page: 5832 year: 1995 end-page: 41 article-title: Activation of γδ T cells for production of IFN‐γ is mediated by bacteria via macrophage‐derived cytokines IL‐1 and IL‐12 publication-title: J Immunol – volume: 69 start-page: 89 year: 2001 end-page: 96 article-title: responsiveness of γδ T cells from ‐infected cattle to mycobacterial antigens. predominant involvement of WC1 ( ) cells publication-title: Infect Immun – volume: 27 start-page: 717 year: 1997 end-page: 25 article-title: Growth arrest of γδ T cells induced by monoclonal antibody against WC1 correlates with activation of multiple tyrosine phosphatases and dephosphorylation of MAP kinase erk2 publication-title: Eur J Immunol – volume: 100 start-page: 187 year: 2004 end-page: 95 article-title: Interaction of antigen presenting cells with mycobacteria publication-title: Vet Immunol Immunopathol – volume: 139 start-page: 48 year: 2005 end-page: 56 article-title: Vaccination of neonatal calves with BCG induces protection against intranasal challenge with virulent publication-title: Clin Exp Immunol – ident: e_1_2_7_29_2 doi: 10.4049/jimmunol.174.6.3386 – ident: e_1_2_7_34_2 doi: 10.1016/S0165-2427(98)00083-X – ident: e_1_2_7_39_2 doi: 10.4049/jimmunol.166.9.5604 – ident: e_1_2_7_4_2 doi: 10.1002/eji.1830250331 – ident: e_1_2_7_35_2 doi: 10.1111/j.1365-2249.2005.02668.x – ident: e_1_2_7_24_2 doi: 10.1002/eji.1830200415 – ident: e_1_2_7_17_2 doi: 10.1002/eji.1830261237 – ident: e_1_2_7_43_2 doi: 10.1016/S0952-7915(99)80055-7 – ident: e_1_2_7_22_2 doi: 10.1002/eji.1830160105 – volume: 149 start-page: 3273 year: 1992 ident: e_1_2_7_26_2 article-title: Molecular characterization of the WC1 antigen expressed specifically on bovine CD4− CD8−γδ T lymphocytes publication-title: J Immunol doi: 10.4049/jimmunol.149.10.3273 – ident: e_1_2_7_28_2 doi: 10.1016/S0165-2427(01)00334-8 – volume: 154 start-page: 5832 year: 1995 ident: e_1_2_7_19_2 article-title: Activation of γδ T cells for production of IFN‐γ is mediated by bacteria via macrophage‐derived cytokines IL‐1 and IL‐12 publication-title: J Immunol doi: 10.4049/jimmunol.154.11.5832 – ident: e_1_2_7_9_2 doi: 10.1016/S0165-2427(02)00244-1 – ident: e_1_2_7_14_2 doi: 10.1016/0165-2427(96)05578-X – ident: e_1_2_7_23_2 doi: 10.1016/0165-2427(91)90082-N – ident: e_1_2_7_42_2 doi: 10.1128/IAI.70.3.1488-1500.2002 – ident: e_1_2_7_13_2 doi: 10.1046/j.1365-3083.1996.d01-332.x – ident: e_1_2_7_15_2 doi: 10.1016/S0008-8749(02)00519-1 – ident: e_1_2_7_30_2 doi: 10.1189/jlb.69.2.271 – ident: e_1_2_7_6_2 doi: 10.1073/pnas.93.6.2272 – ident: e_1_2_7_2_2 doi: 10.1084/jem.178.3.971 – ident: e_1_2_7_7_2 doi: 10.1016/0008-8749(90)90047-U – ident: e_1_2_7_18_2 doi: 10.1006/cimm.2001.1850 – volume: 159 start-page: 4287 year: 1997 ident: e_1_2_7_12_2 article-title: Cellular requirements for the activation and proliferation of ruminant γδ T cells publication-title: J Immunol doi: 10.4049/jimmunol.159.9.4287 – volume: 160 start-page: 4322 year: 1998 ident: e_1_2_7_16_2 article-title: IL‐15 enhances the response of human γδ T cells to non‐peptide [correction of non‐petide] microbial antigens publication-title: J Immunol doi: 10.4049/jimmunol.160.9.4322 – ident: e_1_2_7_33_2 doi: 10.1016/S0165-2427(98)00184-6 – ident: e_1_2_7_36_2 doi: 10.1128/IAI.71.11.6411-6419.2003 – ident: e_1_2_7_8_2 doi: 10.1016/S0165-2427(02)00091-0 – ident: e_1_2_7_25_2 doi: 10.1002/eji.1830270321 – ident: e_1_2_7_37_2 doi: 10.1189/jlb.71.2.184 – ident: e_1_2_7_38_2 doi: 10.1016/j.vetimm.2004.04.007 – ident: e_1_2_7_32_2 doi: 10.1002/eji.1830190428 – ident: e_1_2_7_41_2 doi: 10.1016/S0165-2427(02)00200-3 – ident: e_1_2_7_21_2 doi: 10.1016/0165-2427(94)90019-1 – ident: e_1_2_7_11_2 doi: 10.1046/j.1365-3083.2002.01069.x – ident: e_1_2_7_10_2 doi: 10.1051/vetres:2000118 – ident: e_1_2_7_27_2 doi: 10.1006/cimm.1994.1002 – ident: e_1_2_7_5_2 doi: 10.1146/annurev.immunol.18.1.975 – ident: e_1_2_7_3_2 doi: 10.1038/365053a0 – ident: e_1_2_7_20_2 doi: 10.1016/0165-2427(95)05543-6 – ident: e_1_2_7_40_2 doi: 10.1128/IAI.69.1.89-96.2001 – ident: e_1_2_7_31_2 doi: 10.1002/jlb.66.1.50 |
| SSID | ssj0013055 |
| Score | 1.9927094 |
| Snippet | Summary
γδ T‐cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a... γδ T‐cell receptor + T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)‐γ by γδ T cells may have a role... γδ T-cell receptor+ T lymphocytes are an important element of the innate immune system. Early production of interferon (IFN)-γ by γδ T cells may have a role in... |
| SourceID | pubmedcentral crossref wiley |
| SourceType | Open Access Repository Enrichment Source Index Database Publisher |
| StartPage | 57 |
| SubjectTerms | bovine interferon‐γ interleukin‐12 neonatal Original workshop cluster 1+γδ T cells |
| Title | Workshop cluster 1+γδ T‐cell receptor+ T cells from calves express high levels of interferon‐γ in response to stimulation with interleukin‐12 and ‐18 |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2567.2006.02477.x https://pubmed.ncbi.nlm.nih.gov/PMC2265877 |
| Volume | 120 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1365-2567 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0013055 issn: 0019-2805 databaseCode: DRFUL dateStart: 19960101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Open Access customDbUrl: eissn: 1365-2567 dateEnd: 20241209 omitProxy: false ssIdentifier: ssj0013055 issn: 0019-2805 databaseCode: WIN dateStart: 19960101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELZQ-RGXAoWqW6CaA7cqKImT2DkiYEUldoXQVvQW2c5YXbEkq81uVW59hD4C71CeYx-CJ8HjhKVBHCrEKc7POIrmJ-OZ8TeMvdBKq6RM4gBVbIJEWKdSXGNQOtlCk1uOpfLNJsR4LE9O8g9d_RPthWnxITYBN9IMb69JwZVu-kruK7TSTHQ5hTgR4iX5k1HidfTT0fh3QiFMu2YGeRDLMO0X9fx1ot6f6s-KyeuerP8VDR_8z494yLY7hxRetRL0iN3CaofdbVtUft1h90Zd8v0x-0aB9ea0noOZrQhfAaLD9dX6O0x-XFxSAgCc9cS5W8QfwgToQgO0ewWcGJxhA3jui26BEJJhRsVKDdQWCLBiYXFRV26a9ZU7d_P4wl2EZQ3OBH3pWowBBY3b52e4-jwlgigGVZVAI_mEHQ_fTl6_C7oGD4HhnIvAOG8CswytSZDnJo60kBwzFeYcpVWZ1cY5pJmJrMEwUTpGKbgIc5lqZ-AV57tsq6or3GNgnaOWh1qiOyQ8xtxqKzBVUqPSWMoBE7-YWZgO_ZyacMyKa6sgx4qCWEG9ObPCs6I4H7BoQzlvEUBuQCN68rIhJDDv_p1qeupBvZ0bnEohBizz8nLjVxVHoxGN9v-V8Cm738arKaz0jG0tFyt8zu6Ys-W0WRyw228-Do_fH3ht-gm9AiXg |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtNAEF6hFCgXfgqo4XcO3Coj22t710dUiFqRRAilUm_W7npWjQh2FCdVufEIPELfoX2OPESfhB3bhBpxqBAnr39mLWt-PDsz-w1jb7TSKsqj0EMVGi8S1qkU1-jlTrbQpJZjrupmE2I8lsfH6ae2HRDthWnwITYBN9KM2l6TglNAuqvldYlWnIg2qRBGQrx1DuVW5KQq7rGt958HR8PfSQU_bhsapF4o_bhb2PPXuTp_qz-rJq97s_XvaPDgv37IQ3a_9UrhXSNGj9gtLHbYnaZP5bcddnfUZuAfs3OKrlcn5RzMbEUgCxDsrS_WlzC5-v6DsgDgTCjO3Up-DyZAFyqgLSzgZOEUK8CzuvIWCCYZZlSxVEFpgVArFhYXZeGmWV-4czdPXb2LsCzB2aGvbZ8xoMhx8_wMV1-mRBCEoIocaCSfsKPBh8n-gdd2efAM51x4xrkUmCRoTYQ8NWGgheSYKD_lKK1KrDbOK01MYA36kdIhSsGFn8pYOyuvOH_KekVZ4C4D67y11NcS3SHiIaZWW4GxkhqVxlz2mfjFzcy0EOjUiWOWXVsKOVZkxApq0JlkNSuysz4LNpTzBgbkBjSiIzAbQkL07t4ppic1srfzhWMpRJ8ltcDc-FXZ4WhEo2f_SviabR9MRsNseDj--JzdawLYFGd6wXrLxQpfstvmdDmtFq9apfoJa2gpjA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELZQCxUXfgqI5XcO3KqgJE5i54goKyq6qwptpd4i2xmrqy7JarNblRuPwCPwDuU59iF4EjxOWBrEoUKc4vyMo2h-Mp4Zf8PYK620SsokDlDFJkiEdSrFNQalky00ueVYKt9sQozH8uQkP-raAdFemBYfYhNwI83w9poUHOel7Wu5L9FKM9ElFeJEiNfOodxO0jxzWrq9_3F4fPg7qRCmXUODPIhlmPYLe_46V-9v9WfV5FVv1v-Ohnf_64fcY3c6rxTetGJ0n93AapfdavtUft5lO6MuA_-AfaPoenNaz8HMVgSyANHe-nL9HSY_vnylLAA4E4pzt5LfgwnQhQZoCws4WTjHBvDCV94CwSTDjCqWGqgtEGrFwuKirtw060t37ubx1bsIyxqcHfrU9RkDihy3z89wdTYlgigGVZVAI_mQHQ_fTd6-D7ouD4HhnIvAOJcCswytSZDnJo60kBwzFeYcpVWZ1cZ5pZmJrMEwUTpGKbgIc5lqZ-UV54_YVlVX-JiBdd5aHmqJ7pDwGHOrrcBUSY1KYykHTPziZmE6CHTqxDErriyFHCsKYgU16MwKz4riYsCiDeW8hQG5Bo3oCcyGkBC9-3eq6alH9na-cCqFGLDMC8y1X1UcjEY0evKvhC_ZztH-sDg8GH94ym638WsKMz1jW8vFCp-zm-Z8OW0WLzqd-gm7aykH |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Workshop+cluster+1%2B%CE%B3%CE%B4+T%E2%80%90cell+receptor%2B+T+cells+from+calves+express+high+levels+of+interferon%E2%80%90%CE%B3+in+response+to+stimulation+with+interleukin%E2%80%9012+and+%E2%80%9018&rft.jtitle=Immunology&rft.au=Price%2C+Sally+J.&rft.au=Sopp%2C+Paul&rft.au=Howard%2C+Christopher+J.&rft.au=Hope%2C+Jayne+C.&rft.date=2007-01-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0019-2805&rft.eissn=1365-2567&rft.volume=120&rft.issue=1&rft.spage=57&rft.epage=65&rft_id=info:doi/10.1111%2Fj.1365-2567.2006.02477.x&rft.externalDBID=10.1111%252Fj.1365-2567.2006.02477.x&rft.externalDocID=IMM2477 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0019-2805&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0019-2805&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0019-2805&client=summon |